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Taok2 Gene Detail
Summary
  • Symbol
    Taok2
  • Name
    TAO kinase 2
  • Synonyms
    1110033K02Rik, MAP3K17, mKIAA0881, PSK1, TAO1, TAO2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915919
    NCBI Gene: 381921
  • Gene Overview
    MyGene.info: TAOK2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:126865678-126884703 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 69.25 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    81 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915919
protein coding gene Chr7:126865676-126886296 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033006
protein coding gene Chr7:131172079-131190997 (-)
A/J MGP_AJ_G0032989
protein coding gene Chr7:127691510-127710534 (-)
AKR/J MGP_AKRJ_G0032921
protein coding gene Chr7:130926806-130945830 (-)
BALB/cJ MGP_BALBcJ_G0032994
protein coding gene Chr7:127355013-127374053 (-)
C3H/HeJ MGP_C3HHeJ_G0032704
protein coding gene Chr7:130864966-130883992 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033500
protein coding gene Chr7:136272528-136291530 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030472
protein coding gene Chr7:128885277-128904335 (-)
CAST/EiJ MGP_CASTEiJ_G0032033
protein coding gene Chr7:122650922-122669724 (-)
CBA/J MGP_CBAJ_G0032677
protein coding gene Chr7:140861297-140880323 (-)
DBA/2J MGP_DBA2J_G0032829
protein coding gene Chr7:125667063-125686084 (-)
FVB/NJ MGP_FVBNJ_G0032782
protein coding gene Chr7:125518265-125537230 (-)
LP/J MGP_LPJ_G0032923
protein coding gene Chr7:132638241-132657258 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032814
protein coding gene Chr7:142030128-142049149 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033519
protein coding gene Chr7:129937506-129956531 (-)
PWK/PhJ MGP_PWKPhJ_G0031740
protein coding gene Chr7:118661549-118680692 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031586
protein coding gene Chr7:116782312-116801058 (-)
WSB/EiJ MGP_WSBEiJ_G0032145
protein coding gene Chr7:130915804-130934816 (-)



Homology
more
  • Human Ortholog
    TAOK2, TAO kinase 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TAOK2, TAO kinase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MAP3K17, PSK, PSK1, PSK1-BETA, TAO1, TAO2
  • Links
    NCBI Gene ID: 9344
    neXtProt AC: NX_Q9UL54
    UniProt: Q9UL54

  • Chr Location
    16p11.2; chr16:29973641-29992261 (+)  GRCh38.p7

Human Diseases
less
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 3 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruption exhibit decreased body size. Mice homozygous for a targeted allele exhibit resistance to the ataxic effect of alcohol, reduced blood ethanol content, increased alcohol consumption, impaired CPP for alcohol, and impaired habituation in an open field.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059981 Ensembl Gene Model | MGI Sequence Detail 19026 C57BL/6J ±  kb
    transcript ENSMUST00000117394 Ensembl | MGI Sequence Detail 4985 Not Applicable  
    polypeptide ENSMUSP00000112963 Ensembl | MGI Sequence Detail 1240 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 59
      Genomic 2
      cDNA 57

      Microarray probesets 4
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 3
      Diseases 3
      Gene Ontology 7
      Phenotypes 19
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:263550 Wang W, et al., Chemogenetic Activation of Prefrontal Cortex Rescues Synaptic and Behavioral Deficits in a Mouse Model of 16p11.2 Deletion Syndrome. J Neurosci. 2018 Jun 27;38(26):5939-5948

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory