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Mthfd2l Gene Detail
Summary
  • Symbol
    Mthfd2l
  • Name
    methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
  • Synonyms
    1110019K23Rik, C630010D07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915871
    NCBI Gene: 665563
Location & Maps
more
  • Sequence Map
    Chr5:90931117-91021368 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      90252 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 44.78 cM, cytoband E2
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MTHFD2L, methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MTHFD2L, methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 441024
    neXtProt AC: NX_Q9H903

  • Chr Location
    4q13.3; chr4:74114183-74303099 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    4
  • Genomic Mutations
    4 involving Mthfd2l
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055511 VEGA Gene Model | MGI Sequence Detail 90252 C57BL/6J ±  kb
transcript OTTMUST00000137395 VEGA | MGI Sequence Detail 2159 Not Applicable  
polypeptide OTTMUSP00000072369 VEGA | MGI Sequence Detail 338 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    758 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000030938 bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2
  • EC
  • InterPro Domains
    IPR016040 NAD(P)-binding domain
    IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase
    IPR020630 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
    IPR020867 Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site
    IPR020631 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
Molecular
Reagents
less
  • All nucleic 27
    cDNA 27

    Microarray probesets 7
Other
Accession IDs
less
MGI:3529335
References
more
  • Summaries
    All 33
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:214110 Shin M, et al., Mitochondrial MTHFD2L is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase expressed in both adult and embryonic tissues. J Biol Chem. 2014 May 30;289(22):15507-17

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory