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Srrm4 Gene Detail
Summary
  • Symbol
    Srrm4
  • Name
    serine/arginine repetitive matrix 4
  • Synonyms
    1500001A10Rik, B230202K19Rik, bv, flopsy, fp, mKIAA1853, nSR100
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916205
    NCBI Gene: 68955
Location & Maps
more
  • Sequence Map
    Chr5:116439275-116591817 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      152543 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 56.45 cM, cytoband F
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    SRRM4, serine/arginine repetitive matrix 4
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SRRM4, serine/arginine repetitive matrix 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    KIAA1853, MU-MB-2.76, nSR100
  • Links
    NCBI Gene ID: 84530
    neXtProt AC: NX_A7MD48

  • Chr Location
    12q24.23; chr12:118981486-119163053 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 3 alleles in 3 genetic backgrounds
    1 images
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Chemically induced (other)
    1
  • Gene trapped
    9
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    5
  • Transgenic
    1
  • Genomic Mutations
    2 involving Srrm4
  • Incidental Mutations
Mutants show waltzing behavior, inner ear abnormalities, and deafness.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014692 VEGA Gene Model | MGI Sequence Detail 152543 C57BL/6J ±  kb
transcript OTTMUST00000034842 VEGA | MGI Sequence Detail 7472 Not Applicable  
polypeptide OTTMUSP00000015582 VEGA | MGI Sequence Detail 608 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1114 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000030470 serine/arginine repetitive matrix protein 4
  • InterPro Domains
    IPR029360 Serine/arginine repetitive matrix protein, C-terminal
Molecular
Reagents
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  • All nucleic 11
    cDNA 8
    Primer pair 1
    Other 2

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-1687, MGD-MRK-9868, MGI:1925852, MGI:88220
References
more
  • Summaries
    All 53
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 35
  • Earliest
    J:28901 Gluecksohn Waelsch S, Research News. Mouse News Lett. 1969;41:16
  • Latest
    J:221584 Quesnel-Vallieres M, et al., Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development. Genes Dev. 2015 Apr 1;29(7):746-59

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory