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Qars Gene Detail
Summary
  • Symbol
    Qars
  • Name
    glutaminyl-tRNA synthetase
  • Synonyms
    1110018N24Rik, 1200016L19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915851
    NCBI Gene: 97541
  • Gene Overview
    MyGene.info: QARS
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:108508005-108515941 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 59.44 cM, cytoband F2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    15 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915851
protein coding gene Chr9:108507706-108515941 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035302
protein coding gene Chr9:110468725-110476953 (+)
A/J MGP_AJ_G0035281
protein coding gene Chr9:106420407-106428635 (+)
AKR/J MGP_AKRJ_G0035213
protein coding gene Chr9:109083883-109092111 (+)
BALB/cJ MGP_BALBcJ_G0035275
protein coding gene Chr9:106117684-106125912 (+)
C3H/HeJ MGP_C3HHeJ_G0034985
protein coding gene Chr9:109474074-109483206 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035795
protein coding gene Chr9:113483196-113491424 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032693
protein coding gene Chr9:103852119-103860198 (+)
CAST/EiJ MGP_CASTEiJ_G0034296
protein coding gene Chr9:109444560-109453470 (+)
CBA/J MGP_CBAJ_G0034953
protein coding gene Chr9:117477598-117485744 (+)
DBA/2J MGP_DBA2J_G0035114
protein coding gene Chr9:105872688-105880916 (+)
FVB/NJ MGP_FVBNJ_G0035062
protein coding gene Chr9:104641645-104650187 (+)
LP/J MGP_LPJ_G0035190
protein coding gene Chr9:110662356-110670584 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035101
protein coding gene Chr9:119055909-119064137 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035816
protein coding gene Chr9:109369701-109377929 (+)
PWK/PhJ MGP_PWKPhJ_G0034003
protein coding gene Chr9:106206611-106214861 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033838
protein coding gene Chr9:109423723-109431841 (+)
WSB/EiJ MGP_WSBEiJ_G0034417
protein coding gene Chr9:109253431-109261659 (+)



Homology
more
  • Human Ortholog
    QARS, glutaminyl-tRNA synthetase
  • Vertebrate Orthologs
    2
  • Human Ortholog
    QARS, glutaminyl-tRNA synthetase
    Orthology source: HGNC
  • Synonyms
    GLNRS, MSCCA, PRO2195
  • Links
    NCBI Gene ID: 5859
    neXtProt AC: NX_P47897
    UniProt: P47897

  • Chr Location
    3p21.31; chr3:49095932-49105129 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 97541 NCBI Gene Model | MGI Sequence Detail 7937 C57BL/6J ±  kb
transcript NM_133794 RefSeq | MGI Sequence Detail 2501 C57BL/6  
polypeptide Q8BML9 UniProt | EBI | MGI Sequence Detail 775 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    20 Sequences
  • EC
  • InterPro Domains
    IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
    IPR004514 Glutamine-tRNA synthetase
    IPR007638 Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain 2
    IPR007639 Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal
    IPR000924 Glutamyl/glutaminyl-tRNA synthetase
    IPR020059 Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain
    IPR020058 Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain
    IPR011035 Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain superfamily
    IPR020056 Ribosomal protein L25/Gln-tRNA synthetase, N-terminal
    IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
Molecular
Reagents
less
  • All nucleic 285
    cDNA 284
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1918980, MGI:2143413
References
more
  • Summaries
    All 36
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:227872 Zhang X, et al., Mutations in QARS, encoding glutaminyl-tRNA synthetase, cause progressive microcephaly, cerebral-cerebellar atrophy, and intractable seizures. Am J Hum Genet. 2014 Apr 3;94(4):547-58

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory