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Ctnnbip1 Gene Detail
Summary
  • Symbol
    Ctnnbip1
  • Name
    catenin beta interacting protein 1
  • Synonyms
    1110008O09Rik, 2310001I19Rik, Catnbip1, ICAT
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915756
    NCBI Gene: 67087
  • Gene Overview
    MyGene.info: CTNNBIP1
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:149518241-149566437 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 79.66 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    390 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915756
protein coding gene Chr4:149518236-149566437 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029142
protein coding gene Chr4:153371863-153422479 (+)
A/J MGP_AJ_G0029107
protein coding gene Chr4:146973715-147023289 (+)
AKR/J MGP_AKRJ_G0029055
protein coding gene Chr4:150996193-151045444 (+)
BALB/cJ MGP_BALBcJ_G0029123
protein coding gene Chr4:147473730-147522741 (+)
C3H/HeJ MGP_C3HHeJ_G0028844
protein coding gene Chr4:151556378-151604974 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029572
protein coding gene Chr4:158902560-158964947 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026818
protein coding gene Chr4:139385805-139434187 (+)
CAST/EiJ MGP_CASTEiJ_G0028257
protein coding gene Chr4:148782894-148837931 (+)
CBA/J MGP_CBAJ_G0028806
protein coding gene Chr4:163576299-163626348 (+)
DBA/2J MGP_DBA2J_G0028955
protein coding gene Chr4:147074250-147122648 (+)
FVB/NJ MGP_FVBNJ_G0028919
protein coding gene Chr4:146187695-146237610 (+)
LP/J MGP_LPJ_G0029045
protein coding gene Chr4:153288373-153342318 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028946
protein coding gene Chr4:166805818-166858995 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029604
protein coding gene Chr4:151494458-151544609 (+)
PWK/PhJ MGP_PWKPhJ_G0027977
protein coding gene Chr4:143080363-143129337 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027811
protein coding gene Chr4:145738810-145786570 (+)
WSB/EiJ MGP_WSBEiJ_G0028337
protein coding gene Chr4:151645147-151696837 (+)



Homology
more
  • Human Ortholog
    CTNNBIP1, catenin beta interacting protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CTNNBIP1, catenin beta interacting protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ICAT
  • Links
    NCBI Gene ID: 56998
    neXtProt AC: NX_Q9NSA3
    UniProt: Q9NSA3

  • Chr Location
    1p36.22; chr1:9848276-9910322 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display neonatal lethality associated with rupture of the gut, posteriorized neural cell fate within the neural plate, abnormal craniofacial morphology, and renal agenesis due to arrest of ureteric bud branching.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67087 NCBI Gene Model | MGI Sequence Detail 48197 C57BL/6J ±  kb
    transcript NM_023465 RefSeq | MGI Sequence Detail 2686 C57BL/6  
    polypeptide Q9JJN6 UniProt | EBI | MGI Sequence Detail 81 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1914337, MGI:2140573
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 9
      Gene Ontology 11
      Phenotypes 13
    • Earliest
      J:74520 Tago K, et al., Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein. Genes Dev. 2000 Jul 15;14(14):1741-9
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory