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Steap3
Gene Detail
Symbol

Name
ID
Steap3
STEAP family member 3
MGI:1915678
Synonyms
1010001D01Rik, pHyde
Feature Type
protein coding gene
Genetic Map
Chromosome 1
52.66 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:120190757-120272705 bp, - strand
From VEGA annotation of GRCm38

  81949 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10084  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Steap3

Human
homologs
Human Homolog STEAP3, STEAP family member 3, metalloreductase
NCBI Gene ID 55240
neXtProt AC  NX_Q658P3
Human Synonyms  AHMIO2, dudlin-2, STMP3, TSAP6
Human Chr (Location)  2q14.2; chr2:119222730-119265652 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human STEAP3
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Chemically induced (ENU)(1) Gene trapped(13) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation of this gene are anemic, have a deficiency in transferrin-mediated iron uptake by reticulocytes, and reduced exosomal protein secretion in mouse embryo fibroblasts (MEFs) and bone marrow-derived dendritic cells (BMDCs).
 
Interactions
Steap3 interacts with 287 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process apoptotic process, cell cycle, ...
Component cell, endosome, ...
Function cupric reductase activity, ferric-chelate reductase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (98)    Tissues (16)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 98
cDNA source data(27)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(28) cDNA(28)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000021495 (Evidence)
Ensembl Gene ModelENSMUSG00000026389 (Evidence)
Entrez Gene68428 (Evidence)
UniGene181033
DFCITC1581728, TC1651780, TC1705944
DoTSDT.101331492, DT.101367554, DT.101716632, DT.40138860, DT.485896, DT.97334746
EC1.16.1.-
Consensus CDS ProjectCCDS48343.1
International Mouse Knockout Project StatusSteap3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021495 VEGA Gene Model | MGI Sequence Detail 81949 C57BL/6J ±  kb
transcript OTTMUST00000050946 VEGA | MGI Sequence Detail 2873 Not Applicable 
polypeptide OTTMUSP00000023907 VEGA | MGI Sequence Detail 526 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(617 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013130 Ferric reductase transmembrane component-like domain
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000015732 metalloreductase STEAP3
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:186171 Wan C, et al., Exosome-related multi-pass transmembrane protein TSAP6 is a target of rhomboid protease RHBDD1-induced proteolysis. PLoS One. 2012;7(5):e37452
All references(40)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory