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Nexn Gene Detail
Summary
  • Symbol
    Nexn
  • Name
    nexilin
  • Synonyms
    1110046H09Rik, nF actin binding protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916060
    NCBI Gene: 68810
  • Alliance
  • Transcription Start Sites
    31 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:152236982-152266350 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 77.07 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    155 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916060
protein coding gene Chr3:152236982-152266351 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027989
protein coding gene Chr3:156089387-156121920 (-)
A/J MGP_AJ_G0027948
protein coding gene Chr3:150430669-150460452 (-)
AKR/J MGP_AKRJ_G0027914
protein coding gene Chr3:154388658-154419704 (-)
BALB/cJ MGP_BALBcJ_G0027960
protein coding gene Chr3:150267318-150297353 (-)
C3H/HeJ MGP_C3HHeJ_G0027690
protein coding gene Chr3:154833137-154865115 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028403
protein coding gene Chr3:161236075-161266228 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025741
protein coding gene Chr3:145266717-145296247 (-)
CAST/EiJ MGP_CASTEiJ_G0027143
protein coding gene Chr3:154908575-154938677 (-)
CBA/J MGP_CBAJ_G0027665
protein coding gene Chr3:167018837-167050933 (-)
DBA/2J MGP_DBA2J_G0027805
protein coding gene Chr3:149536391-149567145 (-)
FVB/NJ MGP_FVBNJ_G0027772
protein coding gene Chr3:146913285-146942578 (-)
LP/J MGP_LPJ_G0027916
protein coding gene Chr3:157465243-157494815 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027805
protein coding gene Chr3:175551337-175582436 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028462
protein coding gene Chr3:154083445-154114919 (-)
PWK/PhJ MGP_PWKPhJ_G0026866
protein coding gene Chr3:149422274-149452167 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026694
protein coding gene Chr3:152242792-152272595 (-)
WSB/EiJ MGP_WSBEiJ_G0027223
protein coding gene Chr3:155092562-155122320 (-)



Homology
more
  • Human Ortholog
    NEXN, nexilin F-actin binding protein
  • Vertebrate Orthologs
    8
  • Human Ortholog
    NEXN, nexilin F-actin binding protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CMH20, NELIN
  • Links
    NCBI Gene ID: 91624
    neXtProt AC: NX_Q0ZGT2
    UniProt: Q0ZGT2

  • Chr Location
    1p31.1; chr1:77888515-77946329 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Nexn mouse models; 2 with human NEXN associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit postnatal lethality with endomyocardial fibroelastosis, cardiac hypertrophy and dilated cardiomyopathy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039103 Ensembl Gene Model | MGI Sequence Detail 29369 C57BL/6J ±  kb
    transcript ENSMUST00000199423 Ensembl | MGI Sequence Detail 2016 Not Applicable  
    polypeptide ENSMUSP00000142936 Ensembl | MGI Sequence Detail 671 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 57
      cDNA 57

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2139594
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 6
      Phenotypes 6
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:243708 Bang ML, Animal Models of Congenital Cardiomyopathies Associated With Mutations in Z-Line Proteins. J Cell Physiol. 2017 Jan;232(1):38-52

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory