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Mob1b Gene Detail
Summary
  • Symbol
    Mob1b
  • Name
    MOB kinase activator 1B
  • Synonyms
    1110003E08Rik, Mobkl1a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915723
    NCBI Gene: 68473
  • Gene Overview
    MyGene.info: MOB1B
Location & Maps
more
  • Sequence Map
    Chr5:88720855-88764220 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      43366 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 43.92 cM, cytoband E2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MOB1B, MOB kinase activator 1B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MOB1B, MOB kinase activator 1B
    Orthology source: HomoloGene
  • Synonyms
    MATS2, MOB4A, MOBKL1A
  • Links
    NCBI Gene ID: 92597
    neXtProt AC: NX_Q7L9L4

  • Chr Location
    4q13.3; chr4:70901974-70988174 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 61676
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: MOB1B
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    35 phenotypes from multigenic genotypes
    6 images
    13 phenotype references
  • All Mutations and Alleles
    15
  • Chemically induced (other)
    2
  • Gene trapped
    9
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    2
  • Genomic Mutations
    4 involving Mob1b
  • Incidental Mutations
Mice homozygous for a gene trap allele exhibit no abnormal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025213 VEGA Gene Model | MGI Sequence Detail 43366 C57BL/6J ±  kb
transcript OTTMUST00000062063 VEGA | MGI Sequence Detail 8967 Not Applicable  
polypeptide OTTMUSP00000030548 VEGA | MGI Sequence Detail 221 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    177 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000010504 MOB kinase activator 1B
  • InterPro Domains
    IPR005301 MOB kinase activator family
Molecular
Reagents
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  • All nucleic 18
    cDNA 18

    Microarray probesets 6
Other
Accession IDs
less
MGI:2141027
References
more
  • Summaries
    All 32
    Gene Ontology 2
    Phenotypes 13
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:193981 Nishio M, et al., Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice. J Clin Invest. 2012 Dec 3;122(12):4505-18

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory