Caly
Gene Detail

Symbol Name ID

Caly calcyon neuron-specific vesicular protein MGI:1915816

Synonyms

0710001P07Rik, 1110004A22Rik, Calcyon, Drd1ip

Feature Type

protein coding gene

Genetic Map

Chromosome 7

85.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr7:140069880-140082548 bp, - strand From NCBI annotation of GRCm38   12669 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:9256  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: neuron specific protein/calcyon
Gene Tree: Caly

Human homologs

Human Homolog		CALY, calcyon neuron-specific vesicular protein
NCBI Gene ID		50632
neXtProt AC		NX_Q9NYX4
Human Synonyms		DRD1IP, NSG3
Human Chr (Location)		10q26.3; chr10:133325424-133336971 (-)  GRCh38

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Neurons in homozygous null mice have defects in clathrin-mediated endocytosis (CME) that manifests as an absence of long term depression in post-synaptic currents of the hippocampus.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	clathrin coat assembly, dopamine receptor signaling pathway, ...
Component	cytoplasmic vesicle, integral component of membrane, ...
Function	clathrin light chain binding, protein complex binding

External Resources: FuncBase

Expression

Literature Summary: (2 records)

Data Summary: Results (199)    Tissues (28)    Images (24)
Theiler Stages: 23

Assay Type	Results
RNA in situ	199

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) cDNA(16)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000025468 (Evidence)
Entrez Gene	68566 (Evidence)
UniGene	44241
DFCI	TC1584185, TC1592222, TC1592329
DoTS	DT.101146574, DT.101360351, DT.527742, DT.94289218
NIA Mouse Gene Index	U029418
Consensus CDS Project	CCDS21962.1
International Mouse Knockout Project Status	Caly

Sequences

Length	Strain/Species
genomic	68566	NCBI Gene Model | MGI Sequence Detail	12669	C57BL/6J
transcript	NM_001190386	RefSeq | MGI Sequence Detail	1262	C57BL/6
polypeptide	Q9DCA7	UniProt | EBI | MGI Sequence Detail	226	Not Applicable

All sequences(33) RefSeq(12) UniProt(1)

Polymorphisms

SNPs within 2kb(55 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR009431	Calcyon neuron-specific vesicular protein
Protein Ontology	PR:000004987	neuron-specific vesicular protein calcyon

Graphical View of Protein Domain Structure

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:197462 Dillman AA, et al., mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex. Nat Neurosci. 2013 Apr;16(4):499-506
All references(32)

Other accession IDs

MGI:1923521