Mcts1 Gene Detail

Summary

• Symbol
  Mcts1
• Name
  malignant T cell amplified sequence 1
• Synonyms
  1500019M23Rik, MCT-1

• Feature Type
  protein coding gene
• IDs
  MGI:1916245
  NCBI Gene: 68995
• Alliance
  gene page

Location & Maps

• Sequence Map
  ChrX:38600578-38613426 bp, + strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    12849 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome X, 22.88 cM, cytoband A2
• Mapping Data
  2 experiments

Homology

• Human Ortholog
  MCTS1, MCTS1, re-initiation and release factor

• Vertebrate Orthologs
  10

• Human Ortholog
  MCTS1, MCTS1, re-initiation and release factor
  Orthology source: HomoloGene, HGNC
• Synonyms
  MCT1, MCT-1
• Links
  HGNC:23357

  NCBI Gene ID: 28985

  neXtProt AC: NX_Q9ULC4

  UniProt: Q9ULC4

  
  
• Chr Location
  Xq24; chrX:120603889-120621159 (+)  GRCh38.p7

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• HomoloGene
  Vertebrate Homology Class 5803
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: MCTS1
• Protein SuperFamily
  translation machinery-associated RNA binding protein
• Gene Tree
  Mcts1
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  8 phenotype references
  

• All Mutations and Alleles
  24
• Endonuclease-mediated
  1
• Gene trapped
  21
• Targeted
  2
• Incidental Mutations
  APF
• Find Mice (IMSR)
  14 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  19
• GO References
  4

• External Resources
  FuncBase

Expression

• cDNA Data
  62
• Literature Summary
  3

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase mcts1
  ZFIN mcts1

Interactions

• Mcts1 interacts with 26 markers (Mir136, Mir144, Mir154, ...) View All

Sequences &
Gene Models

• All Sequences
  34
• RefSeq
  11
• UniProt
  1
• CCDS
  CCDS30094.1
• UniGene
  262453

• VEGA
  OTTMUSG00000017243 (Evidence)
• Ensembl
  ENSMUSG00000000355 (Evidence)
• NCBI Gene
  68995

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000017243	VEGA Gene Model | MGI Sequence Detail	12849	C57BL/6J
transcript	OTTMUST00000041729	VEGA | MGI Sequence Detail	783	Not Applicable
polypeptide	OTTMUSP00000018754	VEGA | MGI Sequence Detail	181	Not Applicable

Polymorphisms

• SNPs within 2kb
  27 from dbSNP Build 142

Protein
Information

• UniProt
  1 Sequence
• Protein Ontology
  PR:000010257 malignant T cell-amplified sequence 1
  (term hierarchy)
• InterPro Domains
  IPR016437 MCT-1/Tma20
  IPR002478 PUA domain
  IPR036974 PUA domain superfamily
  IPR015947 PUA-like superfamily
  IPR004521 Uncharacterised domain CHP00451

Molecular
Reagents

• All nucleic 62

  cDNA 62

  
  

  Microarray probesets 3

References

• Summaries
  All 35

  Developmental Gene Expression 3

  Gene Ontology 4

  Phenotypes 8
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:237626 Kwon SH, et al., Adaptor Protein CD2AP and L-type Lectin LMAN2 Regulate Exosome Cargo Protein Trafficking through the Golgi Complex. J Biol Chem. 2016 Dec 02;291(49):25462-25475