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Sdhaf1 Gene Detail
Summary
  • Symbol
    Sdhaf1
  • Name
    succinate dehydrogenase complex assembly factor 1
  • Synonyms
    0610010E21Rik, Lyrm8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915582
    NCBI Gene: 68332
Location & Maps
more
  • Sequence Map
    Chr7:30321406-30323895 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2490 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 17.39 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SDHAF1, succinate dehydrogenase complex assembly factor 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SDHAF1, succinate dehydrogenase complex assembly factor 1
    Orthology source: HomoloGene
  • Synonyms
    LYRM8
  • Links
    NCBI Gene ID: 644096
    neXtProt AC: NX_A6NFY7

  • Chr Location
    19q13.12; chr19:35995188-35996318 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human SDHAF1 associations

Human Disease Mouse Models
       Mitochondrial Complex II Deficiency   OMIM: 252011
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
  • All Mutations and Alleles
    3
  • Gene trapped
    1
  • Targeted
    2
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022883 VEGA Gene Model | MGI Sequence Detail 2490 C57BL/6J ±  kb
transcript OTTMUST00000055041 VEGA | MGI Sequence Detail 2490 Not Applicable  
polypeptide OTTMUSP00000026298 VEGA | MGI Sequence Detail 118 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    85 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000030806 succinate dehydrogenase assembly factor 1, mitochondrial
  • InterPro Domains
    IPR008011 Complex 1 LYR protein
Molecular
Reagents
less
  • All nucleic 36
    cDNA 36

    Microarray probesets 3
Other
Accession IDs
less
MGI:2141957, MGI:2142235
References
more
  • Summaries
    All 26
    Gene Ontology 2
    Phenotypes 4
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:151002 Pagliarini DJ, et al., A mitochondrial protein compendium elucidates complex I disease biology. Cell. 2008 Jul 11;134(1):112-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory