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Nadk2 Gene Detail
Summary
  • Symbol
    Nadk2
  • Name
    NAD kinase 2, mitochondrial
  • Synonyms
    1110020G09Rik, 4933430B08Rik, MNADK, Nadkd1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915896
    NCBI Gene: 68646
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:9071260-9110496 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 3.82 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    107 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915896
 protein coding gene Chr15:9071260-9110891 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021710
 protein coding gene Chr15:6148766-6193637 (+)
A/J MGP_AJ_G0021670
 protein coding gene Chr15:5983863-6027548 (+)
AKR/J MGP_AKRJ_G0021648
 protein coding gene Chr15:6046344-6085725 (+)
BALB/cJ MGP_BALBcJ_G0021677
 protein coding gene Chr15:5895256-5936230 (+)
C3H/HeJ MGP_C3HHeJ_G0021453
 protein coding gene Chr15:6096335-6136936 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022116
 protein coding gene Chr15:6359863-6405137 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019653
 protein coding gene Chr15:5552579-5593453 (+)
CAST/EiJ MGP_CASTEiJ_G0020969
 protein coding gene Chr15:6098027-6142810 (+)
CBA/J MGP_CBAJ_G0021422
 protein coding gene Chr15:6507493-6548718 (+)
DBA/2J MGP_DBA2J_G0021546
 protein coding gene Chr15:5869199-5908251 (+)
FVB/NJ MGP_FVBNJ_G0021524
 protein coding gene Chr15:5791982-5834349 (+)
LP/J MGP_LPJ_G0021614
 protein coding gene Chr15:6072936-6116019 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021549
 protein coding gene Chr15:6749233-6797208 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022139
 protein coding gene Chr15:6104431-6146433 (+)
PWK/PhJ MGP_PWKPhJ_G0020712
 protein coding gene Chr15:5919941-5967557 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020550
 protein coding gene Chr15:5975348-6020987 (+)
WSB/EiJ MGP_WSBEiJ_G0021025
 protein coding gene Chr15:6036213-6077065 (+)



Homology
more
  • Human Ortholog
    NADK2, NAD kinase 2, mitochondrial
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NADK2, NAD kinase 2, mitochondrial
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C5orf33, DECRD, MNADK, NADKD1
  • Links
    NCBI Gene ID: 133686
    neXtProt AC: NX_Q4G0N4
    UniProt: Q4G0N4

  • Chr Location
    5p13.2; chr5:36192589-36242279 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 3 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for knock-out allele exhibit increased serum lysine and carnitine levels, develop increased reactive oxygen species levels and hepatic steatosis on an atherogenic high-fat diet, and show impaired fasting-induced fatty acid oxidation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
    13
  • Literature Summary
    1
Interactions
less
Sequences &
Gene Models
less
  • All Sequences
    69
  • RefSeq
    9
  • UniProt
    5
Representative SequencesLengthStrain/SpeciesFlank
genomic 68646 NCBI Gene Model | MGI Sequence Detail 39237 C57BL/6J ±  kb
transcript NM_001085410 RefSeq | MGI Sequence Detail 3740 C57BL/6  
polypeptide Q8C5H8 UniProt | EBI | MGI Sequence Detail 452 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 13

    Microarray probesets 7
Other
Accession IDs
less
MGI:1918451
References
more
  • Summaries
    All 35
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:261316 Perez-Garcia V, et al., Placentation defects are highly prevalent in embryonic lethal mouse mutants. Nature. 2018 Mar 22;555(7697):463-468
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/10/2019
MGI 6.14 		The Jackson Laboratory