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Tomm5 Gene Detail
Summary
  • Symbol
    Tomm5
  • Name
    translocase of outer mitochondrial membrane 5
  • Synonyms
    1110019J04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915762
    NCBI Gene: 68512
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr4:45105209-45108113 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 23.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    33 from dbSNP Build 142
  • Strain Annotations
    9
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915762
protein coding gene Chr4:45105208-45108114 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0028198
protein coding gene Chr4:41772589-41775507 (-)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0028218
protein coding gene Chr4:41855091-41857997 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0028659
protein coding gene Chr4:44956838-44959748 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0027379
protein coding gene Chr4:42918651-42922278 (-)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0028055
protein coding gene Chr4:41670724-41673528 (-)
FVB/NJ MGP_FVBNJ_G0028022
protein coding gene Chr4:40897548-40900754 (-)
LP/J MGP_LPJ_G0028154
protein coding gene Chr4:43373507-43376412 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028046
protein coding gene Chr4:49491211-49494591 (-)
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    TOMM5, translocase of outer mitochondrial membrane 5
  • Vertebrate Orthologs
    4
  • Human Ortholog
    TOMM5, translocase of outer mitochondrial membrane 5
    Orthology source: HGNC
  • Synonyms
    bA613M10.3, C9orf105, Tom5
  • Links
    NCBI Gene ID: 401505
    neXtProt AC: NX_Q8N4H5
    UniProt: Q8N4H5

  • Chr Location
    9p13.2; chr9:37588413-37592639 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit partial neonatal lethality, cryptogenic organizing pneumonia, intra-alveolar fibrosis, diffuse moderate eosinophilic granulocytosis in the bone marrow, and thymus atrophy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 68512 NCBI Gene Model | MGI Sequence Detail 2905 C57BL/6J ±  kb
transcript NM_001134646 RefSeq | MGI Sequence Detail 701 C57BL/6  
polypeptide B1AXP6 UniProt | EBI | MGI Sequence Detail 51 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000033021 mitochondrial import receptor subunit TOM5 homolog
  • InterPro Domains
    IPR029179 Mitochondrial import receptor subunit TOM5, metazoa
    IPR019603 Mitochondrial outer membrane translocase complex, subunit Tom5
Molecular
Reagents
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  • All nucleic 82
    cDNA 82

    Microarray probesets 3
References
more
  • Summaries
    All 25
    Gene Ontology 4
    Phenotypes 3
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:186382 Vogel P, et al., Cryptogenic organizing pneumonia in Tomm5(-/-) mice. Vet Pathol. 2013 Jan;50(1):65-75

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/09/2019
MGI 6.13
The Jackson Laboratory