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Chmp2b
Gene Detail
Symbol

Name
ID
Chmp2b
charged multivesicular body protein 2B
MGI:1916192
Synonyms
1190006E07Rik, chromatin modifying protein 2B
Feature Type
protein coding gene
Genetic Map
Chromosome 16
37.26 cM, cytoband C1.3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:65539133-65562697 bp, - strand
From NCBI annotation of GRCm38

  23565 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8534  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CHMP2B
Protein SuperFamily: ESCRT-3 complex, Chmp1/Chmp2/Chmp3 subunits
Gene Tree: Chmp2b

Human
homologs
CHMP2B, charged multivesicular body protein 2B
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 25978
neXtProt AC: NX_Q9UQN3

Human Synonyms: ALS17, CHMP2.5, DMT1, VPS2-2, VPS2B

Human Chr (Location): 3p11.2; chr3:87227263-87255548 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human CHMP2B

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(3) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Chmp2b interacts with 166 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process cell separation after cytokinesis, cognition, ...
Component cytoplasm, cytosol, ...
Function protein domain specific binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (106)    Tissues (32)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 20
RNA in situ 58
Western blot 28
cDNA source data(66)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase chmp2b    NEW 
Molecular
reagents
All nucleic(66) cDNA(66)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000004843 (Evidence)
Entrez Gene 68942 (Evidence)
UniGene 432944
DFCI TC1575081
DoTS DT.101405429
NIA Mouse Gene Index U037179
Consensus CDS Project CCDS28269.1
International Mouse Phenotyping Consortium Status Chmp2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 68942 NCBI Gene Model | MGI Sequence Detail 23565 C57BL/6J ±  kb
transcript NM_026879 RefSeq | MGI Sequence Detail 1838 C57BL/6 
polypeptide Q8BJF9 UniProt | EBI | MGI Sequence Detail 213 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(135 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005024 Snf7
Protein Ontology PR:000005435 charged multivesicular body protein 2b
Graphical View of Protein Domain Structure
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:219860 Chassefeyre R, et al., Regulation of postsynaptic function by the dementia-related ESCRT-III subunit CHMP2B. J Neurosci. 2015 Feb 18;35(7):3155-73
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory