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Smyd2
Gene Detail
 Symbol
Name
ID
Smyd2
SET and MYND domain containing 2
MGI:1915889
Synonyms 1110020E07Rik, KMT3C, Zmynd14
Feature Type protein coding gene
Genetic Map
Chromosome 1
95.03 cM, cytoband H6
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:189880492-189922363 bp, - strand
From VEGA annotation of GRCm38

  41872 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32466  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: protein methyltransferase, HSKM-B type
Gene Tree: Smyd2

Human
homologs
Human Homolog SMYD2, SET and MYND domain containing 2
NCBI Gene ID 56950
neXtProt AC  NX_Q9NRG4
Human Synonyms  HSKM-B, KMT3C, ZMYND14
Human Chr (Location)  1q32.3; chr1:214281222-214337134 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(149) : Gene trapped(145) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted allele exhibit increased circulating total and LDL cholesterol levels and decreased circulating sodium and chloride levels.
 
Interactions
Smyd2 interacts with 40 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (86 annotations)
Process chromatin modification, histone H3-K36 methylation, ...
Component cytoplasm, cytosol, ...
Function 1-hydroxy-6-methoxypyrene methyltransferase activity, 1-hydroxypyrene methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (109)    Tissues (26)    Images (23)
Theiler Stages: 21, 22, 23, 28
Assay TypeResults
RNA in situ 99
Northern blot 10
cDNA source data(79)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(79) cDNA(79)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000017096 (Evidence)
Ensembl Gene ModelENSMUSG00000026603 (Evidence)
Entrez Gene226830 (Evidence)
UniGene156895
DFCITC1576137, TC1603676
DoTSDT.101137184, DT.101384146, DT.493253, DT.94211645
NIA Mouse Gene IndexU022192
EC2.1.1.-, 2.1.1.43
PDB3QWV, 3QWW
Consensus CDS ProjectCCDS35821.1
International Mouse Knockout Project StatusSmyd2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017096 VEGA Gene Model | MGI Sequence Detail 41872 C57BL/6J ±  kb
transcript OTTMUST00000041402 VEGA | MGI Sequence Detail 1680 Not Applicable 
polypeptide OTTMUSP00000018575 VEGA | MGI Sequence Detail 433 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(9) UniProt(2)
Polymorphisms SNPs within 2kb(165 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001214 SET domain
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR002893 Zinc finger, MYND-type
Protein Ontology PR:000032260 N-lysine methyltransferase SMYD2
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:198873 Voelkel T, et al., Lysine methyltransferase Smyd2 regulates Hsp90-mediated protection of the sarcomeric titin springs and cardiac function. Biochim Biophys Acta. 2013 Apr;1833(4):812-22
All references(41)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory