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Prpf31
Gene Detail
Symbol

Name
ID
Prpf31
PRP31 pre-mRNA processing factor 31 homolog (yeast)
MGI:1916238
Synonyms
1500019O16Rik, 2810404O06Rik, PRP31, RP11
Feature Type
protein coding gene
Genetic Map
Chromosome 7
2.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:3629985-3642486 bp, + strand
From VEGA annotation of GRCm38

  12502 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5980  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PRPF31
Gene Tree: Prpf31

Human
homologs
PRPF31, pre-mRNA processing factor 31
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 26121
neXtProt AC: NX_Q8WWY3

Human Synonyms: NY-BR-99, PRP31, RP11, SNRNP61

Human Chr (Location): 19q13.42; chr19:54115376-54131719 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PRPF31

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(11) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-in allele die prior to E10. Mice homozygous for a knock-out allele are not produced.
 
Human Diseases Modeled in Mice Using Prpf31 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Prpf31 interacts with 189 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process mRNA processing, mRNA splicing, via spliceosome, ...
Component Cajal body, MLL1 complex, ...
Function poly(A) RNA binding, ribonucleoprotein complex binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (1)    Tissues (1)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
cDNA source data(116)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase prpf31 ; ZFIN prpf31    NEW 
Molecular
reagents
All nucleic(116) cDNA(116)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000023399 (Evidence)
Ensembl Gene Model ENSMUSG00000008373 (Evidence)
Entrez Gene 68988 (Evidence)
UniGene 246863
DFCI TC1707843, TC1585295, TC1592392, TC1574913
DoTS DT.488942, DT.101286304, DT.97401292, DT.489982, DT.97414045
NIA Mouse Gene Index U007605
Consensus CDS Project CCDS39729.1, CCDS51965.1
International Mouse Phenotyping Consortium Status Prpf31
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023399 VEGA Gene Model | MGI Sequence Detail 12502 C57BL/6J ±  kb
transcript OTTMUST00000056825 VEGA | MGI Sequence Detail 3144 Not Applicable 
polypeptide OTTMUSP00000027355 VEGA | MGI Sequence Detail 499 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(32 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002687 Nop domain
InterPro IPR012976 NOSIC
InterPro IPR019175 Prp31 C-terminal
InterPro IPR027105 U4/U6 small nuclear ribonucleoprotein Prp31
Protein Ontology PR:000013279 U4/U6 small nuclear ribonucleoprotein Prp31
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:216059 Farkas MH, et al., Mutations in pre-mRNA processing factors 3, 8, and 31 cause dysfunction of the retinal pigment epithelium. Am J Pathol. 2014 Oct;184(10):2641-52
All references(35)
Disease annotation references (2)
Other
accession IDs
MGI:1917376, MGI:2142262

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory