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Cep57
Gene Detail
Symbol

Name
ID
Cep57
centrosomal protein 57
MGI:1915551
Synonyms
3110002L15Rik, 4921510P06Rik, 4931428M20Rik, mKIAA0092, Tsp57
Feature Type
protein coding gene
Genetic Map
Chromosome 9
3.49 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:13807792-13827107 bp, - strand
From VEGA annotation of GRCm38

  19316 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8790  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CEP57
Gene Tree: Cep57

Human
homologs
CEP57, centrosomal protein 57kDa
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9702
neXtProt AC: NX_Q86XR8

Human Synonyms: MVA2, PIG8, TSP57

Human Chr (Location): 11q21; chr11:95790461-95832693 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CEP57

Mutations,
alleles, and
phenotypes
All mutations/alleles(33) : Gene trapped(31) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Cep57 interacts with 244 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process fibroblast growth factor receptor signaling pathway, microtubule anchoring, ...
Component cell, centrosome, ...
Function fibroblast growth factor binding, gamma-tubulin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (31)    Tissues (2)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 31
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cep57    NEW 
Molecular
reagents
All nucleic(12) cDNA(12)
Microarray probesets(9)
Other database
links
VEGA Gene Model OTTMUSG00000033418 (Evidence)
Ensembl Gene Model ENSMUSG00000031922 (Evidence)
Entrez Gene 74360 (Evidence)
DFCI TC1622989, TC1575814, TC1638584, TC1659210
DoTS DT.101394254, DT.101394251, DT.101148222, DT.101736712, DT.40182418, DT.91360953, DT.91447857, DT.94399023
NIA Mouse Gene Index U030477
Consensus CDS Project CCDS52724.1
International Mouse Phenotyping Consortium Status Cep57
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033418 VEGA Gene Model | MGI Sequence Detail 19316 C57BL/6J ±  kb
transcript OTTMUST00000083911 VEGA | MGI Sequence Detail 2523 Not Applicable 
polypeptide OTTMUSP00000045144 VEGA | MGI Sequence Detail 500 Not Applicable 

For the selected sequences
All sequences(100) RefSeq(9) UniProt(8)
Polymorphisms
SNPs within 2kb(83 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010597 Centrosomal protein 57kDa
InterPro IPR025913 Cep57 centrosome localisation domain
InterPro IPR024957 Cep57 centrosome microtubule-binding domain
Protein Ontology PR:000005352 centrosomal protein of 57 kDa
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:198579 He R, et al., Cep57 protein is required for cytokinesis by facilitating central spindle microtubule organization. J Biol Chem. 2013 May 17;288(20):14384-90
All references(38)
Other
accession IDs
MGI:1914656, MGI:1921610, MGI:2143073

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory