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Rgmb Gene Detail
Summary
  • Symbol
    Rgmb
  • Name
    repulsive guidance molecule family member B
  • Synonyms
    1110059F19Rik, DRAGON, RGM domain family, member B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916049
    NCBI Gene: 68799
  • Gene Overview
    MyGene.info: RGMB
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr17:15806253-15826586 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      20334 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 8.96 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    RGMB, repulsive guidance molecule BMP co-receptor b
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RGMB, repulsive guidance molecule BMP co-receptor b
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DRAGON
  • Links
    NCBI Gene ID: 285704
    neXtProt AC: NX_Q6NW40
    UniProt: Q6NW40

  • Chr Location
    5q15; chr5:98768386-98796494 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 65355
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RGMB
  • Gene Tree
    Rgmb
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit lethality at 2 to 3 weeks after birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    11
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    460
  • Tissues
    198
  • cDNA Data
    16
  • Literature Summary
    13
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000048027 Ensembl Gene Model | MGI Sequence Detail 20334 C57BL/6J ±  kb
transcript ENSMUST00000170578 Ensembl | MGI Sequence Detail 2633 Not Applicable  
polypeptide ENSMUSP00000126177 Ensembl | MGI Sequence Detail 436 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    61 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR016123 Mog1/PsbP, alpha/beta/alpha sandwich
    IPR009496 Repulsive guidance molecule, C-terminal
    IPR010536 Repulsive guidance molecule, N-terminal
    IPR033608 RGM domain family member B
Molecular
Reagents
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  • All nucleic 20
    cDNA 17
    Primer pair 2
    Other 1

    Microarray probesets 8
References
more
  • Summaries
    All 34
    Developmental Gene Expression 13
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:235517 Kam JW, et al., RGMB and neogenin control cell differentiation in the developing olfactory epithelium. Development. 2016 May 1;143(9):1534-46
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/17/2018
MGI 6.11 		The Jackson Laboratory