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Nexn
Gene Detail
Symbol

Name
ID
Nexn
nexilin
MGI:1916060
Synonyms
1110046H09Rik, nF actin binding protein
Feature Type
protein coding gene
Genetic Map
Chromosome 3
77.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:152236986-152266320 bp, - strand
From Ensembl annotation of GRCm38

  29335 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:44892  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Nexn

Human
homologs
Human Homolog NEXN, nexilin (F actin binding protein)
NCBI Gene ID 91624
neXtProt AC  NX_Q0ZGT2
Human Synonyms  CMH20, NELIN
Human Chr (Location)  1p31.1; chr1:77888515-77946324 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human NEXN
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(3) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Nexn interacts with 128 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cardiac muscle fiber development, protein phosphorylation, ...
Component cell junction, cell-substrate adherens junction, ...
Function actin binding, actin filament binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (76)    Tissues (5)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 76
cDNA source data(55)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(55) cDNA(55)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000039103 (Evidence)
Entrez Gene68810 (Evidence)
UniGene200188
DFCITC1580276, TC1700291, TC1768295
DoTSDT.101364901, DT.101369045, DT.101369046, DT.60118387, DT.94254005, DT.94254021
NIA Mouse Gene IndexU024767
Consensus CDS ProjectCCDS38673.1
International Mouse Knockout Project StatusNexn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039103 Ensembl Gene Model | MGI Sequence Detail 29335 C57BL/6J ±  kb
transcript ENSMUST00000046045 Ensembl | MGI Sequence Detail 2562 Not Applicable 
polypeptide ENSMUSP00000037120 Ensembl | MGI Sequence Detail 607 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(28) UniProt(4)
Polymorphisms
SNPs within 2kb(154 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR020675 Myosin light chain kinase-related
Protein Ontology PR:000011159 nexilin
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:209602 Li CL, et al., SRF phosphorylation by glycogen synthase kinase-3 promotes axon growth in hippocampal neurons. J Neurosci. 2014 Mar 12;34(11):4027-42
All references(34)
Other
accession IDs
MGI:2139594

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory