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Ndufs3
Gene Detail
Symbol

Name
ID
Ndufs3
NADH dehydrogenase (ubiquinone) Fe-S protein 3
MGI:1915599
Synonyms
0610010M09Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 2
50.44 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:90894634-90904827 bp, - strand
From VEGA annotation of GRCm38

  10194 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3346  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NDUFS3
Protein SuperFamily: NADH:quinone oxidoreductase (complex I), subunit 30kD/NdhJ/NuoC
Gene Tree: Ndufs3

Human
homologs
NDUFS3, NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4722
neXtProt AC: NX_O75489

Human Synonyms: CI-30

Human Chr (Location): 11p11.11; chr11:47579010-47584563 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human NDUFS3

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(5) Targeted(5)
Genomic Mutations involving Ndufs3 (2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Ndufs3 interacts with 24 markers (Mir125a, Mir125b-1, Mir125b-2, ...)
Expression
Literature Summary: (3 records)
Data Summary: Results (160)    Tissues (101)    Images (36)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 160
cDNA source data(64)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ndufs3    NEW 
Molecular
reagents
All nucleic(65) cDNA(64) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000014317 (Evidence)
Ensembl Gene Model ENSMUSG00000005510 (Evidence)
Entrez Gene 68349 (Evidence)
UniGene 30113
DFCI TC1572169
NIA Mouse Gene Index U023009, U066676, U102626
EC 1.6.5.3, 1.6.99.3
Consensus CDS Project CCDS16418.1
International Mouse Phenotyping Consortium Status Ndufs3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014317 VEGA Gene Model | MGI Sequence Detail 10194 C57BL/6J ±  kb
transcript OTTMUST00000033776 VEGA | MGI Sequence Detail 1046 Not Applicable 
polypeptide OTTMUSP00000015131 VEGA | MGI Sequence Detail 263 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(31 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010218 NADH dehydrogenase, subunit C
InterPro IPR001268 NADH:ubiquinone oxidoreductase, 30kDa subunit
InterPro IPR020396 NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site
Protein Ontology PR:000011098 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:206222 Peralta S, et al., Partial complex I deficiency due to the CNS conditional ablation of Ndufa5 results in a mild chronic encephalopathy but no increase in oxidative damage. Hum Mol Genet. 2014 Mar 15;23(6):1399-412
All references(43)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory