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Crip2 Gene Detail
Summary
  • Symbol
    Crip2
  • Name
    cysteine rich protein 2
  • Synonyms
    0610010I23Rik, Crp, CRP4, ESP1, Hlp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915587
    NCBI Gene: 68337
  • Gene Overview
    MyGene.info: CRIP2
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:113140236-113145506 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 61.57 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915587
protein coding gene Chr12:113140236-113145506 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020172
protein coding gene Chr12:115636623-115641557 (+)
A/J MGP_AJ_G0020128
protein coding gene Chr12:111158458-111163713 (+)
AKR/J MGP_AKRJ_G0020103
protein coding gene Chr12:114389986-114394920 (+)
BALB/cJ MGP_BALBcJ_G0020113
protein coding gene Chr12:111624279-111629213 (+)
C3H/HeJ MGP_C3HHeJ_G0019915
protein coding gene Chr12:114911615-114916870 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020558
protein coding gene Chr12:119182003-119186937 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018172
protein coding gene Chr12:107592280-107597630 (+)
CAST/EiJ MGP_CASTEiJ_G0019455
protein coding gene Chr12:109755977-109762078 (+)
CBA/J MGP_CBAJ_G0019882
protein coding gene Chr12:123749679-123754934 (+)
DBA/2J MGP_DBA2J_G0019999
protein coding gene Chr12:110659893-110664827 (+)
FVB/NJ MGP_FVBNJ_G0019984
protein coding gene Chr12:109503213-109508468 (+)
LP/J MGP_LPJ_G0020073
protein coding gene Chr12:115456957-115461891 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020022
protein coding gene Chr12:126836568-126841502 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020587
protein coding gene Chr12:113906374-113911629 (+)
PWK/PhJ MGP_PWKPhJ_G0019217
protein coding gene Chr12:105321277-105326759 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019021
protein coding gene Chr12:108086383-108091642 (+)
WSB/EiJ MGP_WSBEiJ_G0019515
protein coding gene Chr12:114820616-114825871 (+)



Homology
more
  • Human Ortholog
    CRIP2, cysteine rich protein 2
  • Vertebrate Orthologs
    6
  • Human Ortholog
    CRIP2, cysteine rich protein 2
    Orthology source: HGNC
  • Synonyms
    CRIP, CRP2, ESP1
  • Links
    NCBI Gene ID: 1397
    neXtProt AC: NX_P52943
    UniProt: P52943

  • Chr Location
    14q32.33; chr14:105472938-105480170 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display abnormal inflammatory pain responses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 68337 NCBI Gene Model | MGI Sequence Detail 5271 C57BL/6J ±  kb
transcript NM_024223 RefSeq | MGI Sequence Detail 1454 C57BL/6  
polypeptide Q9DCT8 UniProt | EBI | MGI Sequence Detail 208 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 10
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2145057, MGI:2145082
References
more
  • Summaries
    All 45
    Developmental Gene Expression 11
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:31705 Karim MA, et al., Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3. Genomics. 1996 Jan 15;31(2):167-76
  • Latest
    J:225747 Jayewickreme CD, et al., Control of stomach smooth muscle development and intestinal rotation by transcription factor BARX1. Dev Biol. 2015 Sep 1;405(1):21-32

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory