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Dpm3 Gene Detail
Summary
  • Symbol
    Dpm3
  • Name
    dolichyl-phosphate mannosyltransferase polypeptide 3
  • Synonyms
    1110001H19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915813
    NCBI Gene: 68563
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:89166665-89174386 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 3, 39.03 cM, cytoband F2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    14 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915813
protein coding gene Chr3:89166567-89174386 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027427
protein coding gene Chr3:89466730-89475997 (+)
A/J MGP_AJ_G0027391
protein coding gene Chr3:86504593-86512252 (+)
AKR/J MGP_AKRJ_G0027355
protein coding gene Chr3:88594968-88602606 (+)
BALB/cJ MGP_BALBcJ_G0027400
protein coding gene Chr3:86469032-86477128 (+)
C3H/HeJ MGP_C3HHeJ_G0027142
protein coding gene Chr3:88798249-88806884 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027846
protein coding gene Chr3:92851382-92862451 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025198
protein coding gene Chr3:81984824-81992493 (+)
CAST/EiJ MGP_CASTEiJ_G0026588
protein coding gene Chr3:89147491-89156834 (+)
CBA/J MGP_CBAJ_G0027116
protein coding gene Chr3:96025734-96037220 (+)
DBA/2J MGP_DBA2J_G0027254
protein coding gene Chr3:85883117-85891191 (+)
FVB/NJ MGP_FVBNJ_G0027222
protein coding gene Chr3:84224262-84232366 (+)
LP/J MGP_LPJ_G0027363
protein coding gene Chr3:90542691-90550197 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027242
protein coding gene Chr3:102249727-102257285 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027905
protein coding gene Chr3:88349574-88358057 (+)
PWK/PhJ MGP_PWKPhJ_G0026322
protein coding gene Chr3:85757180-85765511 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026141
protein coding gene Chr3:87517126-87524990 (+)
WSB/EiJ MGP_WSBEiJ_G0026670
protein coding gene Chr3:88741005-88751663 (+)



Homology
more
  • Human Ortholog
    DPM3, dolichyl-phosphate mannosyltransferase subunit 3, regulatory
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DPM3, dolichyl-phosphate mannosyltransferase subunit 3, regulatory
  • Synonyms
    CDG1O, MDDGB15, MDDGC15
  • Links
    NCBI Gene ID: 54344
    neXtProt AC: NX_Q9P2X0
    UniProt: Q9P2X0

  • Chr Location
    1q22; chr1:155139891-155140595 (-)  GRCh38

Human Diseases
more
  • Diseases
    2 with human DPM3 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    22
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Gene trapped
    16
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Dpm3
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042737 Ensembl Gene Model | MGI Sequence Detail 7722 C57BL/6J ±  kb
transcript ENSMUST00000107462 Ensembl | MGI Sequence Detail 827 Not Applicable  
polypeptide ENSMUSP00000103086 Ensembl | MGI Sequence Detail 92 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000006658 dolichol-phosphate mannosyltransferase subunit 3
  • InterPro Domains
    IPR013174 Dolichol-phosphate mannosyltransferase subunit 3
Molecular
Reagents
less
  • All nucleic 39
    cDNA 38
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2139935
References
more
  • Summaries
    All 39
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:62708 Maeda Y, et al., Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3. EMBO J. 2000 Jun 1;19(11):2475-82
  • Latest
    J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory