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Tmed10 Gene Detail
Summary
  • Symbol
    Tmed10
  • Name
    transmembrane emp24-like trafficking protein 10 (yeast)
  • Synonyms
    1110014C03Rik, p23, p24delta1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915831
    NCBI Gene: 68581
  • Gene Overview
    MyGene.info: TMED10
Location & Maps
more
  • Sequence Map
    Chr12:85340614-85374717 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34104 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 39.65 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    TMED10, transmembrane p24 trafficking protein 10
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TMED10, transmembrane p24 trafficking protein 10
    Orthology source: HomoloGene, HGNC
  • Synonyms
    p23, p24d1, P24(DELTA), S31I125, S31III125, TMP21, Tmp-21-I
  • Links
    NCBI Gene ID: 10972
    neXtProt AC: NX_P49755

  • Chr Location
    14q24.3; chr14:75131468-75176646 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4972
    1 human;2 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: TMED10
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    91
  • Chemically induced (other)
    1
  • Gene trapped
    85
  • Targeted
    5
  • Genomic Mutations
    1 involving Tmed10
  • Incidental Mutations
Mice homozygous for a null mutation display embryonic lethality before implantation. Heterozygous mice display abnormalities of the Golgi apparatus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 68581 NCBI Gene Model | MGI Sequence Detail 34104 C57BL/6J ±  kb
transcript NM_026775 RefSeq | MGI Sequence Detail 3526 C57BL/6  
polypeptide Q9D1D4 UniProt | EBI | MGI Sequence Detail 219 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    140 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000016402 transmembrane emp24 domain-containing protein 10
  • InterPro Domains
    IPR009038 GOLD domain
    IPR015720 TMP21-related
Molecular
Reagents
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  • All nucleic 11
    cDNA 10
    Primer pair 1

    Microarray probesets 6
References
more
  • Summaries
    All 39
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 16
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:221387 Liu L, et al., Pre-synaptic localization of the gamma-secretase-inhibiting protein p24alpha2 in the mammalian brain. J Neurochem. 2015 May;133(3):422-31

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory