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Slc44a2 Gene Detail
Summary
  • Symbol
    Slc44a2
  • Name
    solute carrier family 44, member 2
  • Synonyms
    1110028E10Rik, CTL2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915932
    NCBI Gene: 68682
  • Gene Overview
    MyGene.info: SLC44A2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:21320719-21355028 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34310 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 7.77 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SLC44A2, solute carrier family 44 member 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SLC44A2, solute carrier family 44 member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CTL2, PP1292
  • Links
    NCBI Gene ID: 57153
    neXtProt AC: NX_Q8IWA5
    UniProt: Q8IWA5

  • Chr Location
    19p13.2; chr19:10602445-10644559 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit cochlear hair cell loss, spiral ganglion degeneration, and progressive sensorineural hearing loss.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 68682 NCBI Gene Model | MGI Sequence Detail 34310 C57BL/6J ±  kb
transcript NM_152808 RefSeq | MGI Sequence Detail 3473 C57BL/6  
polypeptide Q8BY89 UniProt | EBI | MGI Sequence Detail 706 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    64 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 14
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:239440 Kommareddi P, et al., Hair Cell Loss, Spiral Ganglion Degeneration, and Progressive Sensorineural Hearing Loss in Mice with Targeted Deletion of Slc44a2/Ctl2. J Assoc Res Otolaryngol. 2015 Dec;16(6):695-712

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory