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Nrn1 Gene Detail
Summary
  • Symbol
    Nrn1
  • Name
    neuritin 1
  • Synonyms
    0710008J23Rik, cpg15
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915654
    NCBI Gene: 68404
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:36725622-36734477 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 14.44 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    28 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915654
protein coding gene Chr13:36725361-36735131 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020463
protein coding gene Chr13:34955714-34967654 (-)
A/J MGP_AJ_G0020417
protein coding gene Chr13:33908437-33917982 (-)
AKR/J MGP_AKRJ_G0020395
protein coding gene Chr13:34760181-34769085 (-)
BALB/cJ MGP_BALBcJ_G0020413
protein coding gene Chr13:33982690-33992936 (-)
C3H/HeJ MGP_C3HHeJ_G0020212
protein coding gene Chr13:34599749-34609169 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020846
protein coding gene Chr13:36116466-36126644 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018433
protein coding gene Chr13:32108270-32117093 (-)
CAST/EiJ MGP_CASTEiJ_G0019727
protein coding gene Chr13:34338630-34351688 (-)
CBA/J MGP_CBAJ_G0020173
protein coding gene Chr13:37679931-37693750 (-)
DBA/2J MGP_DBA2J_G0020295
protein coding gene Chr13:33423012-33432123 (-)
FVB/NJ MGP_FVBNJ_G0020274
protein coding gene Chr13:32961518-32970732 (-)
LP/J MGP_LPJ_G0020370
protein coding gene Chr13:35193983-35203058 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020304
protein coding gene Chr13:37823113-37831910 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020889
protein coding gene Chr13:34328559-34337354 (-)
PWK/PhJ MGP_PWKPhJ_G0019482
protein coding gene Chr13:33539978-33549208 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019313
protein coding gene Chr13:33027259-33036247 (-)
WSB/EiJ MGP_WSBEiJ_G0019789
protein coding gene Chr13:34705303-34714956 (-)



Homology
more
  • Human Ortholog
    NRN1, neuritin 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NRN1, neuritin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    dJ380B8.2, NRN
  • Links
    NCBI Gene ID: 51299
    neXtProt AC: NX_Q9NPD7
    UniProt: Q9NPD7

  • Chr Location
    6p25.1; chr6:5997999-6007605 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9577
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NRN1
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a reduction in body length and body weight, delayed axonal, dendritic, and synaptic development, reduced dendritic spine maintenance leading to gradual spine loss, and impaired associative and spatial learning.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68404 NCBI Gene Model | MGI Sequence Detail 8856 C57BL/6J ±  kb
    transcript NM_153529 RefSeq | MGI Sequence Detail 1622 C57BL/6  
    polypeptide Q8CFV4 UniProt | EBI | MGI Sequence Detail 142 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 30
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 11
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:263280 Monavarfeshani A, et al., LRRTM1 underlies synaptic convergence in visual thalamus. Elife. 2018 Feb 9;7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory