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G6pc3 Gene Detail
Summary
  • Symbol
    G6pc3
  • Name
    glucose 6 phosphatase, catalytic, 3
  • Synonyms
    0710001K01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915651
    NCBI Gene: 68401
  • Gene Overview
    MyGene.info: G6PC3
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:102189699-102194081 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 65.79 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    28 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915651
protein coding gene Chr11:102189620-102194081 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019225
protein coding gene Chr11:105142303-105146754 (+)
A/J MGP_AJ_G0019193
protein coding gene Chr11:100703456-100707917 (+)
AKR/J MGP_AKRJ_G0019162
protein coding gene Chr11:103823095-103827546 (+)
BALB/cJ MGP_BALBcJ_G0019167
protein coding gene Chr11:101191593-101196044 (+)
C3H/HeJ MGP_C3HHeJ_G0018976
protein coding gene Chr11:104024645-104029096 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019616
protein coding gene Chr11:108415819-108422673 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017242
protein coding gene Chr11:98133226-98137737 (+)
CAST/EiJ MGP_CASTEiJ_G0018530
protein coding gene Chr11:104999326-105003802 (+)
CBA/J MGP_CBAJ_G0018945
protein coding gene Chr11:112890159-112894583 (+)
DBA/2J MGP_DBA2J_G0019057
protein coding gene Chr11:100227694-100232146 (+)
FVB/NJ MGP_FVBNJ_G0019047
protein coding gene Chr11:99755900-99760354 (+)
LP/J MGP_LPJ_G0019126
protein coding gene Chr11:105664066-105668547 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019078
protein coding gene Chr11:112413466-112417966 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019654
protein coding gene Chr11:104182826-104187274 (+)
PWK/PhJ MGP_PWKPhJ_G0018293
protein coding gene Chr11:101289754-101294292 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018085
protein coding gene Chr11:103939626-103944849 (+)
WSB/EiJ MGP_WSBEiJ_G0018579
protein coding gene Chr11:104175621-104180071 (+)



Homology
more
  • Human Ortholog
    G6PC3, glucose-6-phosphatase catalytic subunit 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    G6PC3, glucose-6-phosphatase catalytic subunit 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SCN4, UGRP
  • Links
    NCBI Gene ID: 92579
    neXtProt AC: NX_Q9BUM1
    UniProt: Q9BUM1

  • Chr Location
    17q21.31; chr17:44070700-44076344 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human G6PC3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in females, but not males, that are growth retarded and weight less and exhibit elevated plasma glucagon levels but lowered plasma cholesterols after fasting.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68401 NCBI Gene Model | MGI Sequence Detail 4383 C57BL/6J ±  kb
    transcript NM_175935 RefSeq | MGI Sequence Detail 1612 FVB/N  
    polypeptide Q6NSQ9 UniProt | EBI | MGI Sequence Detail 346 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 60
      Genomic 1
      cDNA 59

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2144389, MGI:2144442, MGI:2144461, MGI:2144559
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
    • Latest
      J:236179 Bowman CE, et al., Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series. Mol Cell Biol. 2016 Aug 1;36(15):2089-104

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory