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Smyd2
Gene Detail
Symbol

Name
ID
Smyd2
SET and MYND domain containing 2
MGI:1915889
Synonyms
1110020E07Rik, KMT3C, Zmynd14
Feature Type
protein coding gene
Genetic Map
Chromosome 1
95.03 cM, cytoband H6
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:189880492-189922363 bp, - strand
From VEGA annotation of GRCm38

  41872 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32466  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SMYD2
Protein SuperFamily: protein methyltransferase, HSKM-B type
Gene Tree: Smyd2

Human
homologs
SMYD2, SET and MYND domain containing 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 56950
neXtProt AC: NX_Q9NRG4

Human Synonyms: HSKM-B, KMT3C, ZMYND14

Human Chr (Location): 1q32.3; chr1:214281222-214337134 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(101) : Gene trapped(97) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted allele exhibit increased circulating total and LDL cholesterol levels and decreased circulating sodium and chloride levels.
 
Interactions
Smyd2 interacts with 39 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (89 annotations)
Process chromatin modification, histone H3-K36 methylation, ...
Component cytoplasm, cytosol, ...
Function 1-hydroxy-6-methoxypyrene methyltransferase activity, 1-hydroxypyrene methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (109)    Tissues (26)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 99
Northern blot 10
cDNA source data(79)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100495522 ; ZFIN smyd2a, smyd2b    NEW 
Molecular
reagents
All nucleic(79) cDNA(79)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000017096 (Evidence)
Ensembl Gene Model ENSMUSG00000026603 (Evidence)
Entrez Gene 226830 (Evidence)
UniGene 156895
DFCI TC1576137, TC1603676
DoTS DT.101137184, DT.94211645, DT.101384146, DT.493253
NIA Mouse Gene Index U022192
EC 2.1.1.-, 2.1.1.43
PDB 3QWV, 3QWW
Consensus CDS Project CCDS35821.1
International Mouse Phenotyping Consortium Status Smyd2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017096 VEGA Gene Model | MGI Sequence Detail 41872 C57BL/6J ±  kb
transcript OTTMUST00000041402 VEGA | MGI Sequence Detail 1680 Not Applicable 
polypeptide OTTMUSP00000018575 VEGA | MGI Sequence Detail 433 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(9) UniProt(2)
Polymorphisms
SNPs within 2kb(165 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001214 SET domain
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR002893 Zinc finger, MYND-type
Protein Ontology PR:000032260 N-lysine methyltransferase SMYD2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:218492 Sajjad A, et al., Lysine methyltransferase Smyd2 suppresses p53-dependent cardiomyocyte apoptosis. Biochim Biophys Acta. 2014 Nov;1843(11):2556-62
All references(40)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory