About   Help   FAQ
Sirt5 Gene Detail
Summary
  • Symbol
    Sirt5
  • Name
    sirtuin 5
  • Synonyms
    0610012J09Rik, 1500032M05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915596
    NCBI Gene: 68346
  • Gene Overview
    MyGene.info: SIRT5
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr13:43365496-43395203 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      29708 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 21.60 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SIRT5, sirtuin 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SIRT5, sirtuin 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SIR2L5
  • Links
    NCBI Gene ID: 23408
    neXtProt AC: NX_Q9NXA8
    UniProt: Q9NXA8

  • Chr Location
    6p23; chr6:13574222-13615158 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable, fertile and grossly healthy and do not exhibit globally increased mitochondrial protein acetylation levels relative to wild-type controls.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000054021 Ensembl Gene Model | MGI Sequence Detail 29708 C57BL/6J ±  kb
    transcript ENSMUST00000221515 Ensembl | MGI Sequence Detail 1793 Not Applicable  
    polypeptide ENSMUSP00000152526 Ensembl | MGI Sequence Detail 350 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      173 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 20
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1917010, MGI:2145383
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 4
      Gene Ontology 13
      Phenotypes 23
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:261391 Chen XF, et al., SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer. EMBO Rep. 2018 May;19(5)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory