Disp1
Gene Detail

Symbol Name ID

Disp1 dispatched homolog 1 (Drosophila) MGI:1916147

Synonyms

1190008H24Rik, DispA

Feature Type

protein coding gene

Genetic Map

Chromosome 1
Syntenic

Mapping data(2)

Sequence Map

Chr1:183086264-183221529 bp, - strand From NCBI annotation of GRCm38   135266 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:14133  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Disp1

Human homologs

Human Homolog		DISP1, dispatched homolog 1 (Drosophila)
NCBI Gene ID		84976
neXtProt AC		NX_Q96F81
Human Synonyms		DISPA
Human Chr (Location)		1q41; chr1:222988431-223179337 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(12) : Targeted(5) Gene trapped(6) Chemically induced(1)
 

Mice homozygous for targeted and chemically induced mutations exhibit a dorsalized neural tube, impaired heart looping, pericardial edema, large forelimbs, and abnormal head shape.

 
Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	determination of left/right symmetry, diaphragm development, ...
Component	integral to membrane, membrane
Function	hedgehog receptor activity, peptide transporter activity

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (62)    Tissues (36)    Images (27)
Theiler Stages: 12, 14, 15, 17, 21, 22, 23, 24, 28

Assay Type	Results
RNA in situ	61
Northern blot	1

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) cDNA(12) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000030768 (Evidence)
Entrez Gene	68897 (Evidence)
DFCI	TC1578610, TC1652175, TC1660213
DoTS	DT.101387519, DT.40135624, DT.40144994
NIA Mouse Gene Index	U040488, U053586
Consensus CDS Project	CCDS56661.1
International Mouse Knockout Project Status	Disp1

Sequences

Length	Strain/Species
genomic	68897	NCBI Gene Model | MGI Sequence Detail	135266	C57BL/6J
transcript	NM_026866	RefSeq | MGI Sequence Detail	5030	C57BL/6
polypeptide	Q3TDN0	UniProt | EBI | MGI Sequence Detail	1521	Not Applicable

All sequences(42) RefSeq(8) UniProt(1)

Polymorphisms

SNPs within 2kb(823 from dbSNP Build 137)    SNPs within 2kb including multiple locations(825)

Protein-related information

Resource	ID	Description
InterPro	IPR003392	Patched
InterPro	IPR000731	Sterol-sensing domain
Protein Ontology	PR:000006495	protein dispatched 1

Graphical View of Protein Domain Structure

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:171050 Thiagarajan RD, et al., Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. PLoS One. 2011;6(2):e17286
All references(39)