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Tmem219 Gene Detail
Summary
  • Symbol
    Tmem219
  • Name
    transmembrane protein 219
  • Synonyms
    1110032O16Rik, 2900045G02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915992
    NCBI Gene: 68742
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:126886171-126922917 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 69.25 cM, cytoband F4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    153 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915992
protein coding gene Chr7:126886171-126928683 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033007
protein coding gene Chr7:131192465-131230822 (-)
A/J MGP_AJ_G0032990
protein coding gene Chr7:127712002-127750098 (-)
AKR/J MGP_AKRJ_G0032922
protein coding gene Chr7:130947298-130983708 (-)
BALB/cJ MGP_BALBcJ_G0032995
protein coding gene Chr7:127375521-127413190 (-)
C3H/HeJ MGP_C3HHeJ_G0032705
protein coding gene Chr7:130885460-130923782 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033501
protein coding gene Chr7:136292998-136337812 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030473
protein coding gene Chr7:128905795-128946477 (-)
CAST/EiJ MGP_CASTEiJ_G0032034
protein coding gene Chr7:122671192-122710602 (-)
CBA/J MGP_CBAJ_G0032678
protein coding gene Chr7:140881791-140920476 (-)
DBA/2J MGP_DBA2J_G0032830
protein coding gene Chr7:125687552-125724884 (-)
FVB/NJ MGP_FVBNJ_G0032783
protein coding gene Chr7:125538698-125575230 (-)
LP/J MGP_LPJ_G0032924
protein coding gene Chr7:132658726-132697213 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032815
protein coding gene Chr7:142050617-142092294 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033520
protein coding gene Chr7:129957999-129995801 (-)
PWK/PhJ MGP_PWKPhJ_G0031741
protein coding gene Chr7:118682160-118719409 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031587
protein coding gene Chr7:116802522-116838815 (-)
WSB/EiJ MGP_WSBEiJ_G0032146
protein coding gene Chr7:130936284-130975406 (-)



Homology
more
  • Human Ortholog
    TMEM219, transmembrane protein 219
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TMEM219, transmembrane protein 219
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IGFBP-3R
  • Links
    NCBI Gene ID: 124446
    neXtProt AC: NX_Q86XT9
    UniProt: Q86XT9

  • Chr Location
    16p11.2; chr16:29962030-29973052 (+)  GRCh38.p7

Human Diseases
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  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit attenuated IL13 responsiveness, increased susceptibility to exposure to 100% oxygen, and reduced lung metastasis of B16-F10 melanoma cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000060538 Ensembl Gene Model | MGI Sequence Detail 36747 C57BL/6J ±  kb
transcript ENSMUST00000120007 Ensembl | MGI Sequence Detail 1087 Not Applicable  
polypeptide ENSMUSP00000113647 Ensembl | MGI Sequence Detail 272 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
  • InterPro Domains
    IPR039493 TMEM248/TMEM219
    IPR039587 TMEM248/TMEM219 domain
Molecular
Reagents
less
  • All nucleic 41
    cDNA 41

    Microarray probesets 5
Other
Accession IDs
less
MGI:1920171
References
more
  • Summaries
    All 42
    Diseases 3
    Gene Ontology 1
    Phenotypes 19
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:263550 Wang W, et al., Chemogenetic Activation of Prefrontal Cortex Rescues Synaptic and Behavioral Deficits in a Mouse Model of 16p11.2 Deletion Syndrome. J Neurosci. 2018 Jun 27;38(26):5939-5948

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory