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Mypn Gene Detail
Summary
  • Symbol
    Mypn
  • Name
    myopalladin
  • Synonyms
    1110056A04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916052
    NCBI Gene: 68802
  • Gene Overview
    MyGene.info: MYPN
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:63115795-63203952 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 32.54 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    330 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916052
protein coding gene Chr10:63115795-63203952 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017313
protein coding gene Chr10:62616684-62710039 (-)
A/J MGP_AJ_G0017291
protein coding gene Chr10:60665930-60756309 (-)
AKR/J MGP_AKRJ_G0017251
protein coding gene Chr10:62270977-62366696 (-)
BALB/cJ MGP_BALBcJ_G0017251
protein coding gene Chr10:60780026-60868355 (-)
C3H/HeJ MGP_C3HHeJ_G0017074
protein coding gene Chr10:62181420-62278457 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017709
protein coding gene Chr10:64868984-64964940 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015399
protein coding gene Chr10:57602222-57690627 (-)
CAST/EiJ MGP_CASTEiJ_G0016645
protein coding gene Chr10:62243635-62345023 (-)
CBA/J MGP_CBAJ_G0017046
protein coding gene Chr10:67345609-67441955 (-)
DBA/2J MGP_DBA2J_G0017151
protein coding gene Chr10:59937057-60026071 (-)
FVB/NJ MGP_FVBNJ_G0017145
protein coding gene Chr10:59211405-59303582 (-)
LP/J MGP_LPJ_G0017225
protein coding gene Chr10:63022761-63117200 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017173
protein coding gene Chr10:69481082-69583391 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017747
protein coding gene Chr10:62113299-62203665 (-)
PWK/PhJ MGP_PWKPhJ_G0016428
protein coding gene Chr10:59822073-59914579 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016210
protein coding gene Chr10:61454097-61548210 (-)
WSB/EiJ MGP_WSBEiJ_G0016709
protein coding gene Chr10:62064830-62156807 (-)



Homology
more
  • Human Ortholog
    MYPN, myopalladin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MYPN, myopalladin
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CMD1DD, CMH22, MYOP, NEM11, RCM4
  • Links
    NCBI Gene ID: 84665
    neXtProt AC: NX_Q86TC9
    UniProt: Q86TC9

  • Chr Location
    10q21.3; chr10:68087908-68212017 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 23778
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MYPN
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Mypn mouse models; 1 with human MYPN associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68802 NCBI Gene Model | MGI Sequence Detail 88158 C57BL/6J ±  kb
    transcript NM_182992 RefSeq | MGI Sequence Detail 5246 C57BL/6  
    polypeptide Q5DTJ9 UniProt | EBI | MGI Sequence Detail 1315 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 15
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2143695
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 3
      Diseases 2
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:248575 Miyatake S, et al., Biallelic Mutations in MYPN, Encoding Myopalladin, Are Associated with Childhood-Onset, Slowly Progressive Nemaline Myopathy. Am J Hum Genet. 2017 Jan 5;100(1):169-178

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory