Rgmb MGI Mouse Gene Detail - MGI:1916049 - repulsive guidance molecule family member B

Symbol

Rgmb
Name

repulsive guidance molecule family member B
Synonyms

1110059F19Rik, DRAGON, RGM domain family, member B

Feature Type

protein coding gene
IDs

MGI:1916049
NCBI Gene: 68799
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr17:16024923-16051508 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 8.96 cM
Mapping Data

1 experiment

SNPs within 2kb

799 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916049	protein coding gene	Chr17:16023450-16051508 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023179	protein coding gene	Chr17:13673845-13695135 (-)
A/J	MGP_AJ_G0023145	protein coding gene	Chr17:13406254-13426525 (-)
AKR/J	MGP_AKRJ_G0023115	protein coding gene	Chr17:13385132-13405394 (-)
BALB/cJ	MGP_BALBcJ_G0023145	protein coding gene	Chr17:13361236-13382132 (-)
C3H/HeJ	MGP_C3HHeJ_G0022906	protein coding gene	Chr17:13570541-13590853 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023588	protein coding gene	Chr17:14288313-14308598 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021100	protein coding gene	Chr17:11404890-11424965 (-)
CAST/EiJ	MGP_CASTEiJ_G0022423	protein coding gene	Chr17:13434552-13504363 (-)
CBA/J	MGP_CBAJ_G0022882	protein coding gene	Chr17:14792636-14813252 (-)
DBA/2J	MGP_DBA2J_G0023015	protein coding gene	Chr17:13117631-13137921 (-)
FVB/NJ	MGP_FVBNJ_G0022981	protein coding gene	Chr17:12968285-12991692 (-)
LP/J	MGP_LPJ_G0023089	protein coding gene	Chr17:13653498-13676446 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023004	protein coding gene	Chr17:14291788-14314461 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023624	protein coding gene	Chr17:13620691-13643470 (-)
PWK/PhJ	MGP_PWKPhJ_G0022171	protein coding gene	Chr17:12567930-12641240 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022001	protein coding gene	Chr17:12572096-12592624 (-)
WSB/EiJ	MGP_WSBEiJ_G0022482	protein coding gene	Chr17:13939278-13959590 (-)

Human Ortholog

RGMB, repulsive guidance molecule BMP co-receptor b

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RGMB, repulsive guidance molecule BMP co-receptor b
Synonyms

DRAGON
Links

HGNC:26896

NCBI Gene ID: 285704

UniProt: Q6NW40
Chr Location

5q15; chr5:98768632-98798643 (+) GRCh38

MGI Vertebrate Homology

Rgmb stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RGMB
Gene Tree

Rgmb

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Targeted

4
Find Mice (IMSR)

13 strains or lines available

Mice homozygous for a knock-out allele exhibit lethality at 2 to 3 weeks after birth.

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All GO Annotations

18
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1188
Tissues

218
cDNA Data

17
Literature Summary

19

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rgmb

ZFIN rgmb

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All Sequences

67
RefSeq

12
UniProt

7
CCDS

CCDS37455.1

Ensembl

ENSMUSG00000048027 (Evidence)
NCBI Gene

68799

			Length	Strain/Species	Flank
genomic	68799	NCBI Gene Model \| MGI Sequence Detail	26586	C57BL/6J	± kb
transcript	NM_001372258	RefSeq \| MGI Sequence Detail	4481	C57BL/6
polypeptide	Q7TQ33	UniProt \| EBI \| MGI Sequence Detail	436	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000030787 repulsive guidance molecule B

(term hierarchy)
InterPro Domains

IPR040287 Repulsive guidance molecule

IPR009496 Repulsive guidance molecule, C-terminal

IPR010536 Repulsive guidance molecule, N-terminal
GlyGen

Q7TQ33 3 sites

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All nucleic 22

cDNA 18

Primer pair 2

Other 2

Microarray probesets 8

Summaries

All 47

Developmental Gene Expression 19

Gene Ontology 7

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:340034 Park JS, et al., Targeting PD-L2-RGMb overcomes microbiome-related immunotherapy resistance. Nature. 2023 May;617(7960):377-385

TSS for Rgmb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr146542	Chr17:16051490-16051513 (-)	6 bp
Tssr146541	Chr17:16051434-16051457 (-)	62 bp
Tssr146540	Chr17:16051294-16051364 (-)	179 bp
Tssr146539	Chr17:16051092-16051111 (-)	406 bp
Tssr146538	Chr17:16051066-16051078 (-)	436 bp
Tssr146537	Chr17:16051048-16051059 (-)	454 bp
Tssr146536	Chr17:16050144-16050164 (-)	1,354 bp
Tssr146535	Chr17:16050087-16050101 (-)	1,414 bp
Tssr146534	Chr17:16046783-16046852 (-)	4,690 bp
Tssr146533	Chr17:16046750-16046774 (-)	4,746 bp
Tssr146532	Chr17:16027342-16027356 (-)	24,159 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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