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Steap3
Gene Detail
Symbol

Name
ID
Steap3
STEAP family member 3
MGI:1915678
Synonyms
1010001D01Rik, pHyde
Feature Type
protein coding gene
Genetic Map
Chromosome 1
52.66 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:120190757-120272705 bp, - strand
From VEGA annotation of GRCm38

  81949 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10084  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: STEAP3
Gene Tree: Steap3

Human
homologs
STEAP3, STEAP family member 3, metalloreductase
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 55240
neXtProt AC: NX_Q658P3

Human Synonyms: AHMIO2, dudlin-2, STMP3, TSAP6

Human Chr (Location): 2q14.2; chr2:119222731-119265652 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human STEAP3

Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Chemically induced (ENU)(1) Gene trapped(13) Spontaneous(1) Targeted(4)
Genomic Mutations involving Steap3 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a targeted mutation of this gene are anemic, have a deficiency in transferrin-mediated iron uptake by reticulocytes, and reduced exosomal protein secretion in mouse embryo fibroblasts (MEFs) and bone marrow-derived dendritic cells (BMDCs).
 
Interactions
Steap3 interacts with 286 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process apoptotic process, cell cycle, ...
Component cell, endosome, ...
Function cupric reductase activity, ferric-chelate reductase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (98)    Tissues (16)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 98
cDNA source data(27)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100496101    NEW 
Molecular
reagents
All nucleic(28) cDNA(28)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000021495 (Evidence)
Ensembl Gene Model ENSMUSG00000026389 (Evidence)
Entrez Gene 68428 (Evidence)
UniGene 181033
DFCI TC1705944, TC1651780, TC1581728
DoTS DT.101367554, DT.101331492, DT.40138860, DT.101716632, DT.97334746, DT.485896
EC 1.16.1.-
Consensus CDS Project CCDS48343.1
International Mouse Phenotyping Consortium Status Steap3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021495 VEGA Gene Model | MGI Sequence Detail 81949 C57BL/6J ±  kb
transcript OTTMUST00000050946 VEGA | MGI Sequence Detail 2873 Not Applicable 
polypeptide OTTMUSP00000023907 VEGA | MGI Sequence Detail 526 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(617 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013130 Ferric reductase transmembrane component-like domain
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000015732 metalloreductase STEAP3
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:186171 Wan C, et al., Exosome-related multi-pass transmembrane protein TSAP6 is a target of rhomboid protease RHBDD1-induced proteolysis. PLoS One. 2012;7(5):e37452
All references(39)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory