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Mypn Gene Detail
Summary
  • Symbol
    Mypn
  • Name
    myopalladin
  • Synonyms
    1110056A04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916052
    NCBI Gene: 68802
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:62951574-63039731 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 32.54 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2552 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916052
 protein coding gene Chr10:62951574-63039731 (-)
129S1/SvImJ ENSMUSG00200026236
 protein coding gene Chr10:59624387-59712534 (-)
A/J ENSMUSG00195026645
 protein coding gene Chr10:59931762-60019944 (-)
AKR/J ENSMUSG00220037066
 protein coding gene Chr10:59625074-59713259 (-)
BALB/cJ ENSMUSG00180022325
 protein coding gene Chr10:59974088-60062277 (-)
C3H/HeJ ENSMUSG00175023532
 protein coding gene Chr10:59831539-59919695 (-)
C57BL/6NJ ENSMUSG00215023860
 protein coding gene Chr10:59572156-59660325 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015399
 protein coding gene Chr10:57602222-57690627 (-)
CAST/EiJ ENSTCUG00005027173
 protein coding gene Chr10:59617957-59708141 (-)
CBA/J ENSMUSG00210034132
 protein coding gene Chr10:59709845-59798002 (-)
DBA/2J ENSMUSG00185040998
 protein coding gene Chr10:60051443-60139617 (-)
FVB/NJ ENSMUSG00205030869
 protein coding gene Chr10:59723543-59811726 (-)
JF1/MsJ ENSUMUG00000018920
 protein coding gene Chr10:61289704-61378384 (-)
LP/J ENSMUSG00230014658
 protein coding gene Chr10:61854304-61942475 (-)
NOD/ShiLtJ ENSMUSG00190028575
 protein coding gene Chr10:60037077-60125282 (-)
NZO/HlLtJ ENSMUSG00225044010
 protein coding gene Chr10:66135338-66223512 (-)
PWK/PhJ ENSLUMG00010021844
 protein coding gene Chr10:59678647-59767998 (-)
SPRET/EiJ ENSMSPG00010021538
 protein coding gene Chr10:61221859-61311066 (-)
WSB/EiJ ENSIUOG00005040954
 protein coding gene Chr10:59610156-59697985 (-)



Homology
more
  • Human Ortholog
    MYPN, myopalladin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYPN, myopalladin
  • Synonyms
    CMD1DD, CMH22, CMYO24, CMYP24, MYOP, NEM11, RCM4
  • Links
    NCBI Gene ID: 84665
    UniProt: Q86TC9

  • Chr Location
    10q21.3; chr10:68087897-68212017 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Mypn mouse models; 2 with human MYPN associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 3 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a nonsense mutation exhibit Z-streaming and nemaline-like bodies in skeletal muscle, suggesting the presence of mild nemaline-like myopathy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    643
  • Tissues
    8
  • cDNA Data
    15
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68802 NCBI Gene Model | MGI Sequence Detail 88158 C57BL/6J ±  kb
    transcript NM_182992 RefSeq | MGI Sequence Detail 5246 C57BL/6  
    polypeptide Q5DTJ9 UniProt | EBI | MGI Sequence Detail 1315 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 15
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2143695
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 4
      Diseases 2
      Gene Ontology 8
      Phenotypes 21
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:388821 Hand SM, et al., Loss of Methyltransferase and Hypomethylated m6A Sarcomere Transcripts Leading to Early-Onset Dilated Cardiomyopathy. Circulation. 2025 Jun 10;151(23):1692-1695
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory