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Acss1 Gene Detail
Summary
  • Symbol
    Acss1
  • Name
    acyl-CoA synthetase short-chain family member 1
  • Synonyms
    1110032O15Rik, Acas2, Acas2l, AceCS2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915988
    NCBI Gene: 68738
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:150460031-150510160 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 74.74 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1445 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915988
 protein coding gene Chr2:150460025-150510420 (-)
129S1/SvImJ ENSMUSG00200026704
 protein coding gene Chr2:147572019-147622176 (-)
A/J ENSMUSG00195020444
 protein coding gene Chr2:147694949-147745116 (-)
AKR/J ENSMUSG00220042306
 protein coding gene Chr2:147051707-147101860 (-)
BALB/cJ ENSMUSG00180039021
 protein coding gene Chr2:147356172-147406342 (-)
C3H/HeJ ENSMUSG00175040449
 protein coding gene Chr2:147903204-147953359 (-)
C57BL/6NJ ENSMUSG00215015039
 protein coding gene Chr2:147427905-147478059 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024425
 protein coding gene Chr2:142693313-142741841 (-)
CAST/EiJ ENSTCUG00005041281
 protein coding gene Chr2:146490412-146540212 (-)
CBA/J ENSMUSG00210036980
 protein coding gene Chr2:147822279-147872441 (-)
DBA/2J ENSMUSG00185047997
 protein coding gene Chr2:147462411-147512578 (-)
FVB/NJ ENSMUSG00205021482
 protein coding gene Chr2:146611049-146661199 (-)
JF1/MsJ ENSUMUG00000042811
 protein coding gene Chr2:147279026-147329010 (-)
LP/J ENSMUSG00230029977
 protein coding gene Chr2:149154434-149204583 (-)
NOD/ShiLtJ ENSMUSG00190034662
 protein coding gene Chr2:147567434-147617380 (-)
NZO/HlLtJ ENSMUSG00225003992
 protein coding gene Chr2:157150554-157200721 (-)
PWK/PhJ ENSLUMG00010036980
 protein coding gene Chr2:147270040-147320245 (-)
SPRET/EiJ ENSMSPG00010023424
 protein coding gene Chr2:149983677-150043445 (-)
WSB/EiJ ENSIUOG00005041175
 protein coding gene Chr2:147198797-147248435 (-)



Homology
more
  • Human Ortholog
    ACSS1, acyl-CoA synthetase short chain family member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACSS1, acyl-CoA synthetase short chain family member 1
  • Synonyms
    ACAS2L, ACECS1, AceCS2L
  • Links
    NCBI Gene ID: 84532
    UniProt: Q9NUB1

  • Chr Location
    20p11.21; chr20:25006230-25058980 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with disruptions in this gene display abnormalities in acetate metabolism. Ability to maintain body temperature under fasting conditions is reduced.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    111
  • cDNA Data
    95
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68738 NCBI Gene Model | MGI Sequence Detail 50130 C57BL/6J ±  kb
    transcript NM_080575 RefSeq | MGI Sequence Detail 3594 C57BL/6  
    polypeptide Q99NB1 UniProt | EBI | MGI Sequence Detail 682 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 96
      cDNA 95
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2139052
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 10
      Gene Ontology 13
      Phenotypes 13
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:390067 Peng F, et al., Acetate enhances neuronal plasticity and reduces ischemic brain injury by promoting tau protein lactylation. J Cereb Blood Flow Metab. 2026 Feb;46(2):493-507
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory