Smtnl1 MGI Mouse Gene Detail - MGI:1915928

Symbol

Smtnl1
Name

smoothelin-like 1
Synonyms

1110030K22Rik, Chasm

Feature Type

protein coding gene
IDs

MGI:1915928
NCBI Gene: 68678
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr2:84641520-84652996 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 49.45 cM, cytoband E1
Mapping Data

2 experiments

SNPs within 2kb

132 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915928	protein coding gene	Chr2:84641494-84657173 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025912	protein coding gene	Chr2:85508915-85520388 (-)
A/J	MGP_AJ_G0025886	protein coding gene	Chr2:82204918-82216578 (-)
AKR/J	MGP_AKRJ_G0025856	protein coding gene	Chr2:84323607-84335264 (-)
BALB/cJ	MGP_BALBcJ_G0025883	protein coding gene	Chr2:82331478-82343429 (-)
C3H/HeJ	MGP_C3HHeJ_G0025642	protein coding gene	Chr2:84562907-84576193 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026329	protein coding gene	Chr2:88158604-88170080 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023731	protein coding gene	Chr2:79021204-79032729 (-)
CAST/EiJ	MGP_CASTEiJ_G0025103	protein coding gene	Chr2:85096172-85107637 (-)
CBA/J	MGP_CBAJ_G0025623	protein coding gene	Chr2:91308918-91323276 (-)
DBA/2J	MGP_DBA2J_G0025754	protein coding gene	Chr2:81736221-81748103 (-)
FVB/NJ	MGP_FVBNJ_G0025717	protein coding gene	Chr2:80991448-81002902 (-)
LP/J	MGP_LPJ_G0025842	protein coding gene	Chr2:85305549-85317215 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025747	protein coding gene	Chr2:93626886-93638340 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026385	protein coding gene	Chr2:84564406-84575864 (-)
PWK/PhJ	MGP_PWKPhJ_G0024847	protein coding gene	Chr2:81580099-81591954 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024651	protein coding gene	Chr2:84701701-84713097 (-)
WSB/EiJ	MGP_WSBEiJ_G0025173	protein coding gene	Chr2:85223895-85236064 (-)

Human Ortholog

SMTNL1, smoothelin like 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SMTNL1, smoothelin like 1
Synonyms

CHASM
Links

HGNC:32394

NCBI Gene ID: 219537

neXtProt AC: NX_A8MU46

UniProt: A8MU46
Chr Location

11q12.1; chr11:57537595-57550272 (+) GRCh38

MGI Vertebrate Homology

Smtnl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SMTNL1
Gene Tree

Smtnl1

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Targeted

6
Genomic Mutations

3 involving Smtnl1
Incidental Mutations

APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit vascular and muscular adaptations normally found in exercised animals as well as increased exercise endurance.

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All GO Annotations

25
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

757
Tissues

20
cDNA Data

6
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN smtnl1

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All Sequences

31
RefSeq

4
UniProt

2
CCDS

CCDS16195.1

Ensembl

ENSMUSG00000027077 (Evidence)
NCBI Gene

68678

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027077	Ensembl Gene Model \| MGI Sequence Detail	11477	C57BL/6J	± kb
transcript	ENSMUST00000028471	Ensembl \| MGI Sequence Detail	1761	Not Applicable
polypeptide	ENSMUSP00000028471	Ensembl \| MGI Sequence Detail	459	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000015303 smoothelin-like protein 1

(term hierarchy)
PDB

2JV9, 2K3S
InterPro Domains

IPR001715 Calponin homology domain

IPR036872 CH domain superfamily

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All nucleic 6

cDNA 6

Microarray probesets 3

Summaries

All 37

Developmental Gene Expression 2

Gene Ontology 8

Phenotypes 13
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:275288 Turner SR, et al., Smoothelin-like 1 deletion enhances myogenic reactivity of mesenteric arteries with alterations in PKC and myosin phosphatase signaling. Sci Rep. 2019 Jan 24;9(1):481

TSS for Smtnl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr25058	Chr2:84652890-84652937 (-)	82 bp
Tssr25057	Chr2:84652870-84652886 (-)	118 bp
Tssr25056	Chr2:84646452-84646491 (-)	6,524 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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