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Mpzl1 Gene Detail
Summary
  • Symbol
    Mpzl1
  • Name
    myelin protein zero-like 1
  • Synonyms
    1110007A10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915731
    NCBI Gene: 68481
  • Gene Overview
    MyGene.info: MPZL1
Location & Maps
more
  • Sequence Map
    Chr1:165592240-165634538 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      42299 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 72.94 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    MPZL1, myelin protein zero like 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MPZL1, myelin protein zero like 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MPZL1b, PZR, PZR1b, PZRa, PZRb
  • Links
    NCBI Gene ID: 9019
    neXtProt AC: NX_O95297

  • Chr Location
    1q24.2; chr1:167721950-167791919 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2939
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: MPZL1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    27
  • Chemically induced (other)
    2
  • Gene trapped
    21
  • Targeted
    4
  • Genomic Mutations
    2 involving Mpzl1
  • Incidental Mutations
    APF
Phenotypic analysis of mice homozygous for a gene trap allele indicates this mutation has no notable phenotype in any parameter tested.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049918 VEGA Gene Model | MGI Sequence Detail 42299 C57BL/6J ±  kb
transcript OTTMUST00000127075 VEGA | MGI Sequence Detail 2285 Not Applicable  
polypeptide OTTMUSP00000068658 VEGA | MGI Sequence Detail 270 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    424 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 155
    cDNA 153
    Primer pair 2

    Microarray probesets 4
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory