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Impad1
Gene Detail
Symbol

Name
ID
Impad1
inositol monophosphatase domain containing 1
MGI:1915720
Synonyms
1110001C20Rik, gPAPP, Jaws
Feature Type
protein coding gene
Genetic Map
Chromosome 4
2.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:4762484-4793355 bp, - strand
From VEGA annotation of GRCm38

  30872 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9852  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: IMPAD1
Protein SuperFamily: metal-dependent/Li(+)-inhibited phosphomonoesterase
Gene Tree: Impad1

Human
homologs
IMPAD1, inositol monophosphatase domain containing 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 54928
neXtProt AC: NX_Q9NX62

Human Synonyms: GPAPP, IMP 3, IMP-3, IMPA3

Human Chr (Location): 8q12.1; chr8:56957929-56993871 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human IMPAD1

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Targeted(2)
Incidental mutations (data from APF )
 
Homozygous null mutants are neonatal lethal with growth retardation. Mutant embryo shows craniofacial abnormalities and shortened limbs.
 
Phenotype Images(2)
Interactions
Impad1 interacts with 421 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (28)    Tissues (14)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
In situ reporter (knock in) 28
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase impad1    NEW 
Molecular
reagents
All nucleic(12) cDNA(12)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000004196 (Evidence)
Ensembl Gene Model ENSMUSG00000066324 (Evidence)
Entrez Gene 242291 (Evidence)
DFCI TC1658103, TC1627939
DoTS DT.94388374
NIA Mouse Gene Index U372725, U024816
EC 3.1.3.25, 3.1.3.7
Consensus CDS Project CCDS17947.1
International Mouse Phenotyping Consortium Status Impad1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004196 VEGA Gene Model | MGI Sequence Detail 30872 C57BL/6J ±  kb
transcript OTTMUST00000009508 VEGA | MGI Sequence Detail 6543 Not Applicable 
polypeptide OTTMUSP00000004620 VEGA | MGI Sequence Detail 356 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(122 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000760 Inositol monophosphatase
InterPro IPR020550 Inositol monophosphatase, conserved site
Protein Ontology PR:000009020 inositol monophosphatase 3
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:194247 Hudson BH, et al., Role for cytoplasmic nucleotide hydrolysis in hepatic function and protein synthesis. Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5040-5
All references(36)
Other
accession IDs
MGI:2135554, MGI:2140139, MGI:2140409

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory