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G6pc3
Gene Detail
Symbol

Name
ID
G6pc3
glucose 6 phosphatase, catalytic, 3
MGI:1915651
Synonyms
0710001K01Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 11
65.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:102189620-102194081 bp, + strand
From VEGA annotation of GRCm38

  4462 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:16304  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: G6PC3
Protein SuperFamily: glucose-6-phosphatase
Gene Tree: G6pc3

Human
homologs
G6PC3, glucose 6 phosphatase, catalytic, 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 92579
neXtProt AC: NX_Q9BUM1

Human Synonyms: SCN4, UGRP

Human Chr (Location): 17q21.31; chr17:44070730-44076344 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human G6PC3

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Genomic Mutations involving G6pc3 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in females, but not males, that are growth retarded and weight less and exhibit elevated plasma glucagon levels but lowered plasma cholesterols after fasting.
 
Interactions
G6pc3 interacts with 40 markers (Mir27a, Mir122, Mir137, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process dephosphorylation, gluconeogenesis, ...
Component endoplasmic reticulum, integral component of endoplasmic reticulum membrane, ...
Function catalytic activity, glucose-6-phosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (135)    Tissues (97)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 135
cDNA source data(58)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(59) Genomic(1) cDNA(58)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000002495 (Evidence)
Ensembl Gene Model ENSMUSG00000034793 (Evidence)
Entrez Gene 68401 (Evidence)
UniGene 22385
DFCI TC1576450
DoTS DT.531112, DT.101304724
NIA Mouse Gene Index U013384
EC 3.1.3.9
Consensus CDS Project CCDS25491.1
International Mouse Phenotyping Consortium Status G6pc3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002495 VEGA Gene Model | MGI Sequence Detail 4462 C57BL/6J ±  kb
transcript OTTMUST00000004884 VEGA | MGI Sequence Detail 1404 Not Applicable 
polypeptide OTTMUSP00000002347 VEGA | MGI Sequence Detail 346 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(28 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016275 Glucose-6-phosphatase
InterPro IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase
Protein Ontology PR:000007748 glucose-6-phosphatase 3
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:183817 Jun HS, et al., Glucose-6-phosphatase-beta, implicated in a congenital neutropenia syndrome, is essential for macrophage energy homeostasis and functionality. Blood. 2012 Apr 26;119(17):4047-55
All references(41)
Other
accession IDs
MGI:2144389, MGI:2144442, MGI:2144461, MGI:2144559

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory