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Slc25a25 Gene Detail
Summary
  • Symbol
    Slc25a25
  • Name
    solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25
  • Synonyms
    1110030N17Rik, mKIAA1896
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915913
    NCBI Gene: 227731
Location & Maps
more
  • Sequence Map
    Chr2:32414487-32451445 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      36959 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 22.09 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SLC25A25, solute carrier family 25 member 25
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC25A25, solute carrier family 25 member 25
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MCSC, PCSCL, SCAMC-2
  • Links
    NCBI Gene ID: 114789
    neXtProt AC: NX_Q6KCM7

  • Chr Location
    9q34.11; chr9:128068200-128109258 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Gene trapped
    10
  • Targeted
    5
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit reduced physical endurance and metabolic efficiency.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011993 VEGA Gene Model | MGI Sequence Detail 36959 C57BL/6J ±  kb
transcript OTTMUST00000028394 VEGA | MGI Sequence Detail 3294 Not Applicable  
polypeptide OTTMUSP00000012866 VEGA | MGI Sequence Detail 514 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    115 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000015021 calcium-binding mitochondrial carrier protein SCaMC-2
  • InterPro Domains
    IPR002048 EF-hand domain
    IPR011992 EF-hand domain pair
    IPR002167 Graves disease carrier protein
    IPR023395 Mitochondrial carrier domain
    IPR002067 Mitochondrial carrier protein
    IPR018108 Mitochondrial substrate/solute carrier
Molecular
Reagents
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  • All nucleic 13
    cDNA 12
    Primer pair 1

    Microarray probesets 6
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:196890 Amigo I, et al., Glucagon regulation of oxidative phosphorylation requires an increase in matrix adenine nucleotide content through Ca2+ activation of the mitochondrial ATP-Mg/Pi carrier SCaMC-3. J Biol Chem. 2013 Mar 15;288(11):7791-802

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory