Elovl5
Gene Detail

Symbol

Name
ID

Elovl5
ELOVL family member 5, elongation of long chain fatty acids (yeast)
MGI:1916051

Synonyms

1110059L23Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 9
43.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr9:77917364-77984519 bp, + strand From VEGA annotation of GRCm38   67156 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:41449  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Elovl5

Human
homologs

Human Homolog		ELOVL5, ELOVL fatty acid elongase 5
NCBI Gene ID		60481
neXtProt AC		NX_Q9NYP7
Human Synonyms		dJ483K16.1, HELO1, SCA38
Human Chr (Location)		6p12.1; chr6:53267398-53349179 (-)  GRCh38
Disease Associations		(1) Diseases Associated with Human ELOVL5

Mutations,
alleles, and
phenotypes

All mutations/alleles(149) : Gene trapped(146) Radiation induced(1) Targeted(2)
Genomic Mutations involving Elovl5 (1)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a gene trapped allele have defects in fatty acid synthesis in the liver that result in hepatic steatosis. Also, majority of female mice have defects in female fertility.

 

Interactions

Elovl5 interacts with 308 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (19 annotations)

Process	fatty acid biosynthetic process, fatty acid elongation, monounsaturated fatty acid, ...
Component	cell projection, cytoplasm, ...
Function	fatty acid elongase activity, transferase activity

External Resources: FuncBase

Expression

Literature Summary: (4 records)

Data Summary: Results (96)    Tissues (95)    Images (21)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	94
RT-PCR	2

cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(19) cDNA(18) Primer pair(1)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000022986 (Evidence)
Ensembl Gene Model	ENSMUSG00000032349 (Evidence)
Entrez Gene	68801 (Evidence)
DFCI	TC1573390
DoTS	DT.101737958, DT.101381056, DT.91360977, DT.534201
NIA Mouse Gene Index	U010772
EC	2.3.1.199
Consensus CDS Project	CCDS23355.1
International Mouse Knockout Project Status	Elovl5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022986	VEGA Gene Model | MGI Sequence Detail	67156	C57BL/6J
transcript	OTTMUST00000055326	VEGA | MGI Sequence Detail	2782	Not Applicable
polypeptide	OTTMUSP00000026486	VEGA | MGI Sequence Detail	299	Not Applicable

All sequences(54) RefSeq(6) UniProt(4)

Polymorphisms

SNPs within 2kb(476 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR002076	GNS1/SUR4 membrane protein
Protein Ontology	PR:000007040	elongation of very long chain fatty acids protein 5

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:216600 Lau CG, et al., Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil. Mol Reprod Dev. 2014 Nov;81(11):994-1008
All references(45)

Other
accession IDs

MGI:2143114, MGI:2143235