Caly MGI Mouse Gene Detail - MGI:1915816 - calcyon neuron-specific vesicular protein

Symbol

Caly
Name

calcyon neuron-specific vesicular protein
Synonyms

0710001P07Rik, 1110004A22Rik, Calcyon, Drd1ip

Feature Type

protein coding gene
IDs

MGI:1915816
NCBI Gene: 68566
Gene Overview

MyGene.info: CALY
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr7:140069880-140082548 bp, - strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 85.07 cM
Mapping Data

1 experiment

SNPs within 2kb

55 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915816	protein coding gene	Chr7:140069880-140082569 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033161	protein coding gene	Chr7:145147718-145160386 (-)
A/J	MGP_AJ_G0033143	protein coding gene	Chr7:141020128-141032803 (-)
AKR/J	MGP_AKRJ_G0033075	protein coding gene	Chr7:144856324-144868974 (-)
BALB/cJ	MGP_BALBcJ_G0033144	protein coding gene	Chr7:140750992-140763651 (-)
C3H/HeJ	MGP_C3HHeJ_G0032858	protein coding gene	Chr7:144664415-144677083 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033655	protein coding gene	Chr7:150486909-150499569 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030628	protein coding gene	Chr7:142141272-142154065 (-)
CAST/EiJ	MGP_CASTEiJ_G0032188	protein coding gene	Chr7:136959262-136973610 (-)
CBA/J	MGP_CBAJ_G0032831	protein coding gene	Chr7:155550870-155566391 (-)
DBA/2J	MGP_DBA2J_G0032983	protein coding gene	Chr7:138981062-138993738 (-)
FVB/NJ	MGP_FVBNJ_G0032936	protein coding gene	Chr7:138869766-138882446 (-)
LP/J	MGP_LPJ_G0033077	protein coding gene	Chr7:146689933-146702587 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032968	protein coding gene	Chr7:156217619-156230378 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033675	protein coding gene	Chr7:143863498-143876166 (-)
PWK/PhJ	MGP_PWKPhJ_G0031894	protein coding gene	Chr7:132162905-132176031 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031739	protein coding gene	Chr7:130697234-130711559 (-)
WSB/EiJ	MGP_WSBEiJ_G0032299	protein coding gene	Chr7:144755012-144767778 (-)

Human Ortholog

CALY, calcyon neuron specific vesicular protein

Vertebrate Orthologs

7

Human Ortholog

CALY, calcyon neuron specific vesicular protein
Orthology source: HomoloGene, HGNC
Synonyms

DRD1IP, NSG3
Links

HGNC:17938

NCBI Gene ID: 50632

neXtProt AC: NX_Q9NYX4

UniProt: Q9NYX4
Chr Location

10q26.3; chr10:133325423-133336983 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 9256
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 macaque, rhesus
HCOP

human homology predictions: CALY
Protein SuperFamily

neuron specific protein/calcyon
Gene Tree

Caly

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Radiation induced

1
Targeted

5
Transgenic

1
Genomic Mutations

1 involving Caly
Incidental Mutations

CvDC
Find Mice (IMSR)

4 strains or lines available

Neurons in homozygous null mice have defects in clathrin-mediated endocytosis (CME) that manifests as an absence of long term depression in post-synaptic currents of the hippocampus.

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All GO Annotations

21
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

199
Tissues

28
cDNA Data

17
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Caly interacts with 67 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

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All Sequences

50
RefSeq

14
UniProt

1
CCDS

CCDS21962.1
UniGene

44241

Ensembl

ENSMUSG00000025468 (Evidence)
NCBI Gene

68566

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025468	Ensembl Gene Model \| MGI Sequence Detail	12669	C57BL/6J	± kb
transcript	ENSMUST00000026541	Ensembl \| MGI Sequence Detail	1220	Not Applicable
polypeptide	ENSMUSP00000026541	Ensembl \| MGI Sequence Detail	226	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000004987 neuron-specific vesicular protein calcyon

(term hierarchy)
InterPro Domains

IPR009431 Neuronal vesicle trafficking-associated protein

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All nucleic 17

cDNA 17

Microarray probesets 2

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MGI:1923521

Summaries

All 34

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 9
Earliest

J:65007 Cattanach BM, et al., Two imprinted gene mutations: three phenotypes. Hum Mol Genet. 2000 Sep 22;9(15):2263-73
Latest

J:197462 Dillman AA, et al., mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex. Nat Neurosci. 2013 Apr;16(4):499-506

TSS for Caly:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr75500	Chr7:140082559-140082570 (-)	-17 bp
Tssr75499	Chr7:140082489-140082556 (-)	25 bp
Tssr75498	Chr7:140082246-140082284 (-)	283 bp
Tssr75497	Chr7:140082222-140082236 (-)	319 bp
Tssr75496	Chr7:140082199-140082201 (-)	348 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/15/2019 MGI 6.14