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Sycn Gene Detail
Summary
  • Symbol
    Sycn
  • Name
    syncollin
  • Synonyms
    0910001K16Rik, 1810038B08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915666
    NCBI Gene: 68416
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:28540885-28542209 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 16.83 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    27 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915666
protein coding gene Chr7:28540885-28542210 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031951
protein coding gene Chr7:27345925-27347250 (+)
A/J MGP_AJ_G0031929
protein coding gene Chr7:26677201-26678526 (+)
AKR/J MGP_AKRJ_G0031861
protein coding gene Chr7:27354213-27355538 (+)
BALB/cJ MGP_BALBcJ_G0031936
protein coding gene Chr7:26830132-26831457 (+)
C3H/HeJ MGP_C3HHeJ_G0031655
protein coding gene Chr7:27740619-27741944 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032400
protein coding gene Chr7:28217526-28218851 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029452
protein coding gene Chr7:27741594-27742930 (+)
CAST/EiJ MGP_CASTEiJ_G0030990
protein coding gene Chr7:21039858-21041186 (+)
CBA/J MGP_CBAJ_G0031621
protein coding gene Chr7:29498796-29500121 (+)
DBA/2J MGP_DBA2J_G0031773
protein coding gene Chr7:26431701-26433026 (+)
FVB/NJ MGP_FVBNJ_G0031730
protein coding gene Chr7:26507001-26508327 (+)
LP/J MGP_LPJ_G0031853
protein coding gene Chr7:27666226-27667551 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031766
protein coding gene Chr7:28987107-28988432 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032430
protein coding gene Chr7:26843603-26844928 (+)
PWK/PhJ MGP_PWKPhJ_G0030715
protein coding gene Chr7:21449156-21450594 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030548
protein coding gene Chr7:17852769-17854126 (+)
WSB/EiJ MGP_WSBEiJ_G0031099
protein coding gene Chr7:27196240-27197569 (+)



Homology
more
  • Human Ortholog
    SYCN, syncollin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SYCN, syncollin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    INSSA1, SYL
  • Links
    NCBI Gene ID: 342898
    neXtProt AC: NX_Q0VAF6
    UniProt: Q0VAF6

  • Chr Location
    19q13.2; chr19:39202922-39204266 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 12266
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SYCN
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit normal pancreatic morphology, but a reduced rate of pancreatic protein synthesis and intracellular transport of secretory proteins in acinar cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000084174 Ensembl Gene Model | MGI Sequence Detail 1325 C57BL/6J ±  kb
transcript ENSMUST00000119180 Ensembl | MGI Sequence Detail 556 Not Applicable  
polypeptide ENSMUSP00000112770 Ensembl | MGI Sequence Detail 134 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 132
    cDNA 132

    Microarray probesets 3
Other
Accession IDs
less
MGI:1925561
References
more
  • Summaries
    All 27
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 3
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:268425 Li Z, et al., Synemin acts as a regulator of signalling molecules during skeletal muscle hypertrophy. J Cell Sci. 2014 Nov 1;127(Pt 21):4589-601

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory