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Ndufs3 Gene Detail
Summary
  • Symbol
    Ndufs3
  • Name
    NADH:ubiquinone oxidoreductase core subunit S3
  • Synonyms
    0610010M09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915599
    NCBI Gene: 68349
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:90724971-90735065 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 50.44 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    242 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915599
 protein coding gene Chr2:90724971-90735171 (-)
129S1/SvImJ ENSMUSG00200051454
 protein coding gene Chr2:87640368-87650935 (-)
A/J ENSMUSG00195049066
 protein coding gene Chr2:87765756-87776333 (-)
AKR/J ENSMUSG00220047230
 protein coding gene Chr2:87570057-87580624 (-)
BALB/cJ ENSMUSG00180054788
 protein coding gene Chr2:87665999-87676557 (-)
C3H/HeJ ENSMUSG00175053983
 protein coding gene Chr2:87936053-87946619 (-)
C57BL/6NJ ENSMUSG00215053594
 protein coding gene Chr2:87767466-87778033 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023947
 protein coding gene Chr2:85019785-85029539 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210039286
 protein coding gene Chr2:87947234-87957801 (-)
DBA/2J ENSMUSG00185056005
 protein coding gene Chr2:87662438-87673014 (-)
FVB/NJ ENSMUSG00205051035
 protein coding gene Chr2:86960283-86970851 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230036661
 protein coding gene Chr2:89413134-89423711 (-)
NOD/ShiLtJ ENSMUSG00190046594
 protein coding gene Chr2:87741006-87751660 (-)
NZO/HlLtJ ENSMUSG00225049325
 protein coding gene Chr2:97334705-97345282 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    NDUFS3, NADH:ubiquinone oxidoreductase core subunit S3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NDUFS3, NADH:ubiquinone oxidoreductase core subunit S3
  • Synonyms
    CI-30, MC1DN8
  • Links
    NCBI Gene ID: 4722
    UniProt: O75489

  • Chr Location
    11p11.2; chr11:47565336-47584565 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NDUFS3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    757
  • Tissues
    101
  • cDNA Data
    65
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68349 NCBI Gene Model | MGI Sequence Detail 10095 C57BL/6J ±  kb
    transcript NM_026688 RefSeq | MGI Sequence Detail 949 C57BL/6  
    polypeptide Q9DCT2 UniProt | EBI | MGI Sequence Detail 263 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 66
      cDNA 65
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 3
      Gene Ontology 21
      Phenotypes 19
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:368251 Walker BR, et al., Restoration of defective oxidative phosphorylation to a subset of neurons prevents mitochondrial encephalopathy. EMBO Mol Med. 2024 Sep;16(9):2210-2232
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory