Mcts1 MGI Mouse Gene Detail - MGI:1916245 - malignant T cell amplified sequence 1

Symbol

Mcts1
Name

malignant T cell amplified sequence 1
Synonyms

1500019M23Rik, MCT-1

Feature Type

protein coding gene
IDs

MGI:1916245
NCBI Gene: 68995
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

ChrX:37689455-37702303 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 22.88 cM, cytoband A2
Mapping Data

2 experiments

SNPs within 2kb

23 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916245	protein coding gene	ChrX:37653682-37702401 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035667	protein coding gene	ChrX:33572409-33588448 (+)
A/J	MGP_AJ_G0035652	protein coding gene	ChrX:33622523-33640840 (+)
AKR/J	MGP_AKRJ_G0035569	protein coding gene	ChrX:34418101-34433010 (+)
BALB/cJ	MGP_BALBcJ_G0035636	protein coding gene	ChrX:33328427-33341867 (+)
C3H/HeJ	MGP_C3HHeJ_G0035340	protein coding gene	ChrX:33935747-33951674 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036167	protein coding gene	ChrX:34341767-34360493 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033019	protein coding gene	ChrX:32034495-32045225 (+)
CAST/EiJ	MGP_CASTEiJ_G0034631	protein coding gene	ChrX:21932185-21950396 (+)
CBA/J	MGP_CBAJ_G0035314	protein coding gene	ChrX:35209292-35225286 (+)
DBA/2J	MGP_DBA2J_G0035468	protein coding gene	ChrX:33462112-33474336 (+)
FVB/NJ	MGP_FVBNJ_G0035417	protein coding gene	ChrX:33211205-33224047 (+)
LP/J	MGP_LPJ_G0035556	protein coding gene	ChrX:33972175-33984791 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035455	protein coding gene	ChrX:35542508-35558965 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036183	protein coding gene	ChrX:33617077-33633547 (+)
PWK/PhJ	MGP_PWKPhJ_G0034332	protein coding gene	ChrX:21514631-21527622 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034177	protein coding gene	ChrX:22477792-22492406 (+)
WSB/EiJ	MGP_WSBEiJ_G0034777	protein coding gene	ChrX:33297936-33313837 (+)

Human Ortholog

MCTS1, MCTS1 re-initiation and release factor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MCTS1, MCTS1 re-initiation and release factor
Synonyms

MCT1, MCT-1
Links

HGNC:23357

NCBI Gene ID: 28985

neXtProt AC: NX_Q9ULC4

UniProt: Q9ULC4
Chr Location

Xq24; chrX:120603889-120621159 (+) GRCh38.p7

Alliance of Genome Resources

Mcts1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MCTS1
Protein SuperFamily

Tma_RNA-bind_prd
Gene Tree

Mcts1

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Endonuclease-mediated

1
Gene trapped

20
Targeted

2
Incidental Mutations

APF
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

15
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

672
cDNA Data

63
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mcts1

ZFIN mcts1

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Mcts1 interacts with 26 markers (Mir136, Mir144, Mir154, ...) View All

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All Sequences

49
RefSeq

15
UniProt

1
CCDS

CCDS30094.1

Ensembl

ENSMUSG00000000355 (Evidence)
NCBI Gene

68995

			Length	Strain/Species	Flank
genomic	ENSMUSG00000000355	Ensembl Gene Model \| MGI Sequence Detail	12849	C57BL/6J	± kb
transcript	ENSMUST00000000365	Ensembl \| MGI Sequence Detail	783	Not Applicable
polypeptide	ENSMUSP00000000365	Ensembl \| MGI Sequence Detail	181	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000010257 malignant T cell-amplified sequence 1

(term hierarchy)
InterPro Domains

IPR016437 MCT-1/Tma20

IPR041366 Pre-PUA domain

IPR002478 PUA domain

IPR036974 PUA domain superfamily

IPR015947 PUA-like superfamily

IPR004521 Uncharacterised domain CHP00451

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All nucleic 63

cDNA 63

Microarray probesets 3

Summaries

All 36

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:237626 Kwon SH, et al., Adaptor Protein CD2AP and L-type Lectin LMAN2 Regulate Exosome Cargo Protein Trafficking through the Golgi Complex. J Biol Chem. 2016 Dec 02;291(49):25462-25475

TSS for Mcts1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr160788	ChrX:37689326-37689337 (+)	-123 bp
Tssr160789	ChrX:37689467-37689474 (+)	16 bp
Tssr160790	ChrX:37689503-37689568 (+)	81 bp
Tssr160791	ChrX:37689735-37689765 (+)	295 bp
Tssr160792	ChrX:37690086-37690151 (+)	664 bp
Tssr160793	ChrX:37696195-37696198 (+)	6,742 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/19/2021 MGI 6.17