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Cep57 Gene Detail
Summary
  • Symbol
    Cep57
  • Name
    centrosomal protein 57
  • Synonyms
    3110002L15Rik, 4921510P06Rik, 4931428M20Rik, mKIAA0092, Tsp57
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915551
    NCBI Gene: 74360
  • Gene Overview
    MyGene.info: CEP57
Location & Maps
more
  • Sequence Map
    Chr9:13807792-13827107 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19316 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CEP57, centrosomal protein 57
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CEP57, centrosomal protein 57
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MVA2, PIG8, TSP57
  • Links
    NCBI Gene ID: 9702
    neXtProt AC: NX_Q86XR8

  • Chr Location
    11q21; chr11:95790461-95832693 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8790
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: CEP57
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human CEP57 associations

Human Disease Mouse Models
       Mosaic Variegated Aneuploidy Syndrome 2; MVA2   OMIM: 614114
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033418 VEGA Gene Model | MGI Sequence Detail 19316 C57BL/6J ±  kb
transcript OTTMUST00000083911 VEGA | MGI Sequence Detail 2523 Not Applicable  
polypeptide OTTMUSP00000045144 VEGA | MGI Sequence Detail 500 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    86 from dbSNP Build 142
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000005352 centrosomal protein of 57 kDa
  • InterPro Domains
    IPR010597 Centrosomal protein 57kDa
    IPR025913 Cep57 centrosome localisation domain
    IPR024957 Cep57 centrosome microtubule-binding domain
Molecular
Reagents
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  • All nucleic 12
    cDNA 12

    Microarray probesets 9
Other
Accession IDs
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MGI:1914656, MGI:1921610, MGI:2143073
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:198579 He R, et al., Cep57 protein is required for cytokinesis by facilitating central spindle microtubule organization. J Biol Chem. 2013 May 17;288(20):14384-90

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory