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Washc1 Gene Detail
Summary
  • Symbol
    Washc1
  • Name
    WASH complex subunit 1
  • Synonyms
    1110049F14Rik, ORF19, Wash, Wash1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916017
    NCBI Gene: 68767
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:66418540-66427498 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 35.26 cM, cytoband F3-F4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    411 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916017
 protein coding gene Chr17:66418524-66427498 (+)
129S1/SvImJ ENSMUSG00200038467
 protein coding gene Chr17:61767796-61776754 (+)
A/J ENSMUSG00195017041
 protein coding gene Chr17:63110253-63119210 (+)
AKR/J ENSMUSG00220017730
 protein coding gene Chr17:62181802-62190760 (+)
BALB/cJ ENSMUSG00180018785
 protein coding gene Chr17:62847636-62856594 (+)
C3H/HeJ ENSMUSG00175029942
 protein coding gene Chr17:62154955-62163913 (+)
C57BL/6NJ ENSMUSG00215021794
 protein coding gene Chr17:61806675-61815634 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021836
 protein coding gene Chr17:62261547-62270858 (+)
CAST/EiJ ENSTCUG00005025096
 protein coding gene Chr17:62764684-62773774 (+)
CBA/J ENSMUSG00210028614
 protein coding gene Chr17:61954857-61963815 (+)
DBA/2J ENSMUSG00185022459
 protein coding gene Chr17:64799539-64808496 (+)
FVB/NJ ENSMUSG00205017420
 protein coding gene Chr17:62574086-62583044 (+)
JF1/MsJ ENSUMUG00000034814
 protein coding gene Chr17:64440696-64460028 (+)
LP/J ENSMUSG00230013384
 protein coding gene Chr17:65786047-65795005 (+)
NOD/ShiLtJ ENSMUSG00190034328
 protein coding gene Chr17:61933999-61942956 (+)
NZO/HlLtJ ENSMUSG00225025904
 protein coding gene Chr17:68061192-68070149 (+)
PWK/PhJ ENSLUMG00010027897
 protein coding gene Chr17:61725124-61744442 (+)
SPRET/EiJ ENSMSPG00010015670
 protein coding gene Chr17:62090760-62110425 (+)
WSB/EiJ ENSIUOG00005029750
 protein coding gene Chr17:62789841-62798805 (+)



Homology
more
  • Human Ortholog
    WASH2P, WASP family homolog 2, pseudogene
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WASH2P, WASP family homolog 2, pseudogene
  • Synonyms
    FAM39B
  • Links
    NCBI Gene ID: 375260

  • Chr Location
    2q14.1; chr2:113583653-113599037 (+)  GRCh38
  • Human Ortholog
    WASH3P, WASP family homolog 3, pseudogene
  • Synonyms
    FAM39DP
  • Links
    NCBI Gene ID: 374666
    UniProt: C4AMC7

  • Chr Location
    15q26.3; chr15:101960813-101976605 (+)  GRCh38
  • Human Ortholog
    WASH4P, WASP family homolog 4, pseudogene
  • Synonyms
    CXYorf1P, FAM39CP
  • Links
    NCBI Gene ID: 374677

  • Chr Location
    16p13.3; chr16:14081-18091 (-)  GRCh38
  • Human Ortholog
    WASH6P, WASP family homolog 6, pseudogene
  • Synonyms
    CXYorf1, FAM39A, WASH
  • Links
    NCBI Gene ID: 653440
    UniProt: Q9NQA3

  • Chr Location
    XYq28 and Yq12
  • Human Ortholog
    WASHC1, WASH complex subunit 1
  • Synonyms
    FAM39E, WASH, WASH1
  • Links
    NCBI Gene ID: 100287171
    UniProt: A8K0Z3

  • Chr Location
    chr9:14475-73865 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 3 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit lethality prior to E7.5 with increased cell death and autophagy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    67
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    628
  • Tissues
    19
  • cDNA Data
    44
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024101 Ensembl Gene Model | MGI Sequence Detail 8959 C57BL/6J ±  kb
    transcript ENSMUST00000072383 Ensembl | MGI Sequence Detail 2905 Not Applicable  
    polypeptide ENSMUSP00000072220 Ensembl | MGI Sequence Detail 475 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      Genomic 1
      cDNA 44
      Antibodies 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 3
      Gene Ontology 17
      Phenotypes 17
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:390644 Yu J, et al., Defective endomembrane dynamics in Rab27a deficiency impairs nucleic acid sensing and cytokine secretion in immune cells. Cell Rep. 2024 Aug 27;43(8):114598
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory