Prpf31
Gene Detail

Symbol Name ID

Prpf31 PRP31 pre-mRNA processing factor 31 homolog (yeast) MGI:1916238

Synonyms

1500019O16Rik, 2810404O06Rik, PRP31, RP11

Feature Type

protein coding gene

Genetic Map

Chromosome 7

2.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:3629985-3642486 bp, + strand From VEGA annotation of GRCm38   12502 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:5980  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Prpf31

Human homologs

Human Homolog		PRPF31, PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae)
NCBI Gene ID		26121
neXtProt AC		NX_Q8WWY3
Human Synonyms		NY-BR-99, PRP31, RP11
Human Chr (Location)		19q13.42; chr19:54618790-54635150 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PRPF31

Alleles and phenotypes

All alleles(17) : Targeted(6) Gene trapped(11)
 

Mice homozygous for a knock-in allele die prior to E10. Mice homozygous for a knock-out allele are not produced.

 
Human Diseases Modeled Using Mouse Prpf31 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	assembly of spliceosomal tri-snRNP, mRNA processing, ...
Component	Cajal body, MLL1 complex, ...
Function	ribonucleoprotein complex binding, RNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (1)    Tissues (1)    Images (1)
Theiler Stages: 23

Assay Type	Results
RNA in situ	1

cDNA source data(116)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(116) cDNA(116)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000023399 (Evidence)
Ensembl Gene Model	ENSMUSG00000008373 (Evidence)
Entrez Gene	68988 (Evidence)
UniGene	246863
DFCI	TC1574913, TC1585295, TC1592392, TC1707843
DoTS	DT.101286304, DT.488942, DT.489982, DT.97401292, DT.97414045
NIA Mouse Gene Index	U007605
Consensus CDS Project	CCDS39729.1, CCDS51965.1
International Mouse Knockout Project Status	Prpf31

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023399	VEGA Gene Model | MGI Sequence Detail	12502	C57BL/6J
transcript	OTTMUST00000056825	VEGA | MGI Sequence Detail	3144	Not Applicable
polypeptide	OTTMUSP00000027355	VEGA | MGI Sequence Detail	499	Not Applicable

All sequences(52) RefSeq(4) UniProt(1)

Polymorphisms

SNPs(23 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR012976	NOSIC
InterPro	IPR002687	Pre-mRNA processing ribonucleoprotein, snoRNA-binding domain
InterPro	IPR019175	Prp31 C-terminal
Protein Ontology	PR:000013279	U4/U6 small nuclear ribonucleoprotein Prp31

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(34)

Other accession IDs

MGI:1917376, MGI:2142262