Smim11 MGI Mouse Gene Detail - MGI:1916186 - small integral membrane protein 11

Symbol

Smim11
Name

small integral membrane protein 11
Synonyms

1190017O12Rik, Fam165b

Feature Type

protein coding gene
IDs

MGI:1916186
NCBI Gene: 68936
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr16:92098174-92109929 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 53.55 cM
Mapping Data

1 experiment

SNPs within 2kb

43 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916186	protein coding gene	Chr16:92098131-92109929 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023054	protein coding gene	Chr16:93382617-93395343 (+)
A/J	MGP_AJ_G0023022	protein coding gene	Chr16:89004856-89016853 (+)
AKR/J	MGP_AKRJ_G0022992	protein coding gene	Chr16:91716734-91728492 (+)
BALB/cJ	MGP_BALBcJ_G0023024	protein coding gene	Chr16:89533376-89545852 (+)
C3H/HeJ	MGP_C3HHeJ_G0022785	protein coding gene	Chr16:92258179-92269938 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023471	protein coding gene	Chr16:96354711-96366466 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020973	protein coding gene	Chr16:86691448-86703021 (+)
CAST/EiJ	MGP_CASTEiJ_G0022304	protein coding gene	Chr16:92853250-92864858 (+)
CBA/J	MGP_CBAJ_G0022754	protein coding gene	Chr16:100505170-100516934 (+)
DBA/2J	MGP_DBA2J_G0022888	protein coding gene	Chr16:88907222-88921747 (+)
FVB/NJ	MGP_FVBNJ_G0022862	protein coding gene	Chr16:88034550-88047368 (+)
LP/J	MGP_LPJ_G0022958	protein coding gene	Chr16:93068057-93085269 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022883	protein coding gene	Chr16:105007473-105020702 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023489	protein coding gene	Chr16:92224572-92236358 (+)
PWK/PhJ	MGP_PWKPhJ_G0022049	protein coding gene	Chr16:89093977-89105801 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021879	protein coding gene	Chr16:91788091-91799768 (+)
WSB/EiJ	MGP_WSBEiJ_G0022356	protein coding gene	Chr16:92461462-92478630 (+)

Human Ortholog

SMIM11, small integral membrane protein 11

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SMIM11, small integral membrane protein 11
Synonyms

C21orf51, FAM165B, SMIM11A, SMIM11B
Links

HGNC:1293

NCBI Gene ID: 54065

neXtProt AC: NX_P58511

UniProt: P58511
Chr Location

21q22.11; chr21:34375480-34416961 (+) GRCh38

MGI Vertebrate Homology

Smim11 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SMIM11
Gene Tree

Smim11

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References

4 with disease annotations

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Phenotype Summary

75 phenotype references

All Mutations and Alleles

26
Gene trapped

11
Spontaneous

1
Targeted

13
Genomic Mutations

9 involving Smim11
Find Mice (IMSR)

9 strains or lines available

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All GO Annotations

1
GO References

1

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

913
Tissues

161
cDNA Data

6
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase smim11

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All Sequences

37
RefSeq

4
UniProt

1
CCDS

CCDS37404.1

Ensembl

ENSMUSG00000051989 (Evidence)
NCBI Gene

68936

			Length	Strain/Species	Flank
genomic	ENSMUSG00000051989	Ensembl Gene Model \| MGI Sequence Detail	11756	C57BL/6J	± kb
transcript	ENSMUST00000118064	Ensembl \| MGI Sequence Detail	782	Not Applicable
polypeptide	ENSMUSP00000113086	Ensembl \| MGI Sequence Detail	55	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000031558 small integral membrane protein 11

(term hierarchy)
InterPro Domains

IPR042125 Small integral membrane protein 11

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All nucleic 8

cDNA 6

Primer pair 2

Microarray probesets 3

Summaries

All 100

Developmental Gene Expression 4

Diseases 4

Gene Ontology 1

Phenotypes 75
Earliest

J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
Latest

J:335294 Redhead Y, et al., Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes. Development. 2023 Apr 15;150(8):dev201077

TSS for Smim11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr139473	Chr16:92098154-92098211 (+)	9 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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