Disp1 MGI Mouse Gene Detail - MGI:1916147 - dispatched RND transporter family member 1

Symbol

Disp1
Name

dispatched RND transporter family member 1
Synonyms

1190008H24Rik, DispA

Feature Type

protein coding gene
IDs

MGI:1916147
NCBI Gene: 68897
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr1:183086266-183221522 bp, - strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, Syntenic
Mapping Data

2 experiments

SNPs within 2kb

817 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916147	protein coding gene	Chr1:183086264-183221535 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016900	protein coding gene	Chr1:189723406-189861801 (-)
A/J	MGP_AJ_G0016879	protein coding gene	Chr1:181971646-182108182 (-)
AKR/J	MGP_AKRJ_G0016844	protein coding gene	Chr1:187377322-187520677 (-)
BALB/cJ	MGP_BALBcJ_G0016837	protein coding gene	Chr1:182609997-182751231 (-)
C3H/HeJ	MGP_C3HHeJ_G0016661	protein coding gene	Chr1:188185626-188324703 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017300	protein coding gene	Chr1:195807003-195956018 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015007	protein coding gene	Chr1:173034917-173165034 (-)
CAST/EiJ	MGP_CASTEiJ_G0016243	protein coding gene	Chr1:187559059-187713237 (-)
CBA/J	MGP_CBAJ_G0016635	protein coding gene	Chr1:203094909-203253413 (-)
DBA/2J	MGP_DBA2J_G0016741	protein coding gene	Chr1:180749234-180890044 (-)
FVB/NJ	MGP_FVBNJ_G0016737	protein coding gene	Chr1:178885286-179022816 (-)
LP/J	MGP_LPJ_G0016816	protein coding gene	Chr1:190902699-191050868 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016769	protein coding gene	Chr1:210062530-210218158 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017337	protein coding gene	Chr1:187208959-187348059 (-)
PWK/PhJ	MGP_PWKPhJ_G0016031	protein coding gene	Chr1:179941680-180074257 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015807	protein coding gene	Chr1:186161208-186308562 (-)
WSB/EiJ	MGP_WSBEiJ_G0016306	protein coding gene	Chr1:187387789-187529284 (-)

Human Ortholog

DISP1, dispatched RND transporter family member 1

Vertebrate Orthologs

9

Human Ortholog

DISP1, dispatched RND transporter family member 1
Orthology source: HomoloGene, HGNC
Synonyms

DISPA
Links

HGNC:19711

NCBI Gene ID: 84976

neXtProt AC: NX_Q96F81

UniProt: Q96F81
Chr Location

1q41; chr1:222814514-223005995 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 14133
1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: DISP1
Gene Tree

Disp1

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Mutations/Alleles

2 with disease annotations

References

1 with disease annotations

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Phenotype Summary

64 phenotypes from 6 alleles in 6 genetic backgrounds
16 phenotypes from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (ENU)

1
Gene trapped

6
Targeted

5
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for targeted and chemically induced mutations exhibit a dorsalized neural tube, impaired heart looping, pericardial edema, large forelimbs, and abnormal head shape.

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All GO Annotations

19
GO References

7

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

72
Tissues

46
cDNA Data

13
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA DISP1

Xenbase disp1

ZFIN disp1

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Disp1 interacts with 31 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

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All Sequences

60
RefSeq

10
UniProt

2
CCDS

CCDS56661.1

Ensembl

ENSMUSG00000030768 (Evidence)
NCBI Gene

68897

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030768	Ensembl Gene Model \| MGI Sequence Detail	135257	C57BL/6J	± kb
transcript	ENSMUST00000171366	Ensembl \| MGI Sequence Detail	4687	Not Applicable
polypeptide	ENSMUSP00000126742	Ensembl \| MGI Sequence Detail	1521	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006495 protein dispatched homolog 1

(term hierarchy)
InterPro Domains

IPR003392 Protein patched/dispatched

IPR000731 Sterol-sensing domain

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All nucleic 15

cDNA 13

Other 2

Microarray probesets 4

Summaries

All 37

Developmental Gene Expression 10

Diseases 1

Gene Ontology 7

Phenotypes 13
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:236394 Roberts B, et al., Patched1 and Patched2 inhibit Smoothened non-cell autonomously. Elife. 2016 Aug 23;5

TSS for Disp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr342	Chr1:183221513-183221527 (-)	2 bp
Tssr341	Chr1:183221465-183221510 (-)	34 bp
Tssr340	Chr1:183221446-183221457 (-)	70 bp
Tssr339	Chr1:183221428-183221442 (-)	87 bp
Tssr336	Chr1:183147549-183147563 (-)	73,966 bp
Tssr335	Chr1:183147521-183147538 (-)	73,992 bp
Tssr334	Chr1:183147502-183147514 (-)	74,014 bp
Tssr333	Chr1:183147464-183147487 (-)	74,046 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/08/2019 MGI 6.14