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Micu2 Gene Detail
Summary
  • Symbol
    Micu2
  • Name
    mitochondrial calcium uptake 2
  • Synonyms
    1110008L20Rik, 4833427E09Rik, Efha1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915764
    NCBI Gene: 68514
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:58153718-58236716 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 30.51 cM, cytoband C2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    266 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915764
 protein coding gene Chr14:58153718-58236719 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021415
 protein coding gene Chr14:52143856-52238253 (-)
A/J MGP_AJ_G0021376
 protein coding gene Chr14:51090237-51175035 (-)
AKR/J MGP_AKRJ_G0021351
 protein coding gene Chr14:52885378-52967149 (-)
BALB/cJ MGP_BALBcJ_G0021379
 protein coding gene Chr14:51036825-51120273 (-)
C3H/HeJ MGP_C3HHeJ_G0021158
 protein coding gene Chr14:52544013-52636406 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021818
 protein coding gene Chr14:54698823-54797274 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019357
 protein coding gene Chr14:49173654-49252860 (-)
CAST/EiJ MGP_CASTEiJ_G0020676
 protein coding gene Chr14:48894730-48981950 (-)
CBA/J MGP_CBAJ_G0021125
 protein coding gene Chr14:56329607-56421140 (-)
DBA/2J MGP_DBA2J_G0021246
 protein coding gene Chr14:50761318-50844081 (-)
FVB/NJ MGP_FVBNJ_G0021227
 protein coding gene Chr14:50153949-50238304 (-)
LP/J MGP_LPJ_G0021321
 protein coding gene Chr14:53176696-53265468 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021255
 protein coding gene Chr14:55678566-55775543 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021842
 protein coding gene Chr14:52032690-52119015 (-)
PWK/PhJ MGP_PWKPhJ_G0020419
 protein coding gene Chr14:47309788-47393612 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020252
 protein coding gene Chr14:48116138-48200143 (-)
WSB/EiJ MGP_WSBEiJ_G0020728
 protein coding gene Chr14:52348226-52437412 (-)



Homology
more
  • Human Ortholog
    MICU2, mitochondrial calcium uptake 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MICU2, mitochondrial calcium uptake 2
  • Synonyms
    1110008L20Rik, EFHA1
  • Links
    NCBI Gene ID: 221154
    neXtProt AC: NX_Q8IYU8
    UniProt: Q8IYU8

  • Chr Location
    13q12.11; chr13:21492691-21604181 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit an enlarged heart left atrium along with delayed calcium reuptake and decreased relaxation rates by cardiomyocytes, and develop abdominal aortic aneurysms with spontaneous rupture following angiotensin II treatment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    11
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68514 NCBI Gene Model | MGI Sequence Detail 82999 C57BL/6J ±  kb
    transcript NR_184778 RefSeq | MGI Sequence Detail 2349 C57BL/6  
    polypeptide Q8CD10 UniProt | EBI | MGI Sequence Detail 432 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1921008, MGI:2145758
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:322729 Singh R, et al., Uncontrolled mitochondrial calcium uptake underlies the pathogenesis of neurodegeneration in MICU1-deficient mice and patients. Sci Adv. 2022 Mar 18;8(11):eabj4716
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory