About   Help   FAQ
Acss1 Gene Detail
Summary
  • Symbol
    Acss1
  • Name
    acyl-CoA synthetase short-chain family member 1
  • Synonyms
    1110032O15Rik, Acas2, Acas2l, AceCS2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915988
    NCBI Gene: 68738
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:150618111-150668240 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 74.74 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    258 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915988
protein coding gene Chr2:150618105-150668500 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026628
protein coding gene Chr2:155066432-155120901 (-)
A/J MGP_AJ_G0026595
protein coding gene Chr2:148823405-148874286 (-)
AKR/J MGP_AKRJ_G0026566
protein coding gene Chr2:153145280-153196013 (-)
BALB/cJ MGP_BALBcJ_G0026605
protein coding gene Chr2:149246041-149299827 (-)
C3H/HeJ MGP_C3HHeJ_G0026348
protein coding gene Chr2:153584686-153635075 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027053
protein coding gene Chr2:159599728-159653609 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024425
protein coding gene Chr2:142693313-142741841 (-)
CAST/EiJ MGP_CASTEiJ_G0025808
protein coding gene Chr2:153822608-153876880 (-)
CBA/J MGP_CBAJ_G0026327
protein coding gene Chr2:165451500-165506715 (-)
DBA/2J MGP_DBA2J_G0026461
protein coding gene Chr2:148063125-148114255 (-)
FVB/NJ MGP_FVBNJ_G0026426
protein coding gene Chr2:146523959-146575128 (-)
LP/J MGP_LPJ_G0026565
protein coding gene Chr2:155207009-155257809 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026448
protein coding gene Chr2:169556671-169620289 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027108
protein coding gene Chr2:153083267-153133691 (-)
PWK/PhJ MGP_PWKPhJ_G0025543
protein coding gene Chr2:147697614-147750329 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025345
protein coding gene Chr2:152000835-152059105 (-)
WSB/EiJ MGP_WSBEiJ_G0025881
protein coding gene Chr2:154046513-154099244 (-)



Homology
more
  • Human Ortholog
    ACSS1, acyl-CoA synthetase short chain family member 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ACSS1, acyl-CoA synthetase short chain family member 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACAS2L, ACECS1, AceCS2L
  • Links
    NCBI Gene ID: 84532
    neXtProt AC: NX_Q9NUB1
    UniProt: Q9NUB1

  • Chr Location
    20p11.21; chr20:25006230-25058182 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 56037
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ACSS1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice with disruptions in this gene display abnormalities in acetate metabolism. Ability to maintain body temperature under fasting conditions is reduced.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68738 NCBI Gene Model | MGI Sequence Detail 50130 C57BL/6J ±  kb
    transcript NM_080575 RefSeq | MGI Sequence Detail 3594 C57BL/6  
    polypeptide Q99NB1 UniProt | EBI | MGI Sequence Detail 682 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 96
      cDNA 95
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2139052
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 8
      Gene Ontology 6
      Phenotypes 7
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:240028 Bulusu V, et al., Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Dev Cell. 2017 Feb 27;40(4):331-341.e4

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory