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Klk5 Gene Detail
Summary
  • Symbol
    Klk5
  • Name
    kallikrein related-peptidase 5
  • Synonyms
    1110030O19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915918
    NCBI Gene: 68668
  • Gene Overview
    MyGene.info: KLK5
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:43841971-43851181 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 28.30 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    207 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915918
protein coding gene Chr7:43834157-43851181 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032146
protein coding gene Chr7:43893890-43903325 (+)
A/J MGP_AJ_G0032131
protein coding gene Chr7:42973197-42984842 (+)
AKR/J MGP_AKRJ_G0032061
protein coding gene Chr7:44359543-44370906 (+)
BALB/cJ MGP_BALBcJ_G0032136
protein coding gene Chr7:43089328-43098484 (+)
C3H/HeJ MGP_C3HHeJ_G0031852
protein coding gene Chr7:44868444-44878922 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032620
protein coding gene Chr7:46101850-46111024 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029643
protein coding gene Chr7:45105607-45114444 (+)
CAST/EiJ MGP_CASTEiJ_G0031182
protein coding gene Chr7:36057779-36066941 (+)
CBA/J MGP_CBAJ_G0031821
protein coding gene Chr7:47563058-47572378 (+)
DBA/2J MGP_DBA2J_G0031970
protein coding gene Chr7:42779072-42788613 (+)
FVB/NJ MGP_FVBNJ_G0031931
protein coding gene Chr7:42490202-42499641 (+)
LP/J MGP_LPJ_G0032049
protein coding gene Chr7:44613447-44625447 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031967
protein coding gene Chr7:46486291-46498341 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032640
protein coding gene Chr7:43487164-43497556 (+)
PWK/PhJ MGP_PWKPhJ_G0030903
protein coding gene Chr7:36230209-36239829 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030742
protein coding gene Chr7:31517762-31528520 (+)
WSB/EiJ MGP_WSBEiJ_G0031296
protein coding gene Chr7:44034566-44043751 (+)



Homology
more
  • Human Ortholog
    KLK5, kallikrein related peptidase 5
  • Vertebrate Orthologs
    7
  • Human Ortholog
    KLK5, kallikrein related peptidase 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KLKL2, KLK-L2, SCTE
  • Links
    NCBI Gene ID: 25818
    neXtProt AC: NX_Q9Y337
    UniProt: Q9Y337

  • Chr Location
    19q13.41; chr19:50943299-50953088 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from multigenic genotypes
    8 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000074155 Ensembl Gene Model | MGI Sequence Detail 9211 C57BL/6J ±  kb
transcript ENSMUST00000048444 Ensembl | MGI Sequence Detail 1239 Not Applicable  
polypeptide ENSMUSP00000049339 Ensembl | MGI Sequence Detail 293 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR001314 Peptidase S1A, chymotrypsin family
    IPR009003 Peptidase S1, PA clan
    IPR001254 Serine proteases, trypsin domain
    IPR018114 Serine proteases, trypsin family, histidine active site
    IPR033116 Serine proteases, trypsin family, serine active site
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 3
References
more
  • Summaries
    All 30
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:238698 Kasparek P, et al., KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype. PLoS Genet. 2017 Jan;13(1):e1006566

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory