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Ptcd2 Gene Detail
Summary
  • Symbol
    Ptcd2
  • Name
    pentatricopeptide repeat domain 2
  • Synonyms
    1190005P08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916177
    NCBI Gene: 68927
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:99319649-99344678 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 52.76 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    181 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916177
protein coding gene Chr13:99319647-99344705 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020874
protein coding gene Chr13:101102620-101127280 (-)
A/J MGP_AJ_G0020828
protein coding gene Chr13:97226075-97250780 (-)
AKR/J MGP_AKRJ_G0020802
protein coding gene Chr13:100198495-100224834 (-)
BALB/cJ MGP_BALBcJ_G0020826
protein coding gene Chr13:97930088-97954650 (-)
C3H/HeJ MGP_C3HHeJ_G0020617
protein coding gene Chr13:99934502-99959255 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021260
protein coding gene Chr13:104109633-104134454 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018829
protein coding gene Chr13:92962161-92986679 (-)
CAST/EiJ MGP_CASTEiJ_G0020135
protein coding gene Chr13:99340891-99365613 (-)
CBA/J MGP_CBAJ_G0020577
protein coding gene Chr13:108246119-108270836 (-)
DBA/2J MGP_DBA2J_G0020702
protein coding gene Chr13:96994997-97019665 (-)
FVB/NJ MGP_FVBNJ_G0020683
protein coding gene Chr13:95738728-95763385 (-)
LP/J MGP_LPJ_G0020777
protein coding gene Chr13:101202500-101228072 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020711
protein coding gene Chr13:108556038-108581769 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021301
protein coding gene Chr13:99647139-99673116 (-)
PWK/PhJ MGP_PWKPhJ_G0019888
protein coding gene Chr13:95813382-95839013 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019711
protein coding gene Chr13:95944246-95969082 (-)
WSB/EiJ MGP_WSBEiJ_G0020193
protein coding gene Chr13:100087981-100112681 (-)



Homology
more
  • Human Ortholog
    PTCD2, pentatricopeptide repeat domain 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PTCD2, pentatricopeptide repeat domain 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 79810
    neXtProt AC: NX_Q8WV60
    UniProt: Q8WV60

  • Chr Location
    5q13.2; chr5:72320367-72368395 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit abnormal mitochondrial morphology and physiology, especially in the heart, liver, skeletal muscle and kidney.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68927 NCBI Gene Model | MGI Sequence Detail 25030 C57BL/6J ±  kb
    transcript NM_026873 RefSeq | MGI Sequence Detail 1675 C57BL/6  
    polypeptide Q8R3K3 UniProt | EBI | MGI Sequence Detail 381 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      cDNA 49
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 7
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:151002 Pagliarini DJ, et al., A mitochondrial protein compendium elucidates complex I disease biology. Cell. 2008 Jul 11;134(1):112-23

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    03/19/2019
    MGI 6.13
    The Jackson Laboratory