Rgmb MGI Mouse Gene Detail - MGI:1916049 - repulsive guidance molecule family member B

Rgmb Gene Detail

Symbol

Rgmb
Name

repulsive guidance molecule family member B
Synonyms

1110059F19Rik, DRAGON, RGM domain family, member B

Feature Type

protein coding gene
IDs

MGI:1916049
NCBI Gene: 68799
Gene Overview

MyGene.info: RGMB

Sequence Map

Chr17:15806253-15826586 bp, - strand
From Ensembl annotation of GRCm38

Mouse Genome Browser
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Sequence

20334 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 8.96 cM
Mapping Data

1 experiment

Human Ortholog

RGMB, repulsive guidance molecule family member b

Vertebrate Orthologs

10

Human Ortholog

RGMB, repulsive guidance molecule family member b
Orthology source: HomoloGene, HGNC
Synonyms

DRAGON
Links

HGNC:26896

NCBI Gene ID: 285704

neXtProt AC: NX_Q6NW40

UniProt: Q6NW40
Chr Location

5q15; chr5:98768386-98796494 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 65355
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: RGMB
Gene Tree

Rgmb

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
3 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

1
Targeted

1
Find Mice (IMSR)

4 strains or lines available

Mice homozygous for a knock-out allele exhibit lethality at 2 to 3 weeks after birth.

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All GO Annotations

11
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

436
Tissues

190
cDNA Data

16
Literature Summary

12

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN rgmb

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Rgmb interacts with 199 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

31
RefSeq

8
UniProt

3
CCDS

CCDS37455.1

Ensembl

ENSMUSG00000048027 (Evidence)
NCBI Gene

68799

			Length	Strain/Species	Flank
genomic	ENSMUSG00000048027	Ensembl Gene Model \| MGI Sequence Detail	20334	C57BL/6J	± kb
transcript	ENSMUST00000170578	Ensembl \| MGI Sequence Detail	2633	Not Applicable
polypeptide	ENSMUSP00000126177	Ensembl \| MGI Sequence Detail	436	Not Applicable

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SNPs within 2kb

61 from dbSNP Build 142

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UniProt

3 Sequences
Protein Ontology

PR:000030787 RGM domain family member B

(term hierarchy)
InterPro Domains

IPR009496 Repulsive guidance molecule, C-terminal

IPR010536 Repulsive guidance molecule, N-terminal

IPR033608 RGM domain family member B

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All nucleic 19

cDNA 17

Primer pair 1

Other 1

Microarray probesets 8

Summaries

All 34

Developmental Gene Expression 12

Gene Ontology 5

Phenotypes 3
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:235517 Kam JW, et al., RGMB and neogenin control cell differentiation in the developing olfactory epithelium. Development. 2016 May 1;143(9):1534-46

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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