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Smtnl1
Gene Detail
 Symbol
Name
ID
Smtnl1
smoothelin-like 1
MGI:1915928
Synonyms 1110030K22Rik, Chasm
Feature Type protein coding gene
Genetic Map
Chromosome 2
49.45 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:84811176-84822652 bp, - strand
From VEGA annotation of GRCm38

  11477 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11488  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Smtnl1

Human
homologs
Human Homolog SMTNL1, smoothelin-like 1
NCBI Gene ID 219537
neXtProt AC  NX_A8MU46
Human Synonyms  CHASM
Human Chr (Location)  11q12.1; chr11:57537571-57550274 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(3) Targeted(6)
Genomic Mutations involving Smtnl1 (2)
Incidental mutations (data from APF )
 
Mice homozygous for a null allele exhibit vascular and muscular adaptations normally found in exercised animals as well as increased exercise endurance.
 
Interactions
Smtnl1 interacts with 35 markers (Mir92-1, Mir96, Mir129-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process muscle organ morphogenesis, negative regulation of catalytic activity, ...
Component contractile fiber, cytoplasm, ...
Function calmodulin binding, myosin phosphatase regulator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(5) cDNA(5)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000013726 (Evidence)
Ensembl Gene ModelENSMUSG00000027077 (Evidence)
Entrez Gene68678 (Evidence)
UniGene33452
DFCITC1589097
DoTSDT.60104088
NIA Mouse Gene IndexU022818
PDB2K3S, 2JV9
Consensus CDS ProjectCCDS16195.1
International Mouse Knockout Project StatusSmtnl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013726 VEGA Gene Model | MGI Sequence Detail 11477 C57BL/6J ±  kb
transcript OTTMUST00000032890 VEGA | MGI Sequence Detail 1761 Not Applicable 
polypeptide OTTMUSP00000014696 VEGA | MGI Sequence Detail 459 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(8) UniProt(2)
Polymorphisms SNPs within 2kb(133 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001715 Calponin homology domain
Protein Ontology PR:000015303 smoothelin-like protein 1
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:178379 Richard AF, et al., Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression. Dev Biol. 2011 Nov 15;359(2):303-20
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory