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Steap3 Gene Detail
Summary
  • Symbol
    Steap3
  • Name
    STEAP family member 3
  • Synonyms
    1010001D01Rik, pHyde
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915678
    NCBI Gene: 68428
  • Gene Overview
    MyGene.info: STEAP3
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:120226414-120271082 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 52.66 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    320 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915678
protein coding gene Chr1:120190757-120272705 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016405
protein coding gene Chr1:122979382-123060997 (-)
A/J MGP_AJ_G0016388
protein coding gene Chr1:118569031-118650385 (-)
AKR/J MGP_AKRJ_G0016353
protein coding gene Chr1:122069717-122150001 (-)
BALB/cJ MGP_BALBcJ_G0016348
protein coding gene Chr1:118831175-118912274 (-)
C3H/HeJ MGP_C3HHeJ_G0016174
protein coding gene Chr1:122225259-122308666 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016809
protein coding gene Chr1:127659928-127742057 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014522
protein coding gene Chr1:112213776-112290970 (-)
CAST/EiJ MGP_CASTEiJ_G0015755
protein coding gene Chr1:121026724-121120098 (-)
CBA/J MGP_CBAJ_G0016147
protein coding gene Chr1:132088113-132173077 (-)
DBA/2J MGP_DBA2J_G0016253
protein coding gene Chr1:117592967-117673076 (-)
FVB/NJ MGP_FVBNJ_G0016252
protein coding gene Chr1:116347765-116428916 (-)
LP/J MGP_LPJ_G0016324
protein coding gene Chr1:124330450-124414807 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016277
protein coding gene Chr1:137832564-137916297 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016845
protein coding gene Chr1:121780344-121861935 (-)
PWK/PhJ MGP_PWKPhJ_G0015541
protein coding gene Chr1:116573172-116662002 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015329
protein coding gene Chr1:120677489-120759582 (-)
WSB/EiJ MGP_WSBEiJ_G0015817
protein coding gene Chr1:121662080-121743923 (-)



Homology
more
  • Human Ortholog
    STEAP3, STEAP3 metalloreductase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    STEAP3, STEAP3 metalloreductase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AHMIO2, dudlin-2, dudulin-2, pHyde, STMP3, TSAP6
  • Links
    NCBI Gene ID: 55240
    neXtProt AC: NX_Q658P3
    UniProt: Q658P3

  • Chr Location
    2q14.2; chr2:119222476-119265652 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human STEAP3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene results in microcytic anemia, increased erythrocyte cell number, abnormal reticulocyte morphology, anisopoikilocytosis, decreased mean corpuscular hemoglobin, decreased mean corpuscular volume, and thrombocytosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68428 NCBI Gene Model | MGI Sequence Detail 44669 C57BL/6J ±  kb
    transcript NM_001085409 RefSeq | MGI Sequence Detail 3142 C57BL/6  
    polypeptide Q8CI59 UniProt | EBI | MGI Sequence Detail 488 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • EC
    • InterPro Domains
      IPR013130 Ferric reductase transmembrane component-like domain
      IPR036291 NAD(P)-binding domain superfamily
      IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 29

      Microarray probesets 4
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 12
      Phenotypes 21
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:239497 Sikkeland J, et al., STAMPing at the crossroads of normal physiology and disease states. Mol Cell Endocrinol. 2016 Apr 15;425:26-36

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory