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Arel1 Gene Detail
Summary
  • Symbol
    Arel1
  • Name
    apoptosis resistant E3 ubiquitin protein ligase 1
  • Synonyms
    1110018G07Rik, mKIAA0317
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915747
    NCBI Gene: 68497
Location & Maps
more
  • Sequence Map
    Chr12:84918148-84970900 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      52753 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 39.46 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    AREL1, apoptosis resistant E3 ubiquitin protein ligase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AREL1, apoptosis resistant E3 ubiquitin protein ligase 1
    Orthology source: HomoloGene
  • Synonyms
    FIEL1, KIAA0317
  • Links
    NCBI Gene ID: 9870
    neXtProt AC: NX_O15033

  • Chr Location
    14q24.3; chr14:74661252-74713115 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8885
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: AREL1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Targeted
    3
  • Genomic Mutations
    1 involving Arel1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035485 VEGA Gene Model | MGI Sequence Detail 52753 C57BL/6J ±  kb
transcript OTTMUST00000090852 VEGA | MGI Sequence Detail 5446 Not Applicable  
polypeptide OTTMUSP00000049942 VEGA | MGI Sequence Detail 823 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    288 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 5
Other
Accession IDs
less
MGI:2144874, MGI:2145051
References
more
  • Summaries
    All 26
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:198601 Kim JB, et al., Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2, and ARTS. J Biol Chem. 2013 Apr 26;288(17):12014-21

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory