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Nrn1
Gene Detail
Symbol

Name
ID
Nrn1
neuritin 1
MGI:1915654
Synonyms
0710008J23Rik, cpg15
Feature Type
protein coding gene
Genetic Map
Chromosome 13
14.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:36725625-36734477 bp, - strand
From VEGA annotation of GRCm38

  8853 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9577  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NRN1
Protein SuperFamily: neuritin
Gene Tree: Nrn1

Human
homologs
NRN1, neuritin 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 51299
neXtProt AC: NX_Q9NPD7

Human Synonyms: dJ380B8.2, NRN

Human Chr (Location): 6p25.1; chr6:5997999-6007605 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit a reduction in body length and body weight, delayed axonal, dendritic, and synaptic development, reduced dendritic spine maintenance leading to gradual spine loss, and impaired associative and spatial learning.
 
Interactions
Nrn1 interacts with 207 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process axonogenesis, nervous system development
Component AMPA glutamate receptor complex, anchored component of membrane, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (278)    Tissues (30)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 276
RT-PCR 2
cDNA source data(28)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nrn1 ; ZFIN nrn1a, nrn1b    NEW 
Molecular
reagents
All nucleic(29) cDNA(28) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000027720 (Evidence)
Ensembl Gene Model ENSMUSG00000039114 (Evidence)
Entrez Gene 68404 (Evidence)
UniGene 232930
DFCI TC1577672
DoTS DT.97367398, DT.94300425
Consensus CDS Project CCDS26455.1
International Mouse Phenotyping Consortium Status Nrn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027720 VEGA Gene Model | MGI Sequence Detail 8853 C57BL/6J ±  kb
transcript OTTMUST00000068625 VEGA | MGI Sequence Detail 691 Not Applicable 
polypeptide OTTMUSP00000034739 VEGA | MGI Sequence Detail 158 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(28 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026144 Neuritin family
Protein Ontology PR:000011434 neuritin
References
(Earliest) J:39324 Naeve GS, et al., Neuritin: a gene induced by neural activity and neurotrophins that promotes neuritogenesis. Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2648-53
(Latest) J:209345 Picard N, et al., Aberrant development and plasticity of excitatory visual cortical networks in the absence of cpg15. J Neurosci. 2014 Mar 5;34(10):3517-22
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory