Ctnnbip1 MGI Mouse Gene Detail - MGI:1915756 - catenin beta interacting protein 1

Symbol

Ctnnbip1
Name

catenin beta interacting protein 1
Synonyms

1110008O09Rik, 2310001I19Rik, Catnbip1, ICAT

Feature Type

protein coding gene
IDs

MGI:1915756
NCBI Gene: 67087
Alliance

genome feature page
Transcription Start Sites

8 TSS

Sequence Map

Chr4:149602698-149650894 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 79.66 cM
Mapping Data

2 experiments

SNPs within 2kb

398 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915756	protein coding gene	Chr4:149602693-149650894 (+)
129S1/SvImJ	ENSMUSG00200041896	protein coding gene	Chr4:140643283-140692196 (+)
A/J	ENSMUSG00195015643	protein coding gene	Chr4:142299912-142348180 (+)
AKR/J	ENSMUSG00220045612	protein coding gene	Chr4:141887240-141935473 (+)
BALB/cJ	ENSMUSG00180044515	protein coding gene	Chr4:139982513-140030786 (+)
C3H/HeJ	ENSMUSG00175016104	protein coding gene	Chr4:143267675-143315900 (+)
C57BL/6NJ	ENSMUSG00215021147	protein coding gene	Chr4:142106786-142154986 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026818	protein coding gene	Chr4:139385805-139434187 (+)
CAST/EiJ	ENSTCUG00005030782	protein coding gene	Chr4:145941651-145989841 (+)
CBA/J	ENSMUSG00210004226	protein coding gene	Chr4:141919307-141967536 (+)
DBA/2J	ENSMUSG00185013761	protein coding gene	Chr4:145480798-145529025 (+)
FVB/NJ	ENSMUSG00205034562	protein coding gene	Chr4:140371960-140420126 (+)
JF1/MsJ	ENSUMUG00000007114	protein coding gene	Chr4:148494240-148542404 (+)
LP/J	ENSMUSG00230014335	protein coding gene	Chr4:152215104-152263912 (+)
NOD/ShiLtJ	ENSMUSG00190003236	protein coding gene	Chr4:141586695-141635623 (+)
NZO/HlLtJ	ENSMUSG00225023145	protein coding gene	Chr4:156214455-156262705 (+)
PWK/PhJ	ENSLUMG00010044899	protein coding gene	Chr4:140770322-140818552 (+)
SPRET/EiJ	ENSMSPG00010021642	protein coding gene	Chr4:142719698-142738669 (+)
WSB/EiJ	ENSIUOG00005041102	protein coding gene	Chr4:139753252-139801273 (+)

Human Ortholog

CTNNBIP1, catenin beta interacting protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CTNNBIP1, catenin beta interacting protein 1
Synonyms

ICAT
Links

HGNC:16913

NCBI Gene ID: 56998

UniProt: Q9NSA3
Chr Location

1p36.22; chr1:9848269-9910368 (-) GRCh38

MGI Vertebrate Homology

Ctnnbip1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CTNNBIP1
Gene Tree

Ctnnbip1

less

Phenotype Summary

23 phenotypes from 2 alleles in 2 genetic backgrounds
2 images
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

2
Gene trapped

9
Targeted

5
Genomic Mutations

1 involving Ctnnbip1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display neonatal lethality associated with rupture of the gut, posteriorized neural cell fate within the neural plate, abnormal craniofacial morphology, and renal agenesis due to arrest of ureteric bud branching.

less

All GO Annotations

66
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

720
Tissues

95
cDNA Data

11
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ctnnbip1

ZFIN ctnnbip1

less

All Sequences

45
RefSeq

4
UniProt

1
CCDS

CCDS38975.1

Ensembl

ENSMUSG00000028988 (Evidence)
NCBI Gene

67087

			Length	Strain/Species	Flank
genomic	67087	NCBI Gene Model \| MGI Sequence Detail	48197	C57BL/6J	± kb
transcript	NM_023465	RefSeq \| MGI Sequence Detail	2686	C57BL/6
polypeptide	Q9JJN6	UniProt \| EBI \| MGI Sequence Detail	81	Not Applicable

less

UniProt

1 Sequence
Protein Ontology

PR:000006010 beta-catenin-interacting protein 1

(term hierarchy)
InterPro Domains

IPR009428 Beta-catenin-interacting ICAT domain

IPR036911 Beta-catenin-interacting ICAT superfamily

less

All nucleic 12

cDNA 11

Primer pair 1

Antibodies 1

Microarray probesets 5

less

MGI:1914337, MGI:2140573

Summaries

All 61

Developmental Gene Expression 9

Gene Ontology 14

Phenotypes 15
Earliest

J:74520 Tago K, et al., Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein. Genes Dev. 2000 Jul 15;14(14):1741-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ctnnbip1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr40334	Chr4:149602584-149602614 (+)	-99 bp
Tssr40335	Chr4:149602652-149602666 (+)	-39 bp
Tssr40336	Chr4:149602673-149602734 (+)	6 bp
Tssr40337	Chr4:149602745-149602765 (+)	57 bp
Tssr40338	Chr4:149624099-149624116 (+)	21,410 bp
Tssr40339	Chr4:149624321-149624335 (+)	21,630 bp
Tssr40340	Chr4:149629559-149629593 (+)	26,878 bp
Tssr40341	Chr4:149637646-149637650 (+)	34,950 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29