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Tada3 Gene Detail
Summary
  • Symbol
    Tada3
  • Name
    transcriptional adaptor 3
  • Synonyms
    1110004B19Rik, ADA3, Tada3l
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915724
    NCBI Gene: 101206
  • Gene Overview
    MyGene.info: TADA3
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:113366640-113377940 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 52.75 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    137 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915724
protein coding gene Chr6:113366025-113377940 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031119
protein coding gene Chr6:115882981-115894093 (-)
A/J MGP_AJ_G0031088
protein coding gene Chr6:111443714-111454825 (-)
AKR/J MGP_AKRJ_G0031019
protein coding gene Chr6:114435177-114446255 (-)
BALB/cJ MGP_BALBcJ_G0031099
protein coding gene Chr6:111389575-111400682 (-)
C3H/HeJ MGP_C3HHeJ_G0030609
protein coding gene Chr6:69849705-69861831 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031558
protein coding gene Chr6:118888381-118899483 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028722
protein coding gene Chr6:108444084-108455448 (-)
CAST/EiJ MGP_CASTEiJ_G0030206
protein coding gene Chr6:114873434-114884845 (-)
CBA/J MGP_CBAJ_G0030785
protein coding gene Chr6:123580237-123591312 (-)
DBA/2J MGP_DBA2J_G0030938
protein coding gene Chr6:110522943-110534011 (-)
FVB/NJ MGP_FVBNJ_G0030892
protein coding gene Chr6:109522200-109533331 (-)
LP/J MGP_LPJ_G0031018
protein coding gene Chr6:115920740-115931844 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030926
protein coding gene Chr6:127846829-127857943 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031585
protein coding gene Chr6:114446887-114458059 (-)
PWK/PhJ MGP_PWKPhJ_G0029922
protein coding gene Chr6:109475333-109487598 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029750
protein coding gene Chr6:113265967-113277027 (-)
WSB/EiJ MGP_WSBEiJ_G0030290
protein coding gene Chr6:114825782-114837107 (-)



Homology
more
  • Human Ortholog
    TADA3, transcriptional adaptor 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TADA3, transcriptional adaptor 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADA3, hADA3, NGG1, STAF54, TADA3L
  • Links
    NCBI Gene ID: 10474
    neXtProt AC: NX_O75528
    UniProt: O75528

  • Chr Location
    3p25.3; chr3:9779964-9793011 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4633
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TADA3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality between E3.5 and E8.5 associated with impaired proliferation of trophoblast cells and absence of inner cell mass.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 101206 NCBI Gene Model | MGI Sequence Detail 11301 C57BL/6J ±  kb
    transcript NM_133932 RefSeq | MGI Sequence Detail 1855 C57BL/6  
    polypeptide Q8R0L9 UniProt | EBI | MGI Sequence Detail 432 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 81
      cDNA 81

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2141524
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:190249 Mohibi S, et al., Mammalian alteration/deficiency in activation 3 (Ada3) is essential for embryonic development and cell cycle progression. J Biol Chem. 2012 Aug 24;287(35):29442-56

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory