Disp1
Gene Detail

Symbol

Name
ID

Disp1
dispatched homolog 1 (Drosophila)
MGI:1916147

Synonyms

1190008H24Rik, DispA

Feature Type

protein coding gene

Genetic Map

Chromosome 1
Syntenic

Mapping data(2)

Sequence Map

Chr1:183086266-183221522 bp, - strand From Ensembl annotation of GRCm38   135257 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:14133  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Disp1

Human
homologs

Human Homolog		DISP1, dispatched homolog 1 (Drosophila)
NCBI Gene ID		84976
neXtProt AC		NX_Q96F81
Human Synonyms		DISPA
Human Chr (Location)		1q41; chr1:222815089-223005995 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(12) : Chemically induced (ENU)(1) Gene trapped(6) Targeted(5)
Incidental mutations (data from Mutagenetix )
 

Mice homozygous for targeted and chemically induced mutations exhibit a dorsalized neural tube, impaired heart looping, pericardial edema, large forelimbs, and abnormal head shape.

 
Mutations Annotated to Human Diseases (2)   

Interactions

Disp1 interacts with 31 markers (Mir9-1, Mir9-2, Mir9-3, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (19 annotations)

Process	determination of left/right symmetry, diaphragm development, ...
Component	integral component of membrane, membrane
Function	hedgehog receptor activity, peptide transporter activity

External Resources: FuncBase

Expression

Literature Summary: (10 records)

Data Summary: Results (62)    Tissues (36)    Images (27)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	61
Northern blot	1

cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(13) cDNA(12) Other(1)
Microarray probesets(4)

Other database
links

Ensembl Gene Model	ENSMUSG00000030768 (Evidence)
Entrez Gene	68897 (Evidence)
DFCI	TC1578610, TC1652175, TC1660213
DoTS	DT.101387519, DT.40144994, DT.40135624
NIA Mouse Gene Index	U053586, U040488
Consensus CDS Project	CCDS56661.1
International Mouse Knockout Project Status	Disp1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000030768	Ensembl Gene Model | MGI Sequence Detail	135257	C57BL/6J
transcript	ENSMUST00000171366	Ensembl | MGI Sequence Detail	4687	Not Applicable
polypeptide	ENSMUSP00000126742	Ensembl | MGI Sequence Detail	1521	Not Applicable

All sequences(49) RefSeq(10) UniProt(1)

Polymorphisms

SNPs within 2kb(823 from dbSNP Build 137)    SNPs within 2kb including multiple locations(825)

Protein-related
information

Resource	ID	Description
InterPro	IPR003392	Patched
InterPro	IPR000731	Sterol-sensing domain
Protein Ontology	PR:000006495	protein dispatched homolog 1

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:171050 Thiagarajan RD, et al., Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. PLoS One. 2011;6(2):e17286
All references(39)