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Prpf31 Gene Detail
Summary
  • Symbol
    Prpf31
  • Name
    pre-mRNA processing factor 31
  • Synonyms
    1500019O16Rik, 2810404O06Rik, PRP31, RP11
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916238
    NCBI Gene: 68988
  • Gene Overview
    MyGene.info: PRPF31
  • Alliance
Location & Maps
more
  • Genetic Map
    Chromosome 7, 2.09 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PRPF31, pre-mRNA processing factor 31
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PRPF31, pre-mRNA processing factor 31
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NY-BR-99, PRP31, RP11, SNRNP61
  • Links
    NCBI Gene ID: 26121
    neXtProt AC: NX_Q8WWY3
    UniProt: Q8WWY3

  • Chr Location
    19q13.42; chr19:54115410-54131719 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Prpf31 mouse models; 1 with human PRPF31 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 4 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-in allele die prior to E10. Mice homozygous for a knock-out allele are not produced.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000023399 VEGA Gene Model | MGI Sequence Detail 12502 C57BL/6J ±  kb
    transcript OTTMUST00000056825 VEGA | MGI Sequence Detail 3144 Not Applicable  
    polypeptide OTTMUSP00000027355 VEGA | MGI Sequence Detail 499 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      32 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 117
      cDNA 117

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1917376, MGI:2142262
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 1
      Diseases 2
      Gene Ontology 4
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory