Mtmr14
Gene Detail

Symbol Name ID

Mtmr14 myotubularin related protein 14 MGI:1916075

Synonyms

1110061O04Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 6

52.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr6:113237843-113281387 bp, + strand From VEGA annotation of GRCm38   43545 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:11203  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Mtmr14

Human homologs

Human Homolog		MTMR14, myotubularin related protein 14
NCBI Gene ID		64419
neXtProt AC		NX_Q8NCE2
Human Synonyms		C3orf29
Human Chr (Location)		3p26; chr3:9691117-9744078 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MTMR14

Alleles and phenotypes

All alleles(8) : Targeted(3) Gene trapped(5)
 

Mice homozygous for a knock-out allele exhibit impaired coordination, decreased exercise endurance, increased muscle fatigue, and muscle atrophy associated with impaired muscular calcium homeostasis.

 

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	dephosphorylation
Component	cytoplasm, perinuclear region of cytoplasm, ...
Function	hydrolase activity, phosphatase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (1)    Tissues (1)   
Theiler Stages: 22

Assay Type	Results
RNA in situ	1

cDNA source data(132)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(132) cDNA(132)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000031092 (Evidence)
Ensembl Gene Model	ENSMUSG00000030269 (Evidence)
Entrez Gene	97287 (Evidence)
UniGene	197816
DFCI	TC1575635, TC1602405, TC1611722, TC1652632
DoTS	DT.101281952, DT.101360967, DT.101394665, DT.55260018
NIA Mouse Gene Index	U007264
EC	3.1.3.-
Consensus CDS Project	CCDS20412.2
International Mouse Knockout Project Status	Mtmr14

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031092	VEGA Gene Model | MGI Sequence Detail	43545	C57BL/6J
transcript	OTTMUST00000077023	VEGA | MGI Sequence Detail	2486	Not Applicable
polypeptide	OTTMUSP00000040619	VEGA | MGI Sequence Detail	648	Not Applicable

All sequences(97) RefSeq(2) UniProt(11)

Polymorphisms

SNPs(157 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016130	Protein-tyrosine phosphatase, active site
Protein Ontology	PR:000010735	myotubularin-related protein 14

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(36)

Other accession IDs

MGI:2141698, MGI:2141743