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Syf2
Gene Detail
Symbol

Name
ID
Syf2
SYF2 homolog, RNA splicing factor (S. cerevisiae)
MGI:1915842
Synonyms
1110018L13Rik, Cbpin, D4Bwg1551e, Gcipip, mp29, Ntc31, p29
Feature Type
protein coding gene
Genetic Map
Chromosome 4
67.15 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:134930898-134937548 bp, + strand
From VEGA annotation of GRCm38

  6651 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5993  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SYF2
Protein SuperFamily: pre-mRNA splicing factor SYF2
Gene Tree: Syf2

Human
homologs
SYF2, SYF2 pre-mRNA-splicing factor
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 25949
neXtProt AC: NX_O95926

Human Synonyms: CBPIN, fSAP29, NTC31, P29

Human Chr (Location): 1p36.11; chr1:25222276-25232522 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(3) Targeted(4)
Genomic Mutations involving Syf2 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a gene trapped allele fail to undergo normal gastrulation and exhibit complete embryonic lethality, severely impaired embryonic development, and abnormal cell cycle checkpoint function.
 
Phenotype Images(1)
Interactions
Syf2 interacts with 110 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process embryonic organ development, gastrulation, ...
Component catalytic step 1 spliceosome, catalytic step 2 spliceosome, ...
Function poly(A) RNA binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(133)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase syf2 ; ZFIN syf2    NEW 
Molecular
reagents
All nucleic(134) cDNA(133) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000011091 (Evidence)
Ensembl Gene Model ENSMUSG00000028821 (Evidence)
Entrez Gene 68592 (Evidence)
UniGene 29989
DFCI TC1574311
DoTS DT.103556908, DT.495283
NIA Mouse Gene Index U004943
Consensus CDS Project CCDS18781.1
International Mouse Phenotyping Consortium Status Syf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011091 VEGA Gene Model | MGI Sequence Detail 6651 C57BL/6J ±  kb
transcript OTTMUST00000025956 VEGA | MGI Sequence Detail 1369 Not Applicable 
polypeptide OTTMUSP00000011890 VEGA | MGI Sequence Detail 242 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(53 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013260 mRNA splicing factor SYF2
Protein Ontology PR:000015868 pre-mRNA-splicing factor SYF2
References
(Earliest) J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
(Latest) J:187030 Chen CH, et al., Disruption of murine mp29/Syf2/Ntc31 gene results in embryonic lethality with aberrant checkpoint response. PLoS One. 2012;7(3):e33538
All references(36)
Other
accession IDs
MGD-MRK-35798, MGI:107332

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory