About   Help   FAQ
Prpf31 Gene Detail
Summary
  • Symbol
    Prpf31
  • Name
    pre-mRNA processing factor 31
  • Synonyms
    1500019O16Rik, 2810404O06Rik, PRP31, RP11
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916238
    NCBI Gene: 68988
  • Gene Overview
    MyGene.info: PRPF31
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:3629985-3642485 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 2.09 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    32 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916238
protein coding gene Chr7:3629985-3642486 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031524
protein coding gene Chr7:555437-567936 (+)
A/J MGP_AJ_G0031499
protein coding gene Chr7:493913-506414 (+)
AKR/J MGP_AKRJ_G0031427
protein coding gene Chr7:512067-524568 (+)
BALB/cJ MGP_BALBcJ_G0031507
protein coding gene Chr7:506680-519179 (+)
C3H/HeJ MGP_C3HHeJ_G0031227
protein coding gene Chr7:512937-525436 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031967
protein coding gene Chr7:526431-538932 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029094
protein coding gene Chr7:396959-409960 (+)
CAST/EiJ MGP_CASTEiJ_G0030596
protein coding gene Chr7:514004-526476 (+)
CBA/J MGP_CBAJ_G0031187
protein coding gene Chr7:650621-663120 (+)
DBA/2J MGP_DBA2J_G0031344
protein coding gene Chr7:491456-504160 (+)
FVB/NJ MGP_FVBNJ_G0031296
protein coding gene Chr7:486325-498824 (+)
LP/J MGP_LPJ_G0031429
protein coding gene Chr7:562188-574687 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031335
protein coding gene Chr7:557386-569887 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032001
protein coding gene Chr7:500301-512798 (+)
PWK/PhJ MGP_PWKPhJ_G0030323
protein coding gene Chr7:639120-651616 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030147
protein coding gene Chr7:569289-581615 (+)
WSB/EiJ MGP_WSBEiJ_G0030690
protein coding gene Chr7:503574-516073 (+)



Homology
more
  • Human Ortholog
    PRPF31, pre-mRNA processing factor 31
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PRPF31, pre-mRNA processing factor 31
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NY-BR-99, PRP31, RP11, SNRNP61
  • Links
    NCBI Gene ID: 26121
    neXtProt AC: NX_Q8WWY3
    UniProt: Q8WWY3

  • Chr Location
    19q13.42; chr19:54115410-54131719 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Prpf31 mouse models; 1 with human PRPF31 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 4 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-in allele die prior to E10. Mice homozygous for a knock-out allele are not produced.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68988 NCBI Gene Model | MGI Sequence Detail 12501 C57BL/6J ±  kb
    transcript NM_027328 RefSeq | MGI Sequence Detail 3143 C57BL/6  
    polypeptide Q8CCF0 UniProt | EBI | MGI Sequence Detail 499 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 117
      cDNA 117

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1917376, MGI:2142262
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 1
      Diseases 2
      Gene Ontology 5
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory