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Impad1
Gene Detail
Symbol

Name
ID
Impad1
inositol monophosphatase domain containing 1
MGI:1915720
Synonyms
1110001C20Rik, gPAPP, Jaws
Feature Type
protein coding gene
Genetic Map
Chromosome 4
2.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:4762484-4793355 bp, - strand
From VEGA annotation of GRCm38

  30872 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9852  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: metal-dependent/Li(+)-inhibited phosphomonoesterase
Gene Tree: Impad1

Human
homologs
Human Homolog IMPAD1, inositol monophosphatase domain containing 1
NCBI Gene ID 54928
neXtProt AC  NX_Q9NX62
Human Synonyms  GPAPP, IMP 3, IMP-3, IMPA3
Human Chr (Location)  8q12.1; chr8:56957929-56993871 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human IMPAD1
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Targeted(2)
Incidental mutations (data from APF )
 
Homozygous null mutants are neonatal lethal with growth retardation. Mutant embryo shows craniofacial abnormalities and shortened limbs.
 
Phenotype Images(2)
Interactions
Impad1 interacts with 422 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (28)    Tissues (14)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
In situ reporter (knock in) 28
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(12)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000004196 (Evidence)
Ensembl Gene ModelENSMUSG00000066324 (Evidence)
Entrez Gene242291 (Evidence)
DFCITC1627939, TC1658103
DoTSDT.94388374
NIA Mouse Gene IndexU024816, U372725
EC3.1.3.25, 3.1.3.7
Consensus CDS ProjectCCDS17947.1
International Mouse Knockout Project StatusImpad1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004196 VEGA Gene Model | MGI Sequence Detail 30872 C57BL/6J ±  kb
transcript OTTMUST00000009508 VEGA | MGI Sequence Detail 6543 Not Applicable 
polypeptide OTTMUSP00000004620 VEGA | MGI Sequence Detail 356 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(122 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000760 Inositol monophosphatase
InterPro IPR020550 Inositol monophosphatase, conserved site
Protein Ontology PR:000009020 inositol monophosphatase 3
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:194247 Hudson BH, et al., Role for cytoplasmic nucleotide hydrolysis in hepatic function and protein synthesis. Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5040-5
All references(36)
Other
accession IDs
MGI:2135554, MGI:2140139, MGI:2140409

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory