Disp1 MGI Mouse Gene Detail - MGI:1916147 - dispatched homolog 1 (Drosophila)

Disp1 Gene Detail

Symbol

Disp1
Name

dispatched homolog 1 (Drosophila)
Synonyms

1190008H24Rik, DispA

Feature Type

protein coding gene
IDs

MGI:1916147
NCBI Gene: 68897

Sequence Map

Chr1:183086266-183221522 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

135257 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, Syntenic
Mapping Data

2 experiments

Human Ortholog

DISP1, dispatched RND transporter family member 1

Vertebrate Orthologs

9

Human Ortholog

DISP1, dispatched RND transporter family member 1
Orthology source: HomoloGene, HGNC
Synonyms

DISPA
Links

HGNC:19711

NCBI Gene ID: 84976

neXtProt AC: NX_Q96F81
Chr Location

1q41; chr1:222814514-223005995 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 14133
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: DISP1
Gene Tree

Disp1

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Mutations/Alleles

2 with disease annotations

References

1 with disease annotations

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Phenotype Summary

62 phenotypes from 6 alleles in 6 genetic backgrounds
16 phenotypes from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (ENU)

1
Gene trapped

6
Targeted

5
Incidental Mutations

Mutagenetix

Mice homozygous for targeted and chemically induced mutations exhibit a dorsalized neural tube, impaired heart looping, pericardial edema, large forelimbs, and abnormal head shape.

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All GO Annotations

17
GO References

7

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

62
Tissues

36
cDNA Data

12
Literature Summary

10

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

GEISHA DISP1

Xenbase disp1

ZFIN disp1

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Disp1 interacts with 31 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

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All Sequences

52
RefSeq

10
UniProt

2
CCDS

CCDS56661.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000050524	VEGA Gene Model \| MGI Sequence Detail	135257	C57BL/6J	± kb
transcript	OTTMUST00000128142	VEGA \| MGI Sequence Detail	4687	Not Applicable
polypeptide	OTTMUSP00000068981	VEGA \| MGI Sequence Detail	1521	Not Applicable

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SNPs within 2kb

817 from dbSNP Build 142

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UniProt

2 Sequences
Protein Ontology

PR:000006495 protein dispatched homolog 1
InterPro Domains

IPR003392 Protein patched/dispatched

IPR000731 Sterol-sensing domain

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All nucleic 13

cDNA 12

Other 1

Microarray probesets 4

Summaries

All 36

Developmental Gene Expression 10

Diseases 1

Gene Ontology 7

Phenotypes 13
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:171050 Thiagarajan RD, et al., Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. PLoS One. 2011;6(2):e17286

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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