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Nexn
Gene Detail
Symbol

Name
ID
Nexn
nexilin
MGI:1916060
Synonyms
1110046H09Rik, nF actin binding protein
Feature Type
protein coding gene
Genetic Map
Chromosome 3
77.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:152236986-152266320 bp, - strand
From Ensembl annotation of GRCm38

  29335 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:44892  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: NEXN
Gene Tree: Nexn

Human
homologs
NEXN, nexilin (F actin binding protein)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 91624
neXtProt AC: NX_Q0ZGT2

Human Synonyms: CMH20, NELIN

Human Chr (Location): 1p31.1; chr1:77888515-77948643 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human NEXN

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(3) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Nexn interacts with 128 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cardiac muscle fiber development, protein phosphorylation, ...
Component cell junction, cell-substrate adherens junction, ...
Function actin binding, actin filament binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (76)    Tissues (5)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 76
cDNA source data(55)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nexn ; ZFIN nexn    NEW 
Molecular
reagents
All nucleic(55) cDNA(55)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000039103 (Evidence)
Entrez Gene 68810 (Evidence)
UniGene 200188
DFCI TC1768295, TC1700291, TC1580276
DoTS DT.94254021, DT.94254005, DT.101369046, DT.60118387, DT.101369045, DT.101364901
NIA Mouse Gene Index U024767
Consensus CDS Project CCDS38673.1
International Mouse Phenotyping Consortium Status Nexn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039103 Ensembl Gene Model | MGI Sequence Detail 29335 C57BL/6J ±  kb
transcript ENSMUST00000046045 Ensembl | MGI Sequence Detail 2562 Not Applicable 
polypeptide ENSMUSP00000037120 Ensembl | MGI Sequence Detail 607 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(24) UniProt(4)
Polymorphisms
SNPs within 2kb(154 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR020675 Myosin light chain kinase-related
Protein Ontology PR:000011159 nexilin
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:211935 Dorval V, et al., Gene and MicroRNA transcriptome analysis of Parkinson's related LRRK2 mouse models. PLoS One. 2014;9(1):e85510
All references(33)
Other
accession IDs
MGI:2139594

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory