Caly MGI Mouse Gene Detail - MGI:1915816 - calcyon neuron-specific vesicular protein

Caly Gene Detail

Symbol

Caly
Name

calcyon neuron-specific vesicular protein
Synonyms

0710001P07Rik, 1110004A22Rik, Calcyon, Drd1ip

Feature Type

protein coding gene
IDs

MGI:1915816
NCBI Gene: 68566
Gene Overview

MyGene.info: CALY
Alliance

gene page

Sequence Map

Chr7:140069880-140082548 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

12669 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 85.07 cM
Mapping Data

1 experiment

Human Ortholog

CALY, calcyon neuron specific vesicular protein

Vertebrate Orthologs

7

Human Ortholog

CALY, calcyon neuron specific vesicular protein
Orthology source: HomoloGene, HGNC
Synonyms

DRD1IP, NSG3
Links

HGNC:17938

NCBI Gene ID: 50632

neXtProt AC: NX_Q9NYX4

UniProt: Q9NYX4
Chr Location

10q26.3; chr10:133325423-133336983 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 9256
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 macaque, rhesus
HCOP

human homology predictions: CALY
Protein SuperFamily

neuron specific protein/calcyon
Gene Tree

Caly

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Radiation induced

1
Targeted

5
Transgenic

1
Genomic Mutations

1 involving Caly
Incidental Mutations

CvDC
Find Mice (IMSR)

6 strains or lines available

Neurons in homozygous null mice have defects in clathrin-mediated endocytosis (CME) that manifests as an absence of long term depression in post-synaptic currents of the hippocampus.

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All GO Annotations

15
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

199
Tissues

28
cDNA Data

16
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Caly interacts with 67 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

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All Sequences

42
RefSeq

14
UniProt

1
CCDS

CCDS21962.1
UniGene

44241

			Length	Strain/Species	Flank
genomic	OTTMUSG00000060573	VEGA Gene Model \| MGI Sequence Detail	12669	C57BL/6J	± kb
transcript	OTTMUST00000148178	VEGA \| MGI Sequence Detail	1220	Not Applicable
polypeptide	OTTMUSP00000077056	VEGA \| MGI Sequence Detail	226	Not Applicable

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SNPs within 2kb

55 from dbSNP Build 142

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UniProt

1 Sequence
Protein Ontology

PR:000004987 neuron-specific vesicular protein calcyon

(term hierarchy)
InterPro Domains

IPR009431 Neuronal vesicle trafficking-associated protein

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All nucleic 16

cDNA 16

Microarray probesets 2

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MGI:1923521

Summaries

All 34

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 9
Earliest

J:65007 Cattanach BM, et al., Two imprinted gene mutations: three phenotypes. Hum Mol Genet. 2000 Sep 22;9(15):2263-73
Latest

J:197462 Dillman AA, et al., mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex. Nat Neurosci. 2013 Apr;16(4):499-506

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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