Rgmb MGI Mouse Gene Detail - MGI:1916049 - repulsive guidance molecule family member B

Symbol

Rgmb
Name

repulsive guidance molecule family member B
Synonyms

1110059F19Rik, DRAGON, RGM domain family, member B

Feature Type

protein coding gene
IDs

MGI:1916049
NCBI Gene: 68799
Gene Overview

MyGene.info: RGMB
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr17:15804661-15831817 bp, - strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 8.96 cM
Mapping Data

1 experiment

SNPs within 2kb

77 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916049	protein coding gene	Chr17:15803188-15831817 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023179	protein coding gene	Chr17:13673845-13695135 (-)
A/J	MGP_AJ_G0023145	protein coding gene	Chr17:13406254-13426525 (-)
AKR/J	MGP_AKRJ_G0023115	protein coding gene	Chr17:13385132-13405394 (-)
BALB/cJ	MGP_BALBcJ_G0023145	protein coding gene	Chr17:13361236-13382132 (-)
C3H/HeJ	MGP_C3HHeJ_G0022906	protein coding gene	Chr17:13570541-13590853 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023588	protein coding gene	Chr17:14288313-14308598 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021100	protein coding gene	Chr17:11404890-11424965 (-)
CAST/EiJ	MGP_CASTEiJ_G0022423	protein coding gene	Chr17:13434552-13504363 (-)
CBA/J	MGP_CBAJ_G0022882	protein coding gene	Chr17:14792636-14813252 (-)
DBA/2J	MGP_DBA2J_G0023015	protein coding gene	Chr17:13117631-13137921 (-)
FVB/NJ	MGP_FVBNJ_G0022981	protein coding gene	Chr17:12968285-12991692 (-)
LP/J	MGP_LPJ_G0023089	protein coding gene	Chr17:13653498-13676446 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023004	protein coding gene	Chr17:14291788-14314461 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023624	protein coding gene	Chr17:13620691-13643470 (-)
PWK/PhJ	MGP_PWKPhJ_G0022171	protein coding gene	Chr17:12567930-12641240 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022001	protein coding gene	Chr17:12572096-12592624 (-)
WSB/EiJ	MGP_WSBEiJ_G0022482	protein coding gene	Chr17:13939278-13959590 (-)

Human Ortholog

RGMB, repulsive guidance molecule BMP co-receptor b

Vertebrate Orthologs

10

Human Ortholog

RGMB, repulsive guidance molecule BMP co-receptor b
Orthology source: HomoloGene, HGNC
Synonyms

DRAGON
Links

HGNC:26896

NCBI Gene ID: 285704

neXtProt AC: NX_Q6NW40

UniProt: Q6NW40
Chr Location

5q15; chr5:98768386-98796494 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 65355
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: RGMB
Gene Tree

Rgmb

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Targeted

3
Find Mice (IMSR)

5 strains or lines available

Mice homozygous for a knock-out allele exhibit lethality at 2 to 3 weeks after birth.

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All GO Annotations

15
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

460
Tissues

198
cDNA Data

17
Literature Summary

13

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rgmb

ZFIN rgmb

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Rgmb interacts with 199 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

60
RefSeq

8
UniProt

6
CCDS

CCDS37455.1

Ensembl

ENSMUSG00000048027 (Evidence)
NCBI Gene

68799

			Length	Strain/Species	Flank
genomic	68799	NCBI Gene Model \| MGI Sequence Detail	27157	C57BL/6J	± kb
transcript	NM_178615	RefSeq \| MGI Sequence Detail	2633	Not Specified
polypeptide	Q7TQ33	UniProt \| EBI \| MGI Sequence Detail	436	Not Applicable

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UniProt

6 Sequences
InterPro Domains

IPR016123 Mog1/PsbP, alpha/beta/alpha sandwich

IPR040287 Repulsive guidance molecule

IPR009496 Repulsive guidance molecule, C-terminal

IPR010536 Repulsive guidance molecule, N-terminal

IPR033608 RGM domain family member B

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All nucleic 21

cDNA 18

Primer pair 2

Other 1

Microarray probesets 8

Summaries

All 37

Developmental Gene Expression 13

Gene Ontology 6

Phenotypes 4
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:258289 Liu W, et al., RGMb protects against acute kidney injury by inhibiting tubular cell necroptosis via an MLKL-dependent mechanism. Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1475-E1484

TSS for Rgmb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr146534	Chr17:15826521-15826590 (-)	5,261 bp
Tssr146533	Chr17:15826488-15826512 (-)	5,317 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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