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Nrn1 Gene Detail
Summary
  • Symbol
    Nrn1
  • Name
    neuritin 1
  • Synonyms
    0710008J23Rik, cpg15
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915654
    NCBI Gene: 68404
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr13:36725625-36734477 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8853 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 14.44 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    NRN1, neuritin 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NRN1, neuritin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    dJ380B8.2, NRN
  • Links
    NCBI Gene ID: 51299
    neXtProt AC: NX_Q9NPD7
    UniProt: Q9NPD7

  • Chr Location
    6p25.1; chr6:5997999-6007605 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9577
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NRN1
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 1 allele in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a reduction in body length and body weight, delayed axonal, dendritic, and synaptic development, reduced dendritic spine maintenance leading to gradual spine loss, and impaired associative and spatial learning.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000027720 VEGA Gene Model | MGI Sequence Detail 8853 C57BL/6J ±  kb
    transcript OTTMUST00000068625 VEGA | MGI Sequence Detail 691 Not Applicable  
    polypeptide OTTMUSP00000034739 VEGA | MGI Sequence Detail 158 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      28 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 30
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 11
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:263280 Monavarfeshani A, et al., LRRTM1 underlies synaptic convergence in visual thalamus. Elife. 2018 Feb 9;7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory