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Pygo2 Gene Detail
Summary
  • Symbol
    Pygo2
  • Name
    pygopus 2
  • Synonyms
    1190004M21Rik, mpygo2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916161
    NCBI Gene: 68911
  • Gene Overview
    MyGene.info: PYGO2
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:89430214-89435128 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 39.12 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    29 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916161
protein coding gene Chr3:89430117-89435131 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027440
protein coding gene Chr3:89646153-89651067 (+)
A/J MGP_AJ_G0027404
protein coding gene Chr3:86679069-86683983 (+)
AKR/J MGP_AKRJ_G0027368
protein coding gene Chr3:88777988-88782902 (+)
BALB/cJ MGP_BALBcJ_G0027413
protein coding gene Chr3:86647755-86652669 (+)
C3H/HeJ MGP_C3HHeJ_G0027155
protein coding gene Chr3:88980340-88985254 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027859
protein coding gene Chr3:93030827-93035741 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025211
protein coding gene Chr3:82162721-82167658 (+)
CAST/EiJ MGP_CASTEiJ_G0026601
protein coding gene Chr3:89337117-89342036 (+)
CBA/J MGP_CBAJ_G0027129
protein coding gene Chr3:96224676-96229590 (+)
DBA/2J MGP_DBA2J_G0027267
protein coding gene Chr3:86057085-86061999 (+)
FVB/NJ MGP_FVBNJ_G0027235
protein coding gene Chr3:84397721-84402635 (+)
LP/J MGP_LPJ_G0027376
protein coding gene Chr3:90725629-90730543 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027255
protein coding gene Chr3:102430560-102435474 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027918
protein coding gene Chr3:88532866-88537780 (+)
PWK/PhJ MGP_PWKPhJ_G0026335
protein coding gene Chr3:85934840-85939745 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026154
protein coding gene Chr3:87711397-87716280 (+)
WSB/EiJ MGP_WSBEiJ_G0026683
protein coding gene Chr3:88929684-88934598 (+)



Homology
more
  • Human Ortholog
    PYGO2, pygopus family PHD finger 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    PYGO2, pygopus family PHD finger 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    1190004M21Rik
  • Links
    NCBI Gene ID: 90780
    neXtProt AC: NX_Q9BRQ0
    UniProt: Q9BRQ0

  • Chr Location
    1q21.3; chr1:154957026-154961782 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 5 alleles in 10 genetic backgrounds
    14 phenotypes from multigenic genotypes
    1 images
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit neonatal lethality, have small or absent lens, abnormal optic cup morphology, and impaired mammary gland epithelium proliferation. Mice homozygous for a knock-in allele exhibit normal development and fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000047824 Ensembl Gene Model | MGI Sequence Detail 4915 C57BL/6J ±  kb
    transcript ENSMUST00000060061 Ensembl | MGI Sequence Detail 3198 Not Applicable  
    polypeptide ENSMUSP00000053672 Ensembl | MGI Sequence Detail 405 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR011011 Zinc finger, FYVE/PHD-type
      IPR019787 Zinc finger, PHD-finger
      IPR001965 Zinc finger, PHD-type
      IPR019786 Zinc finger, PHD-type, conserved site
      IPR013083 Zinc finger, RING/FYVE/PHD-type
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 13
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 7
      Phenotypes 21
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:245023 Cantu C, et al., A cytoplasmic role of Wnt/beta-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation. Sci Signal. 2017 Feb 07;10(465)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory