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Zc3hc1 Gene Detail
Summary
  • Symbol
    Zc3hc1
  • Name
    zinc finger, C3HC type 1
  • Synonyms
    1110054L24Rik, HSPC216, Nipa
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916023
    NCBI Gene: 232679
  • Gene Overview
    MyGene.info: ZC3HC1
Location & Maps
more
  • Sequence Map
    Chr6:30366380-30391028 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24649 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 12.52 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ZC3HC1, zinc finger C3HC-type containing 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ZC3HC1, zinc finger C3HC-type containing 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HSPC216, NIPA
  • Links
    NCBI Gene ID: 51530
    neXtProt AC: NX_Q86WB0

  • Chr Location
    7q32.2; chr7:130018286-130051451 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    46 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Gene trapped
    11
  • Targeted
    4
  • Incidental Mutations
Mice homozygous for a null mutation display partial lethality with male infertility, reduced female fertility, arrest of meiosis, impaired synaptonemal complex formation and delayed double strand DNA break repair.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014349 VEGA Gene Model | MGI Sequence Detail 24649 C57BL/6J ±  kb
transcript OTTMUST00000033905 VEGA | MGI Sequence Detail 1824 Not Applicable  
polypeptide OTTMUSP00000015183 VEGA | MGI Sequence Detail 501 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    83 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000017603 nuclear-interacting partner of ALK
  • InterPro Domains
    IPR013909 Nuclear-interacting partner of ALK/Rsm1-like
    IPR012935 Zinc finger, C3HC-like
Molecular
Reagents
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  • All nucleic 86
    cDNA 86

    Microarray probesets 3
Other
Accession IDs
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MGI:2141556, MGI:2141563
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:185584 Illert AL, et al., Targeted inactivation of nuclear interaction partner of ALK disrupts meiotic prophase. Development. 2012 Jul;139(14):2523-34

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory