Dhrs7c Gene Detail

Summary

• Symbol
  Dhrs7c
• Name
  dehydrogenase/reductase (SDR family) member 7C
• Synonyms
  1110001P11Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1915710
  NCBI Gene: 68460
• Alliance
  gene page
• Transcription Start Sites
  3 TSS

Location &
Maps

• Sequence Map
  Chr11:67798271-67816002 bp, + strand
• From NCBI annotation of GRCm38
  

  View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 11, 41.13 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  232 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915710	protein coding gene	Chr11:67798187-67816002 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018495	protein coding gene	Chr11:68117416-68135238 (+)
A/J	MGP_AJ_G0018464	protein coding gene	Chr11:65571424-65589228 (+)
AKR/J	MGP_AKRJ_G0018433	protein coding gene	Chr11:67530458-67548280 (+)
BALB/cJ	MGP_BALBcJ_G0018435	protein coding gene	Chr11:65850641-65868498 (+)
C3H/HeJ	MGP_C3HHeJ_G0018248	protein coding gene	Chr11:67542629-67560449 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018887	protein coding gene	Chr11:70195149-70212963 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016531	protein coding gene	Chr11:62523023-62540800 (+)
CAST/EiJ	MGP_CASTEiJ_G0017804	protein coding gene	Chr11:67766759-67784677 (+)
CBA/J	MGP_CBAJ_G0018222	protein coding gene	Chr11:73296255-73315290 (+)
DBA/2J	MGP_DBA2J_G0018331	protein coding gene	Chr11:65172512-65190335 (+)
FVB/NJ	MGP_FVBNJ_G0018321	protein coding gene	Chr11:64781068-64799486 (+)
LP/J	MGP_LPJ_G0018402	protein coding gene	Chr11:68690907-68710113 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018344	protein coding gene	Chr11:74049063-74067150 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018928	protein coding gene	Chr11:67778309-67796162 (+)
PWK/PhJ	MGP_PWKPhJ_G0017579	protein coding gene	Chr11:65787968-65806328 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017367	protein coding gene	Chr11:67608020-67626649 (+)
WSB/EiJ	MGP_WSBEiJ_G0017857	protein coding gene	Chr11:67384771-67402718 (+)

Homology

• Human Ortholog
  DHRS7C, dehydrogenase/reductase 7C

• Vertebrate Orthologs
  10

• Human Ortholog
  DHRS7C, dehydrogenase/reductase 7C
  Orthology source: HomoloGene, HGNC
• Synonyms
  SDR32C2
• Links
  HGNC:32423

  NCBI Gene ID: 201140

  neXtProt AC: NX_A6NNS2

  UniProt: A6NNS2

  
  
• Chr Location
  17p13.1; chr17:9771434-9791297 (-)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 19108
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: DHRS7C
• Gene Tree
  Dhrs7c
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  5 phenotype references
  

• All Mutations and Alleles
  3
• Chemically induced (other)
  1
• Endonuclease-mediated
  1
• Transgenic
  1
• Genomic Mutations
  1 involving Dhrs7c
• Incidental Mutations
  CvDC
• Find Mice (IMSR)
  0 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  11
• GO References
  4

• External Resources
  FuncBase

Expression

• cDNA Data
  15

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase dhrs7c
  ZFIN dhrs7ca

Interactions

• Dhrs7c interacts with 13 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

Sequences &
Gene Models

• All Sequences
  39
• RefSeq
  2
• UniProt
  1
• CCDS
  CCDS48822.1
• UniGene
  22167

• Ensembl
  ENSMUSG00000033044 (Evidence)
• NCBI Gene
  68460

Representative Sequences			Length	Strain/Species
genomic	68460	NCBI Gene Model | MGI Sequence Detail	17732	C57BL/6J
transcript	NM_001013013	RefSeq | MGI Sequence Detail	1129	C57BL/6
polypeptide	Q8CHS7	UniProt | EBI | MGI Sequence Detail	311	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• Protein Ontology
  PR:000006469 dehydrogenase/reductase SDR family member 7C
  (term hierarchy)
• EC
  1.1.-.-
• InterPro Domains
  IPR036291 NAD(P)-binding domain superfamily
  IPR020904 Short-chain dehydrogenase/reductase, conserved site
  IPR002347 Short-chain dehydrogenase/reductase SDR

Molecular
Reagents

• All nucleic 15

  cDNA 15

  
  

  Microarray probesets 4

Other
Accession IDs

MGI:2144071

References

• Summaries
  All 29

  Gene Ontology 4

  Phenotypes 5
• Earliest
  J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
• Latest
  J:260197 Ruiz A, et al., Over-expression of a retinol dehydrogenase (SRP35/DHRS7C) in skeletal muscle activates mTORC2, enhances glucose metabolism and muscle performance. Sci Rep. 2018 Jan 12;8(1):636

TSS for Dhrs7c:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102284	Chr11:67798250-67798259 (+)	-16 bp
Tssr102285	Chr11:67798269-67798286 (+)	7 bp
Tssr102286	Chr11:67798290-67798298 (+)	23 bp