About   Help   FAQ
Mtmr14
Gene Detail
Symbol

Name
ID
Mtmr14
myotubularin related protein 14
MGI:1916075
Synonyms
1110061O04Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 6
52.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:113237843-113281387 bp, + strand
From VEGA annotation of GRCm38

  43545 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11203  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Mtmr14

Human
homologs
Human Homolog MTMR14, myotubularin related protein 14
NCBI Gene ID 64419
neXtProt AC  NX_Q8NCE2
Human Synonyms  C3orf29
Human Chr (Location)  3p26; chr3:9649433-9702394 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human MTMR14
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(5) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit impaired coordination, decreased exercise endurance, increased muscle fatigue, and muscle atrophy associated with impaired muscular calcium homeostasis.
 
Interactions
Mtmr14 interacts with 250 markers (Mir15a, Mir18, Mir18b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process dephosphorylation
Component cytoplasm, perinuclear region of cytoplasm, ...
Function 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (1)    Tissues (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
cDNA source data(134)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(134) cDNA(134)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000031092 (Evidence)
Ensembl Gene ModelENSMUSG00000030269 (Evidence)
Entrez Gene97287 (Evidence)
UniGene197816
DFCITC1575635, TC1602405, TC1611722, TC1652632
DoTSDT.101281952, DT.101360967, DT.101394665, DT.55260018
NIA Mouse Gene IndexU007264
EC3.1.3.-
Consensus CDS ProjectCCDS20412.2
International Mouse Knockout Project StatusMtmr14
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031092 VEGA Gene Model | MGI Sequence Detail 43545 C57BL/6J ±  kb
transcript OTTMUST00000077023 VEGA | MGI Sequence Detail 2486 Not Applicable 
polypeptide OTTMUSP00000040619 VEGA | MGI Sequence Detail 648 Not Applicable 

For the selected sequences
All sequences(110) RefSeq(15) UniProt(11)
Polymorphisms
SNPs within 2kb(218 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010569 Myotubularin-related
InterPro IPR016130 Protein-tyrosine phosphatase, active site
Protein Ontology PR:000010735 myotubularin-related protein 14
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(38)
Other
accession IDs
MGI:2141698, MGI:2141743

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2014
MGI 5.20
The Jackson Laboratory