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Rgmb Gene Detail
Summary
  • Symbol
    Rgmb
  • Name
    repulsive guidance molecule family member B
  • Synonyms
    1110059F19Rik, DRAGON, RGM domain family, member B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916049
    NCBI Gene: 68799
  • Gene Overview
    MyGene.info: RGMB
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:15804661-15831817 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 8.96 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    77 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916049
protein coding gene Chr17:15804661-15831817 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023179
protein coding gene Chr17:13673845-13695135 (-)
A/J MGP_AJ_G0023145
protein coding gene Chr17:13406254-13426525 (-)
AKR/J MGP_AKRJ_G0023115
protein coding gene Chr17:13385132-13405394 (-)
BALB/cJ MGP_BALBcJ_G0023145
protein coding gene Chr17:13361236-13382132 (-)
C3H/HeJ MGP_C3HHeJ_G0022906
protein coding gene Chr17:13570541-13590853 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023588
protein coding gene Chr17:14288313-14308598 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021100
protein coding gene Chr17:11404890-11424965 (-)
CAST/EiJ MGP_CASTEiJ_G0022423
protein coding gene Chr17:13434552-13504363 (-)
CBA/J MGP_CBAJ_G0022882
protein coding gene Chr17:14792636-14813252 (-)
DBA/2J MGP_DBA2J_G0023015
protein coding gene Chr17:13117631-13137921 (-)
FVB/NJ MGP_FVBNJ_G0022981
protein coding gene Chr17:12968285-12991692 (-)
LP/J MGP_LPJ_G0023089
protein coding gene Chr17:13653498-13676446 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023004
protein coding gene Chr17:14291788-14314461 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023624
protein coding gene Chr17:13620691-13643470 (-)
PWK/PhJ MGP_PWKPhJ_G0022171
protein coding gene Chr17:12567930-12641240 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022001
protein coding gene Chr17:12572096-12592624 (-)
WSB/EiJ MGP_WSBEiJ_G0022482
protein coding gene Chr17:13939278-13959590 (-)



Homology
more
  • Human Ortholog
    RGMB, repulsive guidance molecule BMP co-receptor b
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RGMB, repulsive guidance molecule BMP co-receptor b
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DRAGON
  • Links
    NCBI Gene ID: 285704
    neXtProt AC: NX_Q6NW40
    UniProt: Q6NW40

  • Chr Location
    5q15; chr5:98768386-98796494 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 65355
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RGMB
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit lethality at 2 to 3 weeks after birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 68799 NCBI Gene Model | MGI Sequence Detail 27157 C57BL/6J ±  kb
transcript NM_178615 RefSeq | MGI Sequence Detail 2633 Not Specified  
polypeptide Q7TQ33 UniProt | EBI | MGI Sequence Detail 436 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • InterPro Domains
    IPR016123 Mog1/PsbP, alpha/beta/alpha sandwich
    IPR009496 Repulsive guidance molecule, C-terminal
    IPR010536 Repulsive guidance molecule, N-terminal
    IPR033608 RGM domain family member B
Molecular
Reagents
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  • All nucleic 21
    cDNA 18
    Primer pair 2
    Other 1

    Microarray probesets 8
References
more
  • Summaries
    All 37
    Developmental Gene Expression 13
    Gene Ontology 6
    Phenotypes 4
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:258289 Liu W, et al., RGMb protects against acute kidney injury by inhibiting tubular cell necroptosis via an MLKL-dependent mechanism. Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1475-E1484

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory