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Ifitm1 Gene Detail
Summary
  • Symbol
    Ifitm1
  • Name
    interferon induced transmembrane protein 1
  • Synonyms
    1110036C17Rik, fragilis2, Mil2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915963
    NCBI Gene: 68713
  • Gene Overview
    MyGene.info: IFITM1
Location & Maps
more
  • Sequence Map
    Chr7:140967221-140969825 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2605 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 86.20 cM, cytoband F5
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    IFITM1, interferon induced transmembrane protein 1
  • Vertebrate Orthologs
    2
  • Human Ortholog
    IFITM1, interferon induced transmembrane protein 1
    Orthology source: HGNC
  • Synonyms
    9-27, CD225, DSPA2a, IFI17, LEU13
  • Links
    NCBI Gene ID: 8519
    neXtProt AC: NX_P13164

  • Chr Location
    11p15.5; chr11:313991-315272 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    66
  • Gene trapped
    60
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Ifitm1
  • Incidental Mutations
Homozygous mutant mice exhibited enhanced motor coordination during inverted screen testing when compared with that of their wild-type littermates.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021113 VEGA Gene Model | MGI Sequence Detail 2605 C57BL/6J ±  kb
transcript OTTMUST00000049966 VEGA | MGI Sequence Detail 882 Not Applicable  
polypeptide OTTMUSP00000023250 VEGA | MGI Sequence Detail 106 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    28 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR007593 CD225/Dispanin family
Molecular
Reagents
less
  • All nucleic 53
    cDNA 49
    Primer pair 4

    Microarray probesets 4
References
more
  • Summaries
    All 39
    Developmental Gene Expression 9
    Gene Ontology 5
    Phenotypes 15
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:199855 Tanaka SS, et al., Dullard/Ctdnep1 modulates WNT signalling activity for the formation of primordial germ cells in the mouse embryo. PLoS One. 2013;8(3):e57428

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory