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Rabl2 Gene Detail
Summary
  • Symbol
    Rabl2
  • Name
    RAB, member RAS oncogene family-like 2
  • Synonyms
    1110031N17Rik, Rabl2a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915958
    NCBI Gene: 68708
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr15:89582533-89591923 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9391 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 44.96 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    RABL2A, RAB, member of RAS oncogene family like 2A
  • Vertebrate Orthologs
    4
  • Human Ortholog
    RABL2A, RAB, member of RAS oncogene family like 2A
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 11159
    neXtProt AC: NX_Q9UBK7
    UniProt: Q9UBK7

  • Chr Location
    2q14.1; chr2:113627218-113643398 (+)  GRCh38.p7

  • Human Ortholog
    RABL2B, RAB, member of RAS oncogene family like 2B
    Orthology source: HGNC
  • Links
    NCBI Gene ID: 11158
    neXtProt AC: NX_Q9UNT1
    UniProt: Q9UNT1

  • Chr Location
    22q13.33; chr22:50767492-50783705 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit male infertility, reduced testis weight, oligospermia, asthenozoospermia and short flagellum.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000035204 VEGA Gene Model | MGI Sequence Detail 9391 C57BL/6J ±  kb
    transcript OTTMUST00000089659 VEGA | MGI Sequence Detail 1640 Not Applicable  
    polypeptide OTTMUSP00000049018 VEGA | MGI Sequence Detail 223 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      133 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • InterPro Domains
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR001806 Small GTPase superfamily
      IPR005225 Small GTP-binding protein domain
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 32

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2139382
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 4
      Phenotypes 29
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:248444 Kanie T, et al., The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base. Dev Cell. 2017 Jul 10;42(1):22-36.e12

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    06/05/2018
    MGI 6.12
    The Jackson Laboratory